PLOD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLOD3_MOUSE
• UniProt AC: Q9R0E1
• Protein Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
• Gene Name: Plod3
• Organism: Mus musculus (Mouse).
• Sequence Length: 741
• Subcellular Localization: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
• Protein Description: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links..
• Protein Sequence: MAAAGPEPRLLLLLLLLLPPLPPVTSASDRPRGANAVNPDKLLVITVATAETEGYRRFLQSAEFFNYTVRTLGLGQEWRGGDVARTVGGGQKVRWLKKEMEKYADQKDMIIMFVDSYDVILASSPTELLKKFVQSGSHLLFSAESFCWPEWGLAEQYPEVGMGKRFLNSGGFIGFAPTIHQIVRQWNYKDDDDDQLFYTQLYLDPGLREKLKLSLDHKSRIFQNLNGALDEVILKFDQNRVRIRNVAYDTLPVVVHGNGPTKLQLNYLGNYVPNGWTPQGGCGFCNQTLRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDYPPDRISLFLHNSEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSAGEARDMAMDSCRQNPECEFYFSLDADAVLTNPETLRVLIEQNRKVIAPMLSRHGKLWSNFWGALSPNEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGETLRTELPQKEVFSSSDTDPDMAFCKSVRDKGIFLHLSNQHEFGRLLATSRYDTDHLHPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPCPDVYWFPLLTEQMCDELVEEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTEYLFPGYHTKTRAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGVDYEGGGCRFLRYDCRISSPRKGWALLHPGRLTHYHEGLPTTRGTRYIMVSFVDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	N-linked_Glycosylation	LQSAEFFNYTVRTLG HHHHHHCCEEEEECC	36.57	19349973
178	Phosphorylation	GFIGFAPTIHQIVRQ CCCCCCHHHHHHHHH	27.88	-
286	N-linked_Glycosylation	QGGCGFCNQTLRTLP CCCCCCCCCHHHCCC	35.29	-
551	N-linked_Glycosylation	REQYIHENYSRALDG HHHHHHHHHHCCCCC	26.39	-
648	Acetylation	LFPGYHTKTRAVMNF CCCCCCCCHHEEEEE	23.77	23236377
705	Phosphorylation	RYDCRISSPRKGWAL EEECEECCCCCCEEE	26.76	-
708	Acetylation	CRISSPRKGWALLHP CEECCCCCCEEEECC	63.29	23806337
708	Succinylation	CRISSPRKGWALLHP CEECCCCCCEEEECC	63.29	23806337
727	Phosphorylation	HYHEGLPTTRGTRYI EECCCCCCCCCCEEE	33.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLOD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLOD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLOD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLOD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66, AND MASS SPECTROMETRY.
PubMed: 19349973