CROCC_MOUSE - dbPTM
CROCC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CROCC_MOUSE
UniProt AC Q8CJ40
Protein Name Rootletin
Gene Name Crocc {ECO:0000312|MGI:MGI:3529431}
Organism Mus musculus (Mouse).
Sequence Length 2009
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . In ciliated cells, associated with ciliary rootlets. In
Protein Description Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. [PubMed: 12427867 Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (By similarity Contributes to centrosome cohesion before mitosis (By similarity]
Protein Sequence MSLGLAGSLQAQLALEIVIQSLENCVLGPNQEKSLSVQNRVQDFQGASLLVCAREVIASNLSRPETPAPLQVPEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVNERLEQAVRLETGELEAQEPRGLVRQSVELRRQLQEEQSSYRRKLQAYQEGQQRQAQLVQRLQAKILQYKKQCSELEKQLMDRSTELEQQRLRDTEHSQDLDSALLRLEEEQQRSASLAQVNAMLREQLDQANLANQALSEDIRKVTSDWTRSCKELEQREAVWRREEESFNTYFSSEHSRLLRLWRQVMGLRRQASEVKMGTERDLLQLGGELVRTSRAVQELGLGLSASLHRAESKAEAALEKQKLLQAQLEEQLQAKLLREKDLAQLQVQSDLDKADLSARVTELALSVEHLQNQNSEKDQVNRTLSDKLEALESLRLQEQTTLDTEDGEGLQQTLRDLAQAALSDTESGVQLSSSERTADTSDGSLRGFSGQRTPTPPRHSPGRGRSPRRGLSPACSDSSTLTLIHSALHKRQLQVQDMRGRYEASQELLGSVRKQLSDSEGERRGLEEQLQRLRDQTAASAQAQEDAQREAQRLRSANELLSREKGNLTHSLQVTQQQAKELRQELEKLQAAQEELKRQHNQLEDAQEDSVQEGARARRELERSHRQLEQLEVKRSGLTKELVEVREALSCAILQRDVLQTEKAEVAEALTKAEAGRAQLELSLTKLRAEEASLRDSLSKMSALNESLAQDKLELNRLIAQLEEEKVALLGRQQQAEHATTMAVEKQELLEQLRLEQEVERQGLQGSLCVAEQAREALEQQILVLRSERSHLQEQLAQLSRQLSGRDQELEQALRESQRQVEALERAAREKEAMAKERAGLAVKLAAAEREGRTLSEEAIRLRLEKEALESSLFDVQRQLAQLEARREQLEADSQALLLAKETLTGELAGLRQQVTSTEEKAALDKELMTQKLVQAEREAQASLREQRAAHEEDLQRLQHEKEAAWRELQAERAQLQGQLQQEREELLARMEAEKEELSKEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAAISLEMERQKRDAQSRQEQDRNTLNALTSELRDLRAQLEEATAAHAQTVKELEERTGNLGRQREACMREAEELRTQLRVLEDTRDGLRRELLEAQRKGRDSQDSSEAHRQEASELRRSLSEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARVSVAKEAGELRASLQEVERSRLEARRELQELRRQMKTLDSDNGRLGRELADLQGRLALGERTEKESRREALGLRQRLLKGESSLEALKQELQGSQRKLQEQEAEFRARERGLLGSLEEARGAEKRLLDSARSLELRLEAVRAETSELGLRLSAAEGRAQGLEVELARVEAQRRVAEAQLGGLRSALRRGLGLGRVSSSPAREAPAGGSGDGLSSPSPLEYSPRSQPPSPGLIASPAPPDLDPEAVRDALRDFLQELRSAQRERDELKVQTSTLSQQLVEMEAERDHAASRAKQLQKAVAESEEAWRSADRRLSGAQAELALQEESVRRSKRECRATLDQMAVLERSLQATESELRASQEKVSKMKATEAKLESDKRRLKEVLDASESRSIKLELQRRALEGELQRSRLGLGDREAHAQALQDRVDSLQRQVADSEVKAGTLQLTVERLSGALAKVEESEGNLRSKVQSLTDALTQSSASLSSTQDKNLHLQKALSTCEHDRQVLQERLDAARQALSEARRQSSSLGEQVQTLRGELASLELQRGDAEGQLQQLQQALRQRQEGEAMALRSVQKLQEERRLLQERLGSLQRALAQLEAEKRDLERSALQFDKDRVALRKTLDKVEREKLRSHEDTLRLNAERGRLDRTLTGAELDLAEAQQQIQHLEAQVDVALEGNHNPVQPEAGEQQLELQQEVERLRSAQVQTERTLEARERAHRQRVSGLEEQVSTLKAQLHQELRRSSASVSLPPGTPEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
128PhosphorylationEQAVRLETGELEAQE
HHHHHHHCCCCCCCC		40.31-
164PhosphorylationYRRKLQAYQEGQQRQ
HHHHHHHHHHHHHHH		8.3029899451
181AcetylationLVQRLQAKILQYKKQ
HHHHHHHHHHHHHHH		30.877629285
186AcetylationQAKILQYKKQCSELE
HHHHHHHHHHHHHHH		24.337629295
319PhosphorylationASEVKMGTERDLLQL
HHCCCCCCHHHHHHH		25.0928285833
407PhosphorylationRVTELALSVEHLQNQ
HHHHHHHHHHHHHCC		21.6122817900
424PhosphorylationEKDQVNRTLSDKLEA
CHHHHHHHHHHHHHH		25.96-
426PhosphorylationDQVNRTLSDKLEALE
HHHHHHHHHHHHHHH		31.89-
428UbiquitinationVNRTLSDKLEALESL
HHHHHHHHHHHHHHH		44.8722790023
454PhosphorylationDGEGLQQTLRDLAQA
CCHHHHHHHHHHHHH		15.7022807455
464PhosphorylationDLAQAALSDTESGVQ
HHHHHHHCCCCCCEE		37.4526525534
466PhosphorylationAQAALSDTESGVQLS
HHHHHCCCCCCEECC		28.7719060867
468PhosphorylationAALSDTESGVQLSSS
HHHCCCCCCEECCCC		46.4825293948
473PhosphorylationTESGVQLSSSERTAD
CCCCEECCCCCEEEC		18.0930635358
474PhosphorylationESGVQLSSSERTADT
CCCEECCCCCEEECC		44.8230635358
475PhosphorylationSGVQLSSSERTADTS
CCEECCCCCEEECCC		27.9330635358
485PhosphorylationTADTSDGSLRGFSGQ
EECCCCCCCCCCCCC		21.6325521595
490PhosphorylationDGSLRGFSGQRTPTP
CCCCCCCCCCCCCCC		36.5223684622
494PhosphorylationRGFSGQRTPTPPRHS
CCCCCCCCCCCCCCC		24.5122817900
496PhosphorylationFSGQRTPTPPRHSPG
CCCCCCCCCCCCCCC		45.3625521595
501PhosphorylationTPTPPRHSPGRGRSP
CCCCCCCCCCCCCCC		30.2625521595
507PhosphorylationHSPGRGRSPRRGLSP
CCCCCCCCCCCCCCC		26.11-
513PhosphorylationRSPRRGLSPACSDSS
CCCCCCCCCCCCCHH		17.1825521595
517PhosphorylationRGLSPACSDSSTLTL
CCCCCCCCCHHHHHH		42.5126745281
738PhosphorylationEEASLRDSLSKMSAL
HHHHHHHHHHHHHHH		28.2727149854
858PhosphorylationLEQALRESQRQVEAL
HHHHHHHHHHHHHHH		24.9929514104
958PhosphorylationGLRQQVTSTEEKAAL
HHHHHCCCHHHHHHH		34.6621454597
971PhosphorylationALDKELMTQKLVQAE
HHCHHHHHHHHHHHH		34.8721454597
1119MethylationNALTSELRDLRAQLE
HHHHHHHHHHHHHHH		36.54-
1200PhosphorylationEAHRQEASELRRSLS
HHHHHHHHHHHHHHH		36.09-
1205PhosphorylationEASELRRSLSEGAKE
HHHHHHHHHHHHHHH		29.79-
1207PhosphorylationSELRRSLSEGAKERE
HHHHHHHHHHHHHHH		34.9229899451
1223PhosphorylationLRRSNEELRSAVKKA
HHHCHHHHHHHHHHH		4.2324719451
1399PhosphorylationLEAVRAETSELGLRL
HHHHHHHHHHHHHHH		26.9022817900
1400PhosphorylationEAVRAETSELGLRLS
HHHHHHHHHHHHHHH		23.4822817900
1407PhosphorylationSELGLRLSAAEGRAQ
HHHHHHHHHHHHHHC		20.9922817900
1439PhosphorylationAQLGGLRSALRRGLG
HHHHHHHHHHHHCCC		36.3822942356
1453PhosphorylationGLGRVSSSPAREAPA
CCCCCCCCCCCCCCC		18.3129899451
1463PhosphorylationREAPAGGSGDGLSSP
CCCCCCCCCCCCCCC		32.5621082442
1468PhosphorylationGGSGDGLSSPSPLEY
CCCCCCCCCCCCCCC		45.8125521595
1469PhosphorylationGSGDGLSSPSPLEYS
CCCCCCCCCCCCCCC		34.1425521595
1471PhosphorylationGDGLSSPSPLEYSPR
CCCCCCCCCCCCCCC		44.0319060867
1475PhosphorylationSSPSPLEYSPRSQPP
CCCCCCCCCCCCCCC		31.4925521595
1476PhosphorylationSPSPLEYSPRSQPPS
CCCCCCCCCCCCCCC		12.4025521595
1479PhosphorylationPLEYSPRSQPPSPGL
CCCCCCCCCCCCCCC		50.8821082442
1483PhosphorylationSPRSQPPSPGLIASP
CCCCCCCCCCCCCCC		37.9825521595
1489PhosphorylationPSPGLIASPAPPDLD
CCCCCCCCCCCCCCC		18.0121082442
1568PhosphorylationRSADRRLSGAQAELA
HHHHHHHHHHHHHHH		30.2128833060
1661PhosphorylationLEGELQRSRLGLGDR
HHHHHHHHHCCCCCH		20.9221454597
1860PhosphorylationEKRDLERSALQFDKD
HHHHHHHHHHHCCHH		24.7725159016
1996PhosphorylationLHQELRRSSASVSLP
HHHHHHHHHCCCCCC		24.6729899451
1997PhosphorylationHQELRRSSASVSLPP
HHHHHHHHCCCCCCC		23.8121183079
1999PhosphorylationELRRSSASVSLPPGT
HHHHHHCCCCCCCCC		17.7429899451
2006PhosphorylationSVSLPPGTPEK----
CCCCCCCCCCC----		33.7627841257
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CROCC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CROCC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CROCC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KLC3_MOUSEKlc3physical
16018997
APBP2_MOUSEAppbp2physical
16018997
RB11A_HUMANRAB11Aphysical
26496610
CLAP2_HUMANCLASP2physical
26496610
UBE2O_HUMANUBE2Ophysical
26496610
CMBL_HUMANCMBLphysical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CROCC_MOUSE

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Related Literatures of Post-Translational Modification

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