RPAB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPAB3_MOUSE
• UniProt AC: Q923G2
• Protein Name: DNA-directed RNA polymerases I, II, and III subunit RPABC3
• Gene Name: Polr2h
• Organism: Mus musculus (Mouse).
• Sequence Length: 150
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity)..
• Protein Sequence: MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGILFEDI ------CCCCEEEEC	17.46	-
20	Acetylation	KDIDPEGKKFDRVSR CCCCCCCCCCCCEEE	48.91	30987101
75	Phosphorylation	GTLDDGEYNPTDDRP CCCCCCCCCCCCCCC	31.78	24224561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPAB3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPAB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPAB3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RPAB3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.