NDUA8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUA8_MOUSE
• UniProt AC: Q9DCJ5
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
• Gene Name: Ndufa8
• Organism: Mus musculus (Mouse).
• Sequence Length: 172
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein . Mitochondrion intermembrane space . Mitochondrion .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MPGIVELPTLEELKVEEVKVSSAVLKAAAHHYGAQCDKTNKEFMLCRWEEKDPRRCLKEGKLVNGCALNFFRQIKSHCAEPFTEYWTCLDYSNMQLFRHCRQQQAKFDQCVLDKLGWVRPDLGQLSKVTKVKTDRPLPENPYHSRARPEPNPVIEGDLKPAKHGTRFFFWTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Succinylation	LPTLEELKVEEVKVS CCCHHHEEEEEEECC	51.37	23954790
38	Acetylation	HYGAQCDKTNKEFML HCCCCCCCCCCEEEE	62.72	23864654
61	Acetylation	RRCLKEGKLVNGCAL HHHHHHCCEECCHHH	50.80	23201123
66	S-nitrosylation	EGKLVNGCALNFFRQ HCCEECCHHHHHHHH	3.08	22588120
66	S-palmitoylation	EGKLVNGCALNFFRQ HCCEECCHHHHHHHH	3.08	28526873
106	Ubiquitination	HCRQQQAKFDQCVLD HHHHHHHHHHHHHHH	45.17	-
106	Acetylation	HCRQQQAKFDQCVLD HHHHHHHHHHHHHHH	45.17	23864654
106	Succinylation	HCRQQQAKFDQCVLD HHHHHHHHHHHHHHH	45.17	26388266
132	Malonylation	LSKVTKVKTDRPLPE HCCCEECCCCCCCCC	46.38	26320211
132	Succinylation	LSKVTKVKTDRPLPE HCCCEECCCCCCCCC	46.38	23954790
142	Phosphorylation	RPLPENPYHSRARPE CCCCCCCCCCCCCCC	24.82	22817900
144	Phosphorylation	LPENPYHSRARPEPN CCCCCCCCCCCCCCC	23.07	26060331
159	Acetylation	PVIEGDLKPAKHGTR CCCCCCCCCCCCCCE	47.90	24062335
165	Phosphorylation	LKPAKHGTRFFFWTV CCCCCCCCEEEEEEC	24.83	24719451
171	Phosphorylation	GTRFFFWTV------ CCEEEEEEC------	15.92	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUA8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUA8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUA8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUA8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.