DHX15_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX15_MOUSE
• UniProt AC: O35286
• Protein Name: Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 {ECO:0000250|UniProtKB:O43143}
• Gene Name: Dhx15
• Organism: Mus musculus (Mouse).
• Sequence Length: 795
• Subcellular Localization: Nucleus . Nucleus, nucleolus .
• Protein Description: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity)..
• Protein Sequence: MSKRHRLDLGEDYPSGKKRAGTDGKDRERDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHTGHTGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQSKEYSQY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RLDLGEDYPSGKKRA CCCCCCCCCCCCCCC	8.59	25159016
15	Phosphorylation	DLGEDYPSGKKRAGT CCCCCCCCCCCCCCC	57.95	28066266
17	Acetylation	GEDYPSGKKRAGTDG CCCCCCCCCCCCCCC	43.34	23806337
18	Acetylation	EDYPSGKKRAGTDGK CCCCCCCCCCCCCCC	51.51	7296671
37	Phosphorylation	DRDREDRSKDRDRER HCCHHHHHHHHHHHH	51.75	29899451
132	Ubiquitination	PRYYDILKKRLQLPV HHHHHHHHHHCCCCC	35.86	22790023
147	Phosphorylation	WEYKDRFTDILVRHQ EEEHHHHHHHEEECC	24.03	27180971
155	Phosphorylation	DILVRHQSFVLVGET HHEEECCEEEEEECC	15.93	27841257
180	Phosphorylation	WCVEYMRSLPGPKRG HHHHHHHCCCCCCCC	23.53	25159016
190	S-nitrosocysteine	GPKRGVACTQPRRVA CCCCCCCCCCHHHHH	3.18	-
190	S-nitrosylation	GPKRGVACTQPRRVA CCCCCCCCCCHHHHH	3.18	21278135
190	Glutathionylation	GPKRGVACTQPRRVA CCCCCCCCCCHHHHH	3.18	24333276
226	S-nitrosocysteine	YSIRFEDCSSAKTIL CEEEECCCCCCHHHH	2.45	-
226	S-nitrosylation	YSIRFEDCSSAKTIL CEEEECCCCCCHHHH	2.45	20925432
226	Glutathionylation	YSIRFEDCSSAKTIL CEEEECCCCCCHHHH	2.45	24333276
234	Acetylation	SSAKTILKYMTDGML CCCHHHHHHHHHHHH	29.17	22826441
284	Phosphorylation	KEVVRQRSDLKVIVM HHHHHHCCCCEEEEE	38.67	-
445	Malonylation	DPGFAKQKVYNPRIR CCCCCCCCCCCCCCC	46.08	26320211
488	Acetylation	CFRLYTEKAYKTEMQ EEEEEECCHHHHHCC	49.57	-
488	Ubiquitination	CFRLYTEKAYKTEMQ EEEEEECCHHHHHCC	49.57	22790023
491	Ubiquitination	LYTEKAYKTEMQDNT EEECCHHHHHCCCCC	42.75	22790023
499	Phosphorylation	TEMQDNTYPEILRSN HHCCCCCCHHHHHCC	12.72	-
516	Ubiquitination	SVVLQLKKLGIDDLV HHHHHHHHHCCCCEE	61.61	22790023
645	Phosphorylation	HESVQWCYDNFINYR CCCHHHHHHCCCCHH	15.80	22817900
751	Phosphorylation	KNYIRTCTDIKPEWL CCHHCCCCCCCHHHH	39.90	22871156
754	Acetylation	IRTCTDIKPEWLVKI HCCCCCCCHHHHHHH	39.43	23236377
769	Phosphorylation	APQYYDMSNFPQCEA CCHHCCCCCCCHHHH	32.21	25338131
786	Ubiquitination	QLDRIIAKLQSKEYS HHHHHHHHHHCCHHH	36.33	22790023
790	Ubiquitination	IIAKLQSKEYSQY-- HHHHHHCCHHHCC--	47.94	-
793	Phosphorylation	KLQSKEYSQY----- HHHCCHHHCC-----	24.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX15_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHX15_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX15_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DHX15_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.