GDIB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDIB_MOUSE
• UniProt AC: Q61598
• Protein Name: Rab GDP dissociation inhibitor beta
• Gene Name: Gdi2
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them..
• Protein Sequence: MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDQNPYYGGESASITPLEDLYKRFKLPGQPPASMGRGRDWNVDLIPKFLMANGQLVKMLLFTEVTRYMDFKVIEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGVDPKKTSMRDVYKKFDLGQDVIDFTGHSLALYRTDDYLDQPCCETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVVGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLFVPKDLGTDSQIFISRAYDATTHFETTCDDIKDIYKRMTGSEFDFEEMKRKKNDIYGED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNEEYDVI -------CCCCCCEE	14.90	-
29	Ubiquitination	IMSVNGKKVLHMDQN HHCCCCEEEEECCCC	51.97	-
38	Phosphorylation	LHMDQNPYYGGESAS EECCCCCCCCCCCCC	23.45	22817900
39	Phosphorylation	HMDQNPYYGGESASI ECCCCCCCCCCCCCC	21.66	22817900
54	Acetylation	TPLEDLYKRFKLPGQ CCHHHHHHHCCCCCC	59.67	132935
54	Ubiquitination	TPLEDLYKRFKLPGQ CCHHHHHHHCCCCCC	59.67	-
57	Ubiquitination	EDLYKRFKLPGQPPA HHHHHHCCCCCCCCC	58.78	-
57	Acetylation	EDLYKRFKLPGQPPA HHHHHHCCCCCCCCC	58.78	23806337
57	Succinylation	EDLYKRFKLPGQPPA HHHHHHCCCCCCCCC	58.78	-
57	Succinylation	EDLYKRFKLPGQPPA HHHHHHCCCCCCCCC	58.78	23806337
65	Phosphorylation	LPGQPPASMGRGRDW CCCCCCCCCCCCCCC	27.78	28066266
68	Methylation	QPPASMGRGRDWNVD CCCCCCCCCCCCCCC	28.47	-
79	Ubiquitination	WNVDLIPKFLMANGQ CCCCHHHHHHHHCCC	44.10	-
112	Ubiquitination	IEGSFVYKGGKIYKV EEEEEEEECCEEEEC	56.75	-
112	Acetylation	IEGSFVYKGGKIYKV EEEEEEEECCEEEEC	56.75	23236377
112	Succinylation	IEGSFVYKGGKIYKV EEEEEEEECCEEEEC	56.75	23954790
117	Phosphorylation	VYKGGKIYKVPSTEA EEECCEEEECCCHHH	14.93	-
129	Phosphorylation	TEAEALASSLMGLFE HHHHHHHHHHHHHHH	25.51	29472430
130	Phosphorylation	EAEALASSLMGLFEK HHHHHHHHHHHHHHH	19.44	26745281
137	Acetylation	SLMGLFEKRRFRKFL HHHHHHHHHCHHHEE	41.35	23954790
142	Ubiquitination	FEKRRFRKFLVYVAN HHHHCHHHEEEEEEC	40.10	-
153	Ubiquitination	YVANFDEKDPRTFEG EEECCCCCCCCCCCC	74.91	-
164	Succinylation	TFEGVDPKKTSMRDV CCCCCCCCCCCHHHH	65.31	23954790
164	Ubiquitination	TFEGVDPKKTSMRDV CCCCCCCCCCCHHHH	65.31	-
164	Malonylation	TFEGVDPKKTSMRDV CCCCCCCCCCCHHHH	65.31	26320211
164	Acetylation	TFEGVDPKKTSMRDV CCCCCCCCCCCHHHH	65.31	23806337
174	Acetylation	SMRDVYKKFDLGQDV CHHHHHHHCCCCCCC	26.82	22826441
174	Ubiquitination	SMRDVYKKFDLGQDV CHHHHHHHCCCCCCC	26.82	-
210	Ubiquitination	CETINRIKLYSESLA HHHHHHHHHHHHHHH	37.83	-
221	Ubiquitination	ESLARYGKSPYLYPL HHHHHHCCCCCEECC	39.05	-
229	Phosphorylation	SPYLYPLYGLGELPQ CCCEECCCCCCCCCC	13.05	18563927
242	Phosphorylation	PQGFARLSAIYGGTY CCHHHHHHHHHCCCE	13.68	25367039
245	Phosphorylation	FARLSAIYGGTYMLN HHHHHHHHCCCEECC	14.82	25367039
248	Phosphorylation	LSAIYGGTYMLNKPI HHHHHCCCEECCCCH	11.03	25367039
249	Phosphorylation	SAIYGGTYMLNKPIE HHHHCCCEECCCCHH	11.68	25367039
269	Ubiquitination	NGKVVGVKSEGEIAR CCEEEEECCHHHHHH	36.54	-
269	Succinylation	NGKVVGVKSEGEIAR CCEEEEECCHHHHHH	36.54	23806337
269	Acetylation	NGKVVGVKSEGEIAR CCEEEEECCHHHHHH	36.54	23806337
269	Malonylation	NGKVVGVKSEGEIAR CCEEEEECCHHHHHH	36.54	26320211
278	Ubiquitination	EGEIARCKQLICDPS HHHHHHHEEEECCHH	42.45	-
288	Acetylation	ICDPSYVKDRVEKVG ECCHHHHHHHHHHHH	31.42	22826441
293	Acetylation	YVKDRVEKVGQVIRV HHHHHHHHHHHHHHH	49.13	22826441
293	Ubiquitination	YVKDRVEKVGQVIRV HHHHHHHHHHHHHHH	49.13	-
309	Acetylation	CILSHPIKNTNDANS HHHCCCCCCCCCCCC	63.27	-
309	Malonylation	CILSHPIKNTNDANS HHHCCCCCCCCCCCC	63.27	26320211
317	S-nitrosocysteine	NTNDANSCQIIIPQN CCCCCCCCEEEEEHH	3.19	-
317	S-nitrosylation	NTNDANSCQIIIPQN CCCCCCCCEEEEEHH	3.19	21278135
329	Acetylation	PQNQVNRKSDIYVCM EHHHCCCCCCEEEEE	47.48	-
333	Phosphorylation	VNRKSDIYVCMISFA CCCCCCEEEEEHHCC	7.81	25367039
360	Ubiquitination	VSTTVETKEPEKEIR EEEEECCCCCHHHHH	58.74	-
382	Phosphorylation	PIEQKFVSISDLFVP HHHHHCCCHHHCCCC	21.36	26643407
384	Phosphorylation	EQKFVSISDLFVPKD HHHCCCHHHCCCCCC	22.28	23984901
390	Ubiquitination	ISDLFVPKDLGTDSQ HHHCCCCCCCCCCCE	61.35	-
414	S-nitrosocysteine	TTHFETTCDDIKDIY CCCEECHHHHHHHHH	6.05	-
414	S-nitrosylation	TTHFETTCDDIKDIY CCCEECHHHHHHHHH	6.05	20925432
414	Glutathionylation	TTHFETTCDDIKDIY CCCEECHHHHHHHHH	6.05	24333276
418	Acetylation	ETTCDDIKDIYKRMT ECHHHHHHHHHHHHH	45.10	22826441
418	Ubiquitination	ETTCDDIKDIYKRMT ECHHHHHHHHHHHHH	45.10	-
422	Acetylation	DDIKDIYKRMTGSEF HHHHHHHHHHHCCCC	35.71	23806337
425	Phosphorylation	KDIYKRMTGSEFDFE HHHHHHHHCCCCCHH	41.40	20139300
427	Phosphorylation	IYKRMTGSEFDFEEM HHHHHHCCCCCHHHH	26.39	22817900
435	Acetylation	EFDFEEMKRKKNDIY CCCHHHHHHHHCCCC	65.43	155633
435	Ubiquitination	EFDFEEMKRKKNDIY CCCHHHHHHHHCCCC	65.43	-
442	Phosphorylation	KRKKNDIYGED---- HHHHCCCCCCC----	19.82	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDIB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDIB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDIB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB6A_HUMAN	RAB6A	physical	7782346
RAB4A_HUMAN	RAB4A	physical	7782346
RAB2A_HUMAN	RAB2A	physical	7782346
RAB1A_HUMAN	RAB1A	physical	7782346

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.