RCL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCL1_MOUSE
• UniProt AC: Q9JJT0
• Protein Name: RNA 3'-terminal phosphate cyclase-like protein
• Gene Name: Rcl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 373
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity)..
• Protein Sequence: MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRRIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLEALLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKILRRGMPPGGGGEVLFSCPVRKVLKPVQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVSSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAVLPEDLGRNCAKLLLEEIYRGGCVDSTNQSLVLLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQVMFKVETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Ubiquitination	LFSCPVRKVLKPVQL EEECEECCCCCCEEC	52.75	-
231	Ubiquitination	YIYTDHMKGVSSGKS EEEECCCCCCCCCCC	53.38	-
281	Ubiquitination	DLGRNCAKLLLEEIY HHCHHHHHHHHHHHH	41.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RCL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.