AS3MT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AS3MT_MOUSE
• UniProt AC: Q91WU5
• Protein Name: Arsenite methyltransferase
• Gene Name: As3mt
• Organism: Mus musculus (Mouse).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)..
• Protein Sequence: MAASRDADEIHKDVQNYYGNVLKTSADLQTNACVTRAKPVPSYIRESLQNVHEDVSSRYYGCGLTVPERLENCRILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTEVQVEVAKTYLEHHMEKFGFQAPNVTFLHGRIEKLAEAGIQSESYDIVISNCVINLVPDKQQVLQEVYRVLKHGGELYFSDVYASLEVPEDIKSHKVLWGECLGGALYWKDLAIIAQKIGFCPPRLVTADIITVENKELEGVLGDCRFVSATFRLFKLPKTEPAERCRVVYNGGIKGHEKELIFDANFTFKEGEAVAVDEETAAVLKNSRFAPDFLFTPVDASLPAPQGRSELETKVLIRDPFKLAEDSDKMKPRHAPEGTGGCCGKRKNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	RDADEIHKDVQNYYG CCHHHHHHHHHHHHH	66.32	22790023
33	S-nitrosocysteine	ADLQTNACVTRAKPV CCCCCCCCCCCCCCC	3.31	-
33	S-nitrosylation	ADLQTNACVTRAKPV CCCCCCCCCCCCCCC	3.31	21278135
38	Ubiquitination	NACVTRAKPVPSYIR CCCCCCCCCCCHHHH	43.17	27667366
47	Phosphorylation	VPSYIRESLQNVHED CCHHHHHHHHHHCCC	25.96	-
62	S-palmitoylation	VSSRYYGCGLTVPER HHHCCCCCCCCHHHH	2.03	28526873
213	Phosphorylation	ECLGGALYWKDLAII HHHHHHHHHHHHHHH	15.18	20469934
251	S-palmitoylation	LEGVLGDCRFVSATF ECCHHCCCCEEEEEE	3.27	28526873
336	Phosphorylation	LPAPQGRSELETKVL CCCCCCCCHHCEEEE	54.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AS3MT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AS3MT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AS3MT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AS3MT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.