dbPTM

SI1L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SI1L1_MOUSE
UniProt AC	Q8C0T5
Protein Name	Signal-induced proliferation-associated 1-like protein 1
Gene Name	Sipa1l1
Organism	Mus musculus (Mouse).
Sequence Length	1782
Subcellular Localization	Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons
Protein Description	Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)..
Protein Sequence	MTSLKRSQTERPVTADRASVVSTDGAPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGDSFFDLLKGYKDDRSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESALSSHCTNAGVAVLEVPKESLMLHLDRVKRYTVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAKDYNKAMEFDCLLGISSEFIVLIEQETKSVAFNCSCRDVIGWTSSDTSLKIFYERGECVSVESFISGEDIKEIVRRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYQMNEGISYEFKFPFRNNNKWQRNASKGAHSPQVPSQLQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDISGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGPSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKAESSLSLDIHSKSQGGSSPLSRENSTFSINDAASHTSTMSSRHSASPVVFSSARSSPKEELHPTASSQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLQASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHALSSPQSPFPTTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPIPDPGLMPLPDAASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSKDPSPTLASKVDQLEGMLKMLREDLKKEKEDKAQLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	TSLKRSQTERPVTAD CCCCCCCCCCCCCCC	34.90	29899451
35	Phosphorylation	KVHTDDFYMRRFRSQ CCCCCHHHHHHHHHC	9.19	29514104
41	Phosphorylation	FYMRRFRSQNGSLGS HHHHHHHHCCCCCCC	25.86	22871156
59	O-linked_Glycosylation	AAVGPPRSEGPHHIT CCCCCCCCCCCCCCC	53.32	55413807
59	Phosphorylation	AAVGPPRSEGPHHIT CCCCCCCCCCCCCCC	53.32	22871156
66	Phosphorylation	SEGPHHITSTPGVPK CCCCCCCCCCCCCCC	23.38	22871156
93	Phosphorylation	RKENVKESSRSSQEI CHHCCCCCCCCCCHH	25.90	30635358
94	Phosphorylation	KENVKESSRSSQEIE HHCCCCCCCCCCHHH	36.95	30635358
96	Phosphorylation	NVKESSRSSQEIETS CCCCCCCCCCHHHHH	38.02	30635358
97	Phosphorylation	VKESSRSSQEIETSS CCCCCCCCCHHHHHH	30.62	25521595
102	Phosphorylation	RSSQEIETSSCLESL CCCCHHHHHHHHHHH	31.44	29899451
110	Phosphorylation	SSCLESLSSKGSPVS HHHHHHHHCCCCCCC	39.00	28973931
114	Phosphorylation	ESLSSKGSPVSQGSS HHHHCCCCCCCCCCC	26.35	25521595
120	Phosphorylation	GSPVSQGSSVSLNSN CCCCCCCCCEECCCC	21.67	29899451
143	Phosphorylation	QNTLKNKTGPAESMD HHHHCCCCCCCCCCC	58.76	20531401
148	Phosphorylation	NKTGPAESMDSRFLM CCCCCCCCCCHHHCC	29.96	20531401
151	Phosphorylation	GPAESMDSRFLMPEA CCCCCCCHHHCCCCC	19.11	20531401
159	Phosphorylation	RFLMPEAYPSSPRKA HHCCCCCCCCCHHHH	11.28	29233185
161	Phosphorylation	LMPEAYPSSPRKALR CCCCCCCCCHHHHHH	40.05	26824392
162	Phosphorylation	MPEAYPSSPRKALRR CCCCCCCCHHHHHHH	24.99	26824392
174	Phosphorylation	LRRIRQRSNSDITIS HHHHHHHCCCCCEEE	32.14	26745281
176	Phosphorylation	RIRQRSNSDITISEL HHHHHCCCCCEEEEE	31.47	26745281
179	Phosphorylation	QRSNSDITISELDVD HHCCCCCEEEEECCC	24.36	26745281
181	Phosphorylation	SNSDITISELDVDSF CCCCCEEEEECCCCC	24.37	25195567
187	Phosphorylation	ISELDVDSFDECISP EEEECCCCCHHHCCC	34.15	30635358
193	Phosphorylation	DSFDECISPTYKSGP CCCHHHCCCCCCCCC	23.89	30635358
195	Phosphorylation	FDECISPTYKSGPSL CHHHCCCCCCCCCCC	36.47	30635358
196	Phosphorylation	DECISPTYKSGPSLH HHHCCCCCCCCCCCC	13.41	30635358
206	Phosphorylation	GPSLHREYGSTSSID CCCCCCHHCCCCCCC	19.14	21082442
208	Phosphorylation	SLHREYGSTSSIDKQ CCCCHHCCCCCCCCC	24.98	25521595
209	Phosphorylation	LHREYGSTSSIDKQG CCCHHCCCCCCCCCC	23.33	23684622
210	Phosphorylation	HREYGSTSSIDKQGT CCHHCCCCCCCCCCC	27.30	27087446
211	Phosphorylation	REYGSTSSIDKQGTS CHHCCCCCCCCCCCC	34.59	25521595
217	Phosphorylation	SSIDKQGTSGDSFFD CCCCCCCCCCCCHHH	27.35	28066266
218	Phosphorylation	SIDKQGTSGDSFFDL CCCCCCCCCCCHHHH	47.64	28066266
221	Phosphorylation	KQGTSGDSFFDLLKG CCCCCCCCHHHHHHC	31.19	28066266
234	Phosphorylation	KGYKDDRSDRGPTPT HCCCCCCCCCCCCCC	38.36	25266776
239	Phosphorylation	DRSDRGPTPTKLSDF CCCCCCCCCCCHHHE	46.55	25266776
241	Phosphorylation	SDRGPTPTKLSDFLI CCCCCCCCCHHHEEE	47.28	29550500
244	Phosphorylation	GPTPTKLSDFLITGG CCCCCCHHHEEECCC	28.07	23984901
249	Phosphorylation	KLSDFLITGGGKGSG CHHHEEECCCCCCCC	31.74	26239621
255	Phosphorylation	ITGGGKGSGFSLDVI ECCCCCCCCCCEEEC	39.90	27087446
258	Phosphorylation	GGKGSGFSLDVIDGP CCCCCCCCEEECCCC	27.47	28973931
286	Phosphorylation	EKPLKRRSKSETGDS CCCCCCCCCCCCCCH	44.56	23684622
288	Phosphorylation	PLKRRSKSETGDSSI CCCCCCCCCCCCHHH	41.45	26824392
290	Phosphorylation	KRRSKSETGDSSIFR CCCCCCCCCCHHHHH	54.07	23684622
293	Phosphorylation	SKSETGDSSIFRKLR CCCCCCCHHHHHHHH	27.03	25619855
294	Phosphorylation	KSETGDSSIFRKLRN CCCCCCHHHHHHHHC	30.41	25619855
310	Phosphorylation	KGEELGKSSDLEDNR CCHHCCCCCCCCCCC	27.56	25619855
311	Phosphorylation	GEELGKSSDLEDNRS CHHCCCCCCCCCCCC	50.10	25619855
318	Phosphorylation	SDLEDNRSEDSVRPW CCCCCCCCCCCCCCC	52.59	25266776
321	Phosphorylation	EDNRSEDSVRPWTCP CCCCCCCCCCCCCCC	18.90	25195567
326	Phosphorylation	EDSVRPWTCPKCFAH CCCCCCCCCCCHHCC	22.93	26745281
359	Phosphorylation	NVIKRRNTTTGASAA CHHHCCCCCCHHHHH	24.75	25777480
360	Phosphorylation	VIKRRNTTTGASAAA HHHCCCCCCHHHHHH	27.12	25777480
361	Phosphorylation	IKRRNTTTGASAAAV HHCCCCCCHHHHHHH	28.81	25777480
364	Phosphorylation	RNTTTGASAAAVASL CCCCCHHHHHHHHHH	21.56	25777480
370	Phosphorylation	ASAAAVASLVSGPLS HHHHHHHHHHHCCCC	23.78	25777480
373	Phosphorylation	AAVASLVSGPLSHSA HHHHHHHHCCCCCCC	39.73	25777480
377	Phosphorylation	SLVSGPLSHSASFSS HHHHCCCCCCCCCCC	20.66	29109428
379	Phosphorylation	VSGPLSHSASFSSPM HHCCCCCCCCCCCCC	23.41	25777480
381	Phosphorylation	GPLSHSASFSSPMGS CCCCCCCCCCCCCCC	28.77	29109428
383	Phosphorylation	LSHSASFSSPMGSTE CCCCCCCCCCCCCCC	30.91	23984901
384	Phosphorylation	SHSASFSSPMGSTED CCCCCCCCCCCCCCH	19.52	26745281
388	Phosphorylation	SFSSPMGSTEDLNSK CCCCCCCCCCHHCCC	23.52	26745281
389	Phosphorylation	FSSPMGSTEDLNSKG CCCCCCCCCHHCCCC	27.99	23984901
394	Phosphorylation	GSTEDLNSKGSLGMD CCCCHHCCCCCCCCC	45.77	26745281
397	Phosphorylation	EDLNSKGSLGMDQGD CHHCCCCCCCCCCCC	26.03	29109428
658	Dimethylation	LKGFEKYRAQLDTKT HCCHHHHHEECCCCC	27.25	-
658	Methylation	LKGFEKYRAQLDTKT HCCHHHHHEECCCCC	27.25	58856431
665	Phosphorylation	RAQLDTKTDSTGTHS HEECCCCCCCCCCCC	36.96	25293948
667	Phosphorylation	QLDTKTDSTGTHSLY ECCCCCCCCCCCCEE	33.69	25293948
668	Phosphorylation	LDTKTDSTGTHSLYT CCCCCCCCCCCCEEE	49.24	25293948
670	Phosphorylation	TKTDSTGTHSLYTTY CCCCCCCCCCEEEEE	14.37	25293948
672	Phosphorylation	TDSTGTHSLYTTYKD CCCCCCCCEEEEECC	23.94	25293948
674	Phosphorylation	STGTHSLYTTYKDYE CCCCCCEEEEECCCE	10.47	25293948
675	Phosphorylation	TGTHSLYTTYKDYEI CCCCCEEEEECCCEE	29.01	25293948
676	Phosphorylation	GTHSLYTTYKDYEIM CCCCEEEEECCCEEE	18.28	25293948
677	Phosphorylation	THSLYTTYKDYEIMF CCCEEEEECCCEEEE	8.28	25293948
955	Phosphorylation	GCESVEMTLRRNGLG CCCEEEEEHHHCCCC	12.01	22817900
1036	Phosphorylation	DDCTPRRSCSETYRM CCCCCCCCCCCCCCC	24.23	29899451
1073	Phosphorylation	NKWQRNASKGAHSPQ CCCCCCCCCCCCCCC	34.86	-
1078	Phosphorylation	NASKGAHSPQVPSQL CCCCCCCCCCCCHHH	19.25	26745281
1083	Phosphorylation	AHSPQVPSQLQSPMT CCCCCCCHHHCCCCH	44.67	29899451
1087	Phosphorylation	QVPSQLQSPMTSRLN CCCHHHCCCCHHCCC	25.82	26239621
1090	Phosphorylation	SQLQSPMTSRLNAGK HHHCCCCHHCCCCCC	17.68	29550500
1091	Phosphorylation	QLQSPMTSRLNAGKG HHCCCCHHCCCCCCC	28.63	29550500
1114	Phosphorylation	RAANIPRSISSDGRP HHHCCCCCCCCCCCC	22.82	25266776
1116	Phosphorylation	ANIPRSISSDGRPLE HCCCCCCCCCCCCCC	24.51	26824392
1117	Phosphorylation	NIPRSISSDGRPLER CCCCCCCCCCCCCCC	42.27	26745281
1127	Phosphorylation	RPLERRLSPGSDIYV CCCCCCCCCCCCEEE	25.96	26824392
1130	Phosphorylation	ERRLSPGSDIYVTVS CCCCCCCCCEEEEHH	24.99	26239621
1133	Phosphorylation	LSPGSDIYVTVSSMA CCCCCCEEEEHHHHH	8.61	26745281
1135	Phosphorylation	PGSDIYVTVSSMALA CCCCEEEEHHHHHHH	9.56	26745281
1137	Phosphorylation	SDIYVTVSSMALARS CCEEEEHHHHHHHHH	12.67	26745281
1138	Phosphorylation	DIYVTVSSMALARSQ CEEEEHHHHHHHHHH	12.07	26745281
1144	Phosphorylation	SSMALARSQCRNSPS HHHHHHHHHHCCCCC	28.20	25619855
1149	Phosphorylation	ARSQCRNSPSNLSSS HHHHHCCCCCCCCCC	15.45	25619855
1151	Phosphorylation	SQCRNSPSNLSSSSE HHHCCCCCCCCCCCC	50.66	25619855
1154	Phosphorylation	RNSPSNLSSSSETGS CCCCCCCCCCCCCCC	32.21	25619855
1155	Phosphorylation	NSPSNLSSSSETGSG CCCCCCCCCCCCCCC	40.84	25619855
1156	Phosphorylation	SPSNLSSSSETGSGG CCCCCCCCCCCCCCC	28.90	25619855
1157	Phosphorylation	PSNLSSSSETGSGGG CCCCCCCCCCCCCCC	40.92	26745281
1165	Phosphorylation	ETGSGGGTYRQKSMP CCCCCCCCCCCCCCC	20.85	29514104
1166	Phosphorylation	TGSGGGTYRQKSMPE CCCCCCCCCCCCCCC	17.83	22817900
1170	Phosphorylation	GGTYRQKSMPEGFGV CCCCCCCCCCCCCCC	31.09	25521595
1178	Phosphorylation	MPEGFGVSRRSPASI CCCCCCCCCCCCHHC	23.50	22324799
1181	Phosphorylation	GFGVSRRSPASIDRQ CCCCCCCCCHHCCCC	24.57	27087446
1184	Phosphorylation	VSRRSPASIDRQNTQ CCCCCCHHCCCCCCC	28.53	22324799
1190	Phosphorylation	ASIDRQNTQSDISGS HHCCCCCCCCCCCCC	22.55	25521595
1192	Phosphorylation	IDRQNTQSDISGSGK CCCCCCCCCCCCCCC	34.57	28285833
1195	Phosphorylation	QNTQSDISGSGKSTP CCCCCCCCCCCCCCC	31.71	29899451
1197	Phosphorylation	TQSDISGSGKSTPSW CCCCCCCCCCCCCCC	35.94	29514104
1200	Phosphorylation	DISGSGKSTPSWQRS CCCCCCCCCCCCCCC	49.42	29899451
1201	Phosphorylation	ISGSGKSTPSWQRSE CCCCCCCCCCCCCCC	25.48	23684622
1207	Phosphorylation	STPSWQRSEDSLADQ CCCCCCCCCCHHHHH	30.56	28973931
1210	Phosphorylation	SWQRSEDSLADQMEP CCCCCCCHHHHHCCC	22.77	29899451
1234	Phosphorylation	VLPAFRESPSGRLMR HHHHHHHCCCCCCCC	21.80	26824392
1236	Phosphorylation	PAFRESPSGRLMRQD HHHHHCCCCCCCCCC	45.91	26745281
1249	Phosphorylation	QDPVVHLSPNKQGHS CCCEEECCCCCCCCC	16.14	25521595
1256	Phosphorylation	SPNKQGHSDSHYSSH CCCCCCCCCCCCCCC	47.86	22802335
1258	Phosphorylation	NKQGHSDSHYSSHSS CCCCCCCCCCCCCCC	27.60	22802335
1260	Phosphorylation	QGHSDSHYSSHSSSN CCCCCCCCCCCCCCC	18.80	22802335
1278	Phosphorylation	SNASSAHSDEKWYDG CCCCCCCCCCCCCCC	47.37	25338131
1294	Phosphorylation	RTESDLNSYNYLQGT CCHHHHHHCCHHCCC	23.27	22802335
1295	Phosphorylation	TESDLNSYNYLQGTS CHHHHHHCCHHCCCC	13.52	22802335
1297	Phosphorylation	SDLNSYNYLQGTSAD HHHHHCCHHCCCCCC	7.68	22802335
1301	Phosphorylation	SYNYLQGTSADSGID HCCHHCCCCCCCCCC	14.05	22802335
1302	Phosphorylation	YNYLQGTSADSGIDT CCHHCCCCCCCCCCC	36.58	22802335
1305	Phosphorylation	LQGTSADSGIDTASY HCCCCCCCCCCCCCC	37.05	22802335
1309	Phosphorylation	SADSGIDTASYGPSH CCCCCCCCCCCCCCC	18.64	22802335
1311	Phosphorylation	DSGIDTASYGPSHGS CCCCCCCCCCCCCCC	32.49	22802335
1312	Phosphorylation	SGIDTASYGPSHGST CCCCCCCCCCCCCCC	30.50	22802335
1315	Phosphorylation	DTASYGPSHGSTASL CCCCCCCCCCCCCCC	35.80	22802335
1318	Phosphorylation	SYGPSHGSTASLGAS CCCCCCCCCCCCCCC	18.51	22802335
1319	Phosphorylation	YGPSHGSTASLGAST CCCCCCCCCCCCCCC	25.51	22802335
1321	Phosphorylation	PSHGSTASLGASTSS CCCCCCCCCCCCCCC	27.68	22802335
1325	Phosphorylation	STASLGASTSSPRSG CCCCCCCCCCCCCCC	27.33	22802335
1326	Phosphorylation	TASLGASTSSPRSGP CCCCCCCCCCCCCCC	32.46	22802335
1327	Phosphorylation	ASLGASTSSPRSGPG CCCCCCCCCCCCCCC	35.53	22802335
1328	Phosphorylation	SLGASTSSPRSGPGK CCCCCCCCCCCCCCC	25.15	22817900
1344	Phosphorylation	KVAPLWHSSSEVLSL CCCCCCCCHHHHHHH	24.79	21082442
1345	Phosphorylation	VAPLWHSSSEVLSLA CCCCCCCHHHHHHHH	20.03	25521595
1346	Phosphorylation	APLWHSSSEVLSLAD CCCCCCHHHHHHHHH	34.44	22942356
1350	Phosphorylation	HSSSEVLSLADRTLE CCHHHHHHHHHHHHH	27.04	26745281
1355	Phosphorylation	VLSLADRTLETEGHG HHHHHHHHHHCCCCC	29.50	-
1369	Phosphorylation	GMDRKAESSLSLDIH CCCCCCCCCCEEEEE	41.25	26824392
1370	Phosphorylation	MDRKAESSLSLDIHS CCCCCCCCCEEEEEC	17.30	26824392
1372	Phosphorylation	RKAESSLSLDIHSKS CCCCCCCEEEEECCC	26.41	26824392
1377	Phosphorylation	SLSLDIHSKSQGGSS CCEEEEECCCCCCCC	34.04	28059163
1379	Phosphorylation	SLDIHSKSQGGSSPL EEEEECCCCCCCCCC	36.75	24719451
1383	Phosphorylation	HSKSQGGSSPLSREN ECCCCCCCCCCCCCC	35.29	24453211
1384	Phosphorylation	SKSQGGSSPLSRENS CCCCCCCCCCCCCCC	32.89	26824392
1387	Phosphorylation	QGGSSPLSRENSTFS CCCCCCCCCCCCCEE	40.72	28418008
1391	Phosphorylation	SPLSRENSTFSINDA CCCCCCCCCEEHHHH	26.52	19060867
1400	O-linked_Glycosylation	FSINDAASHTSTMSS EEHHHHHHCCCCCCC	29.08	55413783
1400	Phosphorylation	FSINDAASHTSTMSS EEHHHHHHCCCCCCC	29.08	23684622
1402	O-linked_Glycosylation	INDAASHTSTMSSRH HHHHHHCCCCCCCCC	24.33	22645316
1402	Phosphorylation	INDAASHTSTMSSRH HHHHHHCCCCCCCCC	24.33	23684622
1403	O-linked_Glycosylation	NDAASHTSTMSSRHS HHHHHCCCCCCCCCC	19.38	22645316
1403	Phosphorylation	NDAASHTSTMSSRHS HHHHHCCCCCCCCCC	19.38	-
1410	Phosphorylation	STMSSRHSASPVVFS CCCCCCCCCCCEEEE	29.36	25521595
1412	Phosphorylation	MSSRHSASPVVFSSA CCCCCCCCCEEEECC	22.65	25521595
1417	Phosphorylation	SASPVVFSSARSSPK CCCCEEEECCCCCCH	16.10	25619855
1418	Phosphorylation	ASPVVFSSARSSPKE CCCEEEECCCCCCHH	19.08	25619855
1421	Phosphorylation	VVFSSARSSPKEELH EEEECCCCCCHHHHC	51.19	23684622
1422	Phosphorylation	VFSSARSSPKEELHP EEECCCCCCHHHHCC	34.14	21082442
1430	Phosphorylation	PKEELHPTASSQLAP CHHHHCCCCCHHCCC	28.55	26239621
1432	Phosphorylation	EELHPTASSQLAPSF HHHCCCCCHHCCCCC	22.54	26239621
1433	Phosphorylation	ELHPTASSQLAPSFS HHCCCCCHHCCCCCC	27.09	26239621
1438	Phosphorylation	ASSQLAPSFSSSSSS CCHHCCCCCCCCCCC	31.96	25777480
1440	O-linked_Glycosylation	SQLAPSFSSSSSSSS HHCCCCCCCCCCCCC	33.38	55413791
1440	Phosphorylation	SQLAPSFSSSSSSSS HHCCCCCCCCCCCCC	33.38	25777480
1441	Phosphorylation	QLAPSFSSSSSSSSG HCCCCCCCCCCCCCC	32.03	25777480
1442	Phosphorylation	LAPSFSSSSSSSSGP CCCCCCCCCCCCCCC	32.80	25777480
1443	Phosphorylation	APSFSSSSSSSSGPR CCCCCCCCCCCCCCC	35.87	25777480
1444	Phosphorylation	PSFSSSSSSSSGPRT CCCCCCCCCCCCCCC	35.87	25777480
1445	Phosphorylation	SFSSSSSSSSGPRTF CCCCCCCCCCCCCCC	30.39	25777480
1446	Phosphorylation	FSSSSSSSSGPRTFY CCCCCCCCCCCCCCC	41.06	25777480
1447	Phosphorylation	SSSSSSSSGPRTFYP CCCCCCCCCCCCCCC	55.56	25777480
1451	Phosphorylation	SSSSGPRTFYPRQGA CCCCCCCCCCCCCCC	30.56	22871156
1453	Phosphorylation	SSGPRTFYPRQGATS CCCCCCCCCCCCCCC	9.26	22871156
1467	Acetylation	SKYLIGWKKPEGTIN CEEECCCCCCCCCCC	53.92	133719
1487	Phosphorylation	DTRKRHQSDGNEIAH CCCHHCCCCCCHHHH	41.16	27087446
1495	Phosphorylation	DGNEIAHTRLRASTR CCCHHHHHHHHHHHC	23.52	19854140
1500	Phosphorylation	AHTRLRASTRDLQAS HHHHHHHHHCCCCCC	19.96	25338131
1507	Phosphorylation	STRDLQASPKPTSKS HHCCCCCCCCCCCCC	22.09	25521595
1507 (in isoform 2)	Phosphorylation	-	22.09	19144319
1511	Phosphorylation	LQASPKPTSKSTIEE CCCCCCCCCCCHHHH	55.71	26745281
1512	Phosphorylation	QASPKPTSKSTIEED CCCCCCCCCCHHHHH	32.89	26745281
1528	Phosphorylation	KKLIDLESPTPESQK HHHHCCCCCCHHHHH	41.17	27087446
1528 (in isoform 2)	Phosphorylation	-	41.17	19144319
1530	Phosphorylation	LIDLESPTPESQKNF HHCCCCCCHHHHHCC	49.30	25521595
1533	Phosphorylation	LESPTPESQKNFKFH CCCCCHHHHHCCEEE	47.89	27087446
1543	Phosphorylation	NFKFHALSSPQSPFP CCEEEECCCCCCCCC	40.53	25521595
1544	Phosphorylation	FKFHALSSPQSPFPT CEEEECCCCCCCCCC	28.01	25521595
1547	Phosphorylation	HALSSPQSPFPTTPT EECCCCCCCCCCCCC	31.71	27087446
1551	Phosphorylation	SPQSPFPTTPTSRRA CCCCCCCCCCCHHHH	45.87	26824392
1552	Phosphorylation	PQSPFPTTPTSRRAL CCCCCCCCCCHHHHH	25.47	28973931
1554	Phosphorylation	SPFPTTPTSRRALHR CCCCCCCCHHHHHHH	32.54	25619855
1555	Phosphorylation	PFPTTPTSRRALHRT CCCCCCCHHHHHHHH	22.44	25619855
1562	Phosphorylation	SRRALHRTLSDESIY HHHHHHHHCCCHHHH	21.62	25521595
1564	Phosphorylation	RALHRTLSDESIYSS HHHHHHCCCHHHHHH	38.42	24925903
1564 (in isoform 2)	Phosphorylation	-	38.42	19144319
1567	Phosphorylation	HRTLSDESIYSSQRE HHHCCCHHHHHHHHH	31.64	25521595
1569	Phosphorylation	TLSDESIYSSQREHF HCCCHHHHHHHHHHH	16.14	25619855
1570	Phosphorylation	LSDESIYSSQREHFF CCCHHHHHHHHHHHH	20.51	25619855
1571	Phosphorylation	SDESIYSSQREHFFT CCHHHHHHHHHHHHH	19.11	24925903
1578	Phosphorylation	SQREHFFTSRASLLD HHHHHHHHCHHHHHH	19.16	26239621
1579	O-linked_Glycosylation	QREHFFTSRASLLDQ HHHHHHHCHHHHHHH	22.23	55413799
1579	Phosphorylation	QREHFFTSRASLLDQ HHHHHHHCHHHHHHH	22.23	26239621
1580	Asymmetric dimethylarginine	REHFFTSRASLLDQA HHHHHHCHHHHHHHH	25.74	-
1580	Methylation	REHFFTSRASLLDQA HHHHHHCHHHHHHHH	25.74	24129315
1582	Phosphorylation	HFFTSRASLLDQALP HHHHCHHHHHHHHCC	28.49	26239621
1595	Phosphorylation	LPNDVLFSSTYPSLP CCCCEEEECCCCCCC	20.01	26745281
1596	Phosphorylation	PNDVLFSSTYPSLPK CCCEEEECCCCCCCC	25.32	29899451
1598	Phosphorylation	DVLFSSTYPSLPKSL CEEEECCCCCCCCCC	7.86	26745281
1600	Phosphorylation	LFSSTYPSLPKSLPL EEECCCCCCCCCCCC	47.06	26745281
1604	Phosphorylation	TYPSLPKSLPLRRPS CCCCCCCCCCCCCCC	33.02	29899451
1611	Phosphorylation	SLPLRRPSYTLGMKS CCCCCCCCEECCCHH	29.01	26824392
1612	Phosphorylation	LPLRRPSYTLGMKSL CCCCCCCEECCCHHH	14.52	28833060
1613	Phosphorylation	PLRRPSYTLGMKSLH CCCCCCEECCCHHHC	22.60	28833060
1618	Phosphorylation	SYTLGMKSLHGEFSA CEECCCHHHCCCCCC	19.39	25619855
1624	Phosphorylation	KSLHGEFSASDSSLT HHHCCCCCCCCCCCC	23.66	27087446
1626	Phosphorylation	LHGEFSASDSSLTDI HCCCCCCCCCCCCHH	36.51	27087446
1628	Phosphorylation	GEFSASDSSLTDIQE CCCCCCCCCCCHHHH	25.42	27087446
1629	Phosphorylation	EFSASDSSLTDIQET CCCCCCCCCCHHHHH	40.03	27087446
1631	Phosphorylation	SASDSSLTDIQETRR CCCCCCCCHHHHHCC	32.76	25619855
1636	Phosphorylation	SLTDIQETRRQPIPD CCCHHHHHCCCCCCC	18.12	25619855
1654	Phosphorylation	MPLPDAASDLDWSNL CCCCCCHHCCCHHHH	40.19	-
1674	Phosphorylation	AYEVQRASFFAASDE HHHHHHHHHEECCCC	24.08	26745281
1679	Phosphorylation	RASFFAASDENHRPL HHHHEECCCCCCCCC	41.87	26745281
1687	Phosphorylation	DENHRPLSAASNSDQ CCCCCCCCCCCCCHH	25.19	27087446
1690	Phosphorylation	HRPLSAASNSDQLEE CCCCCCCCCCHHHHH	36.26	27087446
1692	Phosphorylation	PLSAASNSDQLEEQA CCCCCCCCHHHHHHH	25.00	26239621
1705	Phosphorylation	QALVQMKSYSSKDPS HHHHHHHHHCCCCCC	25.55	25619855
1706	Phosphorylation	ALVQMKSYSSKDPSP HHHHHHHHCCCCCCC	16.08	25619855
1707	Phosphorylation	LVQMKSYSSKDPSPT HHHHHHHCCCCCCCC	37.69	26060331
1708	Phosphorylation	VQMKSYSSKDPSPTL HHHHHHCCCCCCCCH	32.61	27087446
1712	Phosphorylation	SYSSKDPSPTLASKV HHCCCCCCCCHHHHH	40.42	25521595
1714	Phosphorylation	SSKDPSPTLASKVDQ CCCCCCCCHHHHHHH	39.02	25619855
1717	Phosphorylation	DPSPTLASKVDQLEG CCCCCHHHHHHHHHH	36.00	25619855
1772	Phosphorylation	SDKLKKFTEWVFNTI HHHHHHHHHHHHHHH	37.51	22817900
1778	Phosphorylation	FTEWVFNTIDMS--- HHHHHHHHHCCC---	13.59	21183079
1782	Phosphorylation	VFNTIDMS------- HHHHHCCC-------	33.07	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1305	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
1309	T	Phosphorylation	Kinase	PLK2	P53351	Uniprot
1328	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1328	S	Phosphorylation	Kinase	CDK5	P49615	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1328	S	Phosphorylation		-
Phosphorylated at Ser-1328 by CDK5, creating a docking site for the POLO box domains of PLK2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SI1L1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SI1L1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SI1L1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1528, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1507, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1507, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1528 AND SER-1547, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1528, AND MASSSPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1528, AND MASSSPECTROMETRY.	16452087 [Abstract]

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