MD1L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MD1L1_MOUSE
• UniProt AC: Q9WTX8
• Protein Name: Mitotic spindle assembly checkpoint protein MAD1
• Gene Name: Mad1l1
• Organism: Mus musculus (Mouse).
• Sequence Length: 717
• Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore . Nucleus envelope . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole . Detected at the nucleus envelope during in
• Protein Description: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding..
• Protein Sequence: MEDLGENTTVLSSLRSLNNFISQRMEGTSGLDVSTSASGSLQKQYEYHMQLEERAEQIRSKSYLIQVEREKMQMELSHKRARVELERAASTNARNYEREVDRNQELLARIRQLQECEATAEEKMREQLERHRLCKQNLDAVSQQLREQEDSLASAREMISSLKGRVSELQLSAMDQKVQVKRLESEKQELKEQLELQQRKWQEANQKIQELQASQDERAEHEQKIKDLEQKLCLQEQDAAVVKSMKSELMRMPRMERELKRLHEENTHLREMKETNGLLTEELEGLQRKLSRQEKMQEALVDLELEKEKLLAKLQSWENLDQTMGLNLRTPEDLSRFVVELQQRELTLKEKNNSITSSARGLEKVQQQLQDEVRQANAQLLEERKKRETHEALARRLQKRNALLTKERDGMRAILGSYDSELTQTEYSTQLTQRLWEAEDMVQKVHAHSSEMEAQLSQALEELGVQKQRADTLEMELKMLKAQTSSAESSFSFCKEEVDALRLKVEELEGERSRLEQEKQVLEMQMEKLTLQGDYNQSRTKVLHMSLNPISMARQRQHEDHDRLQEECERLRGLVHALERGGPIPADLEAASSLPSSKEVAELRKQVESAELKNQRLKEVFQTKIQEFRKVCYTLTGYQIDVTTESQYRLTSRYAEHQTDCLIFKATGPSGSKMQLLETEFSRSVPELIELHLLQQDSIPAFLSALTIELFSRQTSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDLGENT -------CCCCCCCH	9.02	-
12	Phosphorylation	GENTTVLSSLRSLNN CCCHHHHHHHHHHHH	24.00	25159016
13	Phosphorylation	ENTTVLSSLRSLNNF CCHHHHHHHHHHHHH	24.52	25159016
16	Phosphorylation	TVLSSLRSLNNFISQ HHHHHHHHHHHHHHH	40.52	-
61	Acetylation	RAEQIRSKSYLIQVE HHHHHHCCHHHHHHH	33.02	23806337
77	Phosphorylation	EKMQMELSHKRARVE HHHHHHHHHHHHHHH	17.41	-
142	Phosphorylation	KQNLDAVSQQLREQE HHHHHHHHHHHHHHH	17.58	25338131
214	Phosphorylation	KIQELQASQDERAEH HHHHHHHCHHHHHHH	25.79	-
418	Phosphorylation	MRAILGSYDSELTQT HHHHHCCCCCCCCCH	22.99	22871156
420	Phosphorylation	AILGSYDSELTQTEY HHHCCCCCCCCCHHH	26.69	22871156
423	Phosphorylation	GSYDSELTQTEYSTQ CCCCCCCCCHHHHHH	29.41	22871156
428	Phosphorylation	ELTQTEYSTQLTQRL CCCCHHHHHHHHHHH	11.93	-
673	Ubiquitination	ATGPSGSKMQLLETE ECCCCCCHHHHHHHH	33.90	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MD1L1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MD1L1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MD1L1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	11438660
HDAC1_MOUSE	Hdac1	physical	15722557

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.