IPO5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPO5_MOUSE
• UniProt AC: Q8BKC5
• Protein Name: Importin-5
• Gene Name: Ipo5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1097
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation. [PubMed: 22730302]
• Protein Sequence: MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGRSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKICDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNMGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTNLNNMQRQLALEVIVTLSETAAAMLRKHTSLIAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPQRPWPDRQWGLCIFDDIVEHCSPASFKYAEYFISPMLQYVCDNSPEVRQAAAYGLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFSYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAAEQQ ------CCHHHHHHH	19.67	-
12	Phosphorylation	AAEQQQFYLLLGNLL HHHHHHHHHHHHHCC	7.66	29233185
27	Ubiquitination	SPDNVVRKQAEETYE CCCHHHHHHHHHHHH	42.10	22790023
40	Phosphorylation	YENIPGRSKITFLLQ HHCCCCHHHHHHHHH	34.03	30635358
41	Acetylation	ENIPGRSKITFLLQA HCCCCHHHHHHHHHH	44.39	22826441
108	Ubiquitination	TQSSMRKKICDIAAE CCHHHHHHHHHHHHH	37.90	22790023
266	S-nitrosocysteine	LQLSLKLCGDTNLNN HHHHHHHHCCCCCHH	4.42	-
266	S-palmitoylation	LQLSLKLCGDTNLNN HHHHHHHHCCCCCHH	4.42	28526873
266	S-nitrosylation	LQLSLKLCGDTNLNN HHHHHHHHCCCCCHH	4.42	21278135
441	Acetylation	FQKKFHEKVIAALLQ HHHHHHHHHHHHHHH	30.30	22826441
449	Phosphorylation	VIAALLQTMEDQGNQ HHHHHHHHHHHHCCH	23.61	25159016
476	Phosphorylation	FTEDCPKSLLIPYLD CCCCCCHHHHHHHHH	17.35	26643407
488	Ubiquitination	YLDNLVKHLHSIMVL HHHHHHHHHHHHHHH	22.69	27667366
518	Phosphorylation	QVVTSIASVADTAEE HHHHHHHHHHHHHHH	19.03	26824392
548	Ubiquitination	IVENAVQKELRLLRG HHHHHHHHHHHHHCC	52.71	22790023
548	Acetylation	IVENAVQKELRLLRG HHHHHHHHHHHHHCC	52.71	22826441
556	Ubiquitination	ELRLLRGKTIECISL HHHHHCCCCHHHHHH	39.64	-
578	Phosphorylation	EKFMQDASDVMQLLL HHHCCCHHHHHHHHH	38.74	20139300
613	Ubiquitination	SAWARMCKILGKEFQ HHHHHHHHHHCHHHH	31.46	-
633	Phosphorylation	VMGPLMKTASIKPEV HHCCHHCCCCCCCCE	16.21	23984901
635	Phosphorylation	GPLMKTASIKPEVAL CCHHCCCCCCCCEEE	36.05	23984901
645	Phosphorylation	PEVALLDTQDMENMS CCEEEECCCCCCCCC	26.83	26239621
652	Phosphorylation	TQDMENMSDDDGWEF CCCCCCCCCCCCCEE	49.85	29514104
667	Phosphorylation	VNLGDQQSFGIKTAG EECCCHHCCCCCCCC	21.58	-
690	Acetylation	QMLVCYAKELKEGFV HHHHHHHHHHHCCHH	36.78	22826441
693	Acetylation	VCYAKELKEGFVEYT HHHHHHHHCCHHHHH	57.81	22826441
733	S-palmitoylation	SMPLLLECARVRGPE HHHHHHHHHHHHCHH	2.71	28526873
733	S-nitrosocysteine	SMPLLLECARVRGPE HHHHHHHHHHHHCHH	2.71	-
733	S-nitrosylation	SMPLLLECARVRGPE HHHHHHHHHHHHCHH	2.71	21278135
740	Ubiquitination	CARVRGPEYLTQMWH HHHHHCHHHHHHHHH	56.87	27667366
743	Phosphorylation	VRGPEYLTQMWHFMC HHCHHHHHHHHHHHH	18.57	29514104
766	Ubiquitination	TEPDSDVLSEIMHSF CCCCHHHHHHHHHHH	4.57	27667366
767	Phosphorylation	EPDSDVLSEIMHSFA CCCHHHHHHHHHHHH	25.56	22807455
800	Ubiquitination	LGGILKAKLEEHFKN HHHHHHHHHHHHHCC	55.64	27667366
820	Phosphorylation	VKRQDEDYDEQVEES HHHCCCCHHHHHHHH	21.23	24224561
826	Ubiquitination	DYDEQVEESLQDEDD CHHHHHHHHHCCCCC	58.87	27667366
827	Phosphorylation	YDEQVEESLQDEDDN HHHHHHHHHCCCCCC	20.16	21082442
972	S-nitrosylation	NVNATENCISAVGKI CCCCCHHHHHHHHHH	1.80	21278135
972	Glutathionylation	NVNATENCISAVGKI CCCCCHHHHHHHHHH	1.80	24333276
972	S-nitrosocysteine	NVNATENCISAVGKI CCCCCHHHHHHHHHH	1.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPO5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPO5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPO5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IPO5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.