TBCD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBCD_MOUSE
• UniProt AC: Q8BYA0
• Protein Name: Tubulin-specific chaperone D
• Gene Name: Tbcd
• Organism: Mus musculus (Mouse).
• Sequence Length: 1196
• Subcellular Localization: Cell junction, tight junction . Lateral cell membrane . Cytoplasm . Cell junction, adherens junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localized in cell-cell contacts.
• Protein Description: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis..
• Protein Sequence: MVLSNEPAASAAEEEVEDDALVRASALEAFGESAETRALLRSLPAVHRERASREVAEERFRVIMDKYQEQPHLLDPHLEWMMNSLLDLVQDETSLPDLVHLAFKFLYIITKVRGYKVFLRLFPHEVANVQPVLDMFTGQNPKDHETWETRYMLLLWLSVTCLIPFDFSRLDGNLSTQTGETRVPTMDRILQIAESYLVVSDKARDAAAVLVSKFITRPDVKQRKMASFLDWSLCTLAHSSFQTIEGVITMDGMLQALAQIFKHGKREDCLPYANTVLQCLDGCRLPESSHTSLRKLGVKLVQRLGLTFLKPKVATWRYQRGCRSLAANLKLCAPGKSDQKLLSDSLTSDGDEDYDVPEGVETVIEQLLVGLKDKDTVVRWSAAKGIGRMAGRLPRELADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLSEVVTVILKALTYDEKRGACSVGANVRDAACYVCWAFARAYEPQELTPFVTAISSALVIAAVFDRNVNCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNISNCFLIISVFIAGFQEYTKPMIDHLVSMKINHWDGAIRELSAKALHNLTPQVPEYIAMHVFPALLLMTQSPDLHTRHGAILACAEVTYALYKLATQSNRLVTDYLDEKAVQSLKQIHQQLCDRHLYRGLGGELMRQAVCILIEKLSLSRMPFKGDATVEGWQWLINDTLRSLHLVSSHSRQQIKEVAVSALTALCSEYYVKEPGEAGSSIAKELIPQYLAELQSPEEMARCGFSSALGALPGFLLRGHLQQVLSGLRRVTCISPNDVSFAEARRDGLKAISRICQTVGVNTRGPPDEVICKENISEVYAALLGCMSDYTTDSRGDVGAWVREAAMTSLMDLMLLLARTEPVLIEAHICERVMCCVAQQASEKIDRFRAHAARVFLTLLHFDSPPIPHVPHRQELESLFPRSDVATVNWNAPSQAFPLITQLLGLPTYRYHVLLGLAVSVGGLTESTVRHSTQSLFEYMKGIQKDAQVLQSFSETLLKVFEDNLLNDRVSVSLLKMLDQLLANGCFDIFTAEENHPFCVKLLTLCKEEIKKSKDIQKLRSSIAVLCGMVQFNGDVRKKILLQLFLLLGHPFPVIRKSTASQVYEMVLTYSDLVDAEVLDEVMSVLSDTAWDAELPVVREQRNRLCDLLGVPRPQLVPKPIPGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVLSNEPAASA ----CCCCCCCCCCC	44.31	25266776
10	Phosphorylation	LSNEPAASAAEEEVE CCCCCCCCCCCHHHC	30.07	27180971
213	Ubiquitination	AAAVLVSKFITRPDV HHHHHHHHHHCCCCH	33.05	-
221	Ubiquitination	FITRPDVKQRKMASF HHCCCCHHHHHHHHH	52.33	-
310	Ubiquitination	RLGLTFLKPKVATWR HHCCCCCCCCHHHHH	38.30	-
321	Ubiquitination	ATWRYQRGCRSLAAN HHHHHHHHHHHHHHH	8.82	27667366
330	Ubiquitination	RSLAANLKLCAPGKS HHHHHHCCCCCCCCC	41.13	-
384	Ubiquitination	VVRWSAAKGIGRMAG CHHHHHHHCHHHHCC	51.26	27667366
656	Phosphorylation	LDEKAVQSLKQIHQQ CCHHHHHHHHHHHHH	30.82	-
701	Phosphorylation	MPFKGDATVEGWQWL CCCCCCCEECHHHHH	24.67	-
862	Phosphorylation	LLGCMSDYTTDSRGD HHHHHCCCCCCCCCC	12.30	-
863	Phosphorylation	LGCMSDYTTDSRGDV HHHHCCCCCCCCCCH	29.17	-
864	Phosphorylation	GCMSDYTTDSRGDVG HHHCCCCCCCCCCHH	26.25	-
866	Phosphorylation	MSDYTTDSRGDVGAW HCCCCCCCCCCHHHH	35.75	-
1013	Ubiquitination	QSLFEYMKGIQKDAQ HHHHHHHHHHHHHHH	52.54	-
1017	Ubiquitination	EYMKGIQKDAQVLQS HHHHHHHHHHHHHHH	53.78	-
1045	Phosphorylation	LNDRVSVSLLKMLDQ CCCHHHHHHHHHHHH	22.07	24759943
1143	Phosphorylation	YEMVLTYSDLVDAEV HHHHHCHHHHCCHHH	21.16	-
1156	Phosphorylation	EVLDEVMSVLSDTAW HHHHHHHHHHCCCCC	25.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBCD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBCD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBCD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TBCD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.