SYWC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYWC_MOUSE
• UniProt AC: P32921
• Protein Name: Tryptophan--tRNA ligase, cytoplasmic
• Gene Name: Wars
• Organism: Mus musculus (Mouse).
• Sequence Length: 481
• Subcellular Localization: Cytoplasm.
• Protein Description: T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity)..
• Protein Sequence: MADMPSGESCTSPLELFNSIATQGELVRSLKAGNAPKDEIDSAVKMLLSLKMSYKAAMGEEYKAGCPPGNPTAGRNCDSDATKASEDFVDPWTVRTSSAKGIDYDKLIVQFGSSKIDKELINRIERATGQRPHRFLRRGIFFSHRDMNQILDAYENKKPFYLYTGRGPSSEAMHLGHLVPFIFTKWLQDVFNVPLVIQMSDDEKYLWKDLTLEQAYSYTVENAKDIIACGFDINKTFIFSDLEYMGQSPGFYRNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAVQAAPSFSNSFPKIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGHPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKSKVNKHAFSGGRDTVEEHRQFGGNCEVDVSFMYLTFFLEDDDRLEQIRKDYTSGAMLTGELKKTLIDVLQPLIAEHQARRKAVTEETVKEFMTPRQLSFHFQCFCFDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MADMPSGESCTSP --CCCCCCCCCCCCH	48.86	26745281
9	Phosphorylation	ADMPSGESCTSPLEL CCCCCCCCCCCHHHH	26.64	26745281
11	Phosphorylation	MPSGESCTSPLELFN CCCCCCCCCHHHHHH	42.53	26745281
12	Phosphorylation	PSGESCTSPLELFNS CCCCCCCCHHHHHHH	31.64	26745281
19	Phosphorylation	SPLELFNSIATQGEL CHHHHHHHHCCHHHH	13.28	26745281
31	Malonylation	GELVRSLKAGNAPKD HHHHHHHHCCCCCHH	56.33	26320211
63	Acetylation	AAMGEEYKAGCPPGN HHCCCHHHCCCCCCC	41.40	22826441
66	S-nitrosocysteine	GEEYKAGCPPGNPTA CCHHHCCCCCCCCCC	4.37	-
66	S-nitrosylation	GEEYKAGCPPGNPTA CCHHHCCCCCCCCCC	4.37	21278135
66	Glutathionylation	GEEYKAGCPPGNPTA CCHHHCCCCCCCCCC	4.37	24333276
98	Phosphorylation	PWTVRTSSAKGIDYD CCCEECCCCCCCCHH	33.13	25338131
106	Ubiquitination	AKGIDYDKLIVQFGS CCCCCHHHEEEECCC	33.61	22790023
158	Acetylation	LDAYENKKPFYLYTG HHHHHCCCCEEEEEC	52.52	23806337
158	Succinylation	LDAYENKKPFYLYTG HHHHHCCCCEEEEEC	52.52	23806337
158	Ubiquitination	LDAYENKKPFYLYTG HHHHHCCCCEEEEEC	52.52	-
158	Succinylation	LDAYENKKPFYLYTG HHHHHCCCCEEEEEC	52.52	-
260	Acetylation	RNVVKIQKHVTFNQV HHHHHEEECCCHHHC	43.44	22826441
278	Glutathionylation	FGFTDSDCIGKISFP CCCCCHHHEEEECCH	5.24	24333276
320	Phosphorylation	CAIDQDPYFRMTRDV ECCCCCCCCCCCCCC	16.47	-
355	Phosphorylation	QGAQTKMSASDPNSS CCCCCCCCCCCCCCC	26.61	28066266
357	Phosphorylation	AQTKMSASDPNSSIF CCCCCCCCCCCCCEE	46.42	28066266
370	Ubiquitination	IFLTDTAKQIKSKVN EEEECHHHHHHHHHH	55.43	-
370	Malonylation	IFLTDTAKQIKSKVN EEEECHHHHHHHHHH	55.43	26320211
370	Acetylation	IFLTDTAKQIKSKVN EEEECHHHHHHHHHH	55.43	23954790
378	Malonylation	QIKSKVNKHAFSGGR HHHHHHHHHHCCCCC	39.02	26320211
436	Ubiquitination	MLTGELKKTLIDVLQ HHCHHHHHHHHHHHH	62.28	22790023
454	Ubiquitination	AEHQARRKAVTEETV HHHHHHHHCCCHHHH	41.47	22790023
457	Phosphorylation	QARRKAVTEETVKEF HHHHHCCCHHHHHHH	32.72	20469934
460	Phosphorylation	RKAVTEETVKEFMTP HHCCCHHHHHHHCCH	30.55	20469934
466	Phosphorylation	ETVKEFMTPRQLSFH HHHHHHCCHHHEEEE	22.20	20469934
471 (in isoform 2)	Phosphorylation	-	14.34	27841257
471	Phosphorylation	FMTPRQLSFHFQCFC HCCHHHEEEEEEEEE	14.34	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYWC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYWC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYWC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYWC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.