dbPTM

NAA40_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NAA40_MOUSE
UniProt AC	Q8VE10
Protein Name	N-alpha-acetyltransferase 40 {ECO:0000312\|MGI:MGI:1918249}
Gene Name	Naa40 {ECO:0000312\|MGI:MGI:1918249}
Organism	Mus musculus (Mouse).
Sequence Length	237
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (By similarity). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (By similarity). Acts as a negative regulator of apoptosis (By similarity). May play a role in hepatic lipid metabolism. [PubMed: 22231784]
Protein Sequence	MGRKSSKAKEKKQKRLEERAAMDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGLEPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSIPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSRRTKFGDSQHSHTGGHCGGCCH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGRKSSKAK ------CCCCCHHHH	45.80	-
26	Glutathionylation	RAAMDAVCAKVDAAN HHHHHHHHHHHHHHH	3.04	24333276
63	Phosphorylation	SIECKRVSGLEPATV EEEEEECCCCCCEEC	41.51	26745281
69	Phosphorylation	VSGLEPATVDWAFDL CCCCCCEECEEEEEC	29.70	26745281
183	Phosphorylation	FKHNHGAYQFFREAL HHCCCHHHHHHHHHH	15.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NAA40_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NAA40_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NAA40_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NAA40_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NAA40_MOUSE

Related Literatures of Post-Translational Modification