CLU_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLU_MOUSE
• UniProt AC: Q5SW19
• Protein Name: Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013}
• Gene Name: Cluh
• Organism: Mus musculus (Mouse).
• Sequence Length: 1315
• Subcellular Localization: Cytoplasm . Cytoplasmic granule .
• Protein Description: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis..
• Protein Sequence: MLLNGDCSENLKKEEGTSEPPRENGLDEGEPGDETTGQEVIVIQDTGFSVKILAPGIEPFSLQVSPQEMVQEIHQVLMDREDTCHRTCFSLHLDGNMLDHFSELRSVEGLQEGSVLRVVEEPYTVREARIHVRHVRDLLKSLDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKRKKGLEMDPIDCTPPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMYLFVITAEDRQVSITASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELLNQISPTFKKNFAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQTRDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPLKILRHRVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPEECSRAGFPRTHRHKLCCLRQELVDAFVEHRYLLFMKLAALQLMQQKASKVETTTSLENGGLPSSAETKSEDSIGPEAGCEEEGSSVSGLAKVKELAETIASDDGTVDPRSREVIRNACKAVGSISSTAFDIRFNPDIFSPGVRFPESCQDEVRDQKQLLKDAAAFLLSCQIPGLVKDCTEYAVLPMDGATLAEVMRQRGINMRYLGKVLDLVLRSPARDQLDHIYKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYPNPVAHLPADELLSKKRNKRRKNRPPGAADNTAWAVMTPQELWKNICHEAKNYFDFTLECDSVDQAVETYGLQKITLLREISLKTGIQILLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGIEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVTTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQAVALQRTMNEIYRNGSSANIPPLKFTAPSMTSVLEQLNVINGILFIPLSQKDLENLKAEVARRHQLQEANRNRDKAEEQPMAPEPEPEPERAVEDMGSPQTAKEGPSSLNLQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Ubiquitination	GDSGKRKKGLEMDPI CCCCCCCCCCCCCCC		22790023
210	Ubiquitination	QPQNRDWKPLQCLKV CCCCCCCCCHHHEEE		22790023
279	Phosphorylation	PASPRFLSHSLVELL CCCCHHHHHHHHHHH		-
281	Phosphorylation	SPRFLSHSLVELLNQ CCHHHHHHHHHHHHH		-
295	Ubiquitination	QISPTFKKNFAVLQK HHCHHHHHCHHHHHH		22790023
437	Ubiquitination	FDVRDHYKDFGGDVA CCHHHHHHHHCCCEE		22790023
509	Ubiquitination	YGSIDFGKTVVSHPR EEEEECCCCHHCCHH		22790023
517	Phosphorylation	TVVSHPRYLELLERT CHHCCHHHHHHHHHC		19854140
524	Phosphorylation	YLELLERTSRPLKIL HHHHHHHCCCCHHHH		19854140
525	Phosphorylation	LELLERTSRPLKILR HHHHHHCCCCHHHHH		19854140
529	Ubiquitination	ERTSRPLKILRHRVL HHCCCCHHHHHHHHH		22790023
632	Ubiquitination	ALQLMQQKASKVETT HHHHHHHHHHCCCCC		22790023
635	Ubiquitination	LMQQKASKVETTTSL HHHHHHHCCCCCCCH		22790023
641	Phosphorylation	SKVETTTSLENGGLP HCCCCCCCHHCCCCC		30352176
650	Phosphorylation	ENGGLPSSAETKSED HCCCCCCCCCCCCCC		27742792
655	Phosphorylation	PSSAETKSEDSIGPE CCCCCCCCCCCCCCC		25521595
658	Phosphorylation	AETKSEDSIGPEAGC CCCCCCCCCCCCCCC		25521595
665	S-nitrosocysteine	SIGPEAGCEEEGSSV CCCCCCCCCCCCCCC		-
671	Phosphorylation	GCEEEGSSVSGLAKV CCCCCCCCCCHHHHH		25521595
677	Ubiquitination	SSVSGLAKVKELAET CCCCHHHHHHHHHHH		22790023
679	Ubiquitination	VSGLAKVKELAETIA CCHHHHHHHHHHHHH		22790023
684	Phosphorylation	KVKELAETIASDDGT HHHHHHHHHHCCCCC		29899451
687	Phosphorylation	ELAETIASDDGTVDP HHHHHHHCCCCCCCH		25521595
705	Acetylation	EVIRNACKAVGSISS HHHHHHHHHHCCCCC		15624039
725	Phosphorylation	RFNPDIFSPGVRFPE ECCCCCCCCCCCCCH		-
734	S-nitrosocysteine	GVRFPESCQDEVRDQ CCCCCHHHHHHHHHH		-
755	S-palmitoylation	AAAFLLSCQIPGLVK HHHHHHHCCCCCHHC		28526873
793	Ubiquitination	INMRYLGKVLDLVLR CCHHHHHHHHHHHHC		22790023
812	Ubiquitination	DQLDHIYKIGIGELI HHCHHHHHHCHHHHH		22790023
876	Ubiquitination	KKRNKRRKNRPPGAA HHHHHHHCCCCCCCC		22790023
930	Phosphorylation	TYGLQKITLLREISL HHCCCHHHHHHHHHH		26239621
936	Phosphorylation	ITLLREISLKTGIQI HHHHHHHHHHHCHHH		26239621
955	Ubiquitination	YSFDSRHKPAFTEED CCCCCCCCCCCCHHH		22790023
976	Ubiquitination	VVKHVNPKASDAFHF HCCCCCCCCHHHHHH		22790023
990	Ubiquitination	FFQSGQAKVQQGFLK HHHHCCHHHHHCHHH		22790023
1172	Ubiquitination	RSALQHEKEGYTIYK HHHHHHHHCCCEEEE		22790023
1172	Malonylation	RSALQHEKEGYTIYK HHHHHHHHCCCEEEE		32601280
1172	Acetylation	RSALQHEKEGYTIYK HHHHHHHHCCCEEEE		23954790
1197	Ubiquitination	KESSEYLKCLTQQAV HHHHHHHHHHHHHHH		22790023
1198	S-nitrosocysteine	ESSEYLKCLTQQAVA HHHHHHHHHHHHHHH		-
1218	Phosphorylation	NEIYRNGSSANIPPL HHHHHCCCCCCCCCC		25521595
1219	Phosphorylation	EIYRNGSSANIPPLK HHHHCCCCCCCCCCC		18846507
1259	Ubiquitination	QKDLENLKAEVARRH HHHHHHHHHHHHHHH		22790023
1300	Phosphorylation	RAVEDMGSPQTAKEG HHHCCCCCCCCCCCC		25521595
1303	Phosphorylation	EDMGSPQTAKEGPSS CCCCCCCCCCCCCCC		27149854
1309	Phosphorylation	QTAKEGPSSLNLQG- CCCCCCCCCCCCCC-		26643407
1310	Phosphorylation	TAKEGPSSLNLQG-- CCCCCCCCCCCCC--		25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLU_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLU_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLU_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CLU_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.