dbPTM

LTOR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LTOR1_MOUSE
UniProt AC	Q9CQ22
Protein Name	Ragulator complex protein LAMTOR1
Gene Name	Lamtor1
Organism	Mus musculus (Mouse).
Sequence Length	161
Subcellular Localization	Late endosome membrane Lipid-anchor Cytoplasmic side. Lysosome membrane Lipid-anchor Cytoplasmic side. Cell membrane Lipid-anchor .
Protein Description	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation..
Protein Sequence	MGCCYSSENEDSDQDREERKLLLDPSSTPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCCYSSEN ------CCCCCCCCC	15.37	-
20	Ubiquitination	DQDREERKLLLDPSS CCCHHHHHHHCCCCC	46.93	22790023
26	Phosphorylation	RKLLLDPSSTPTKAL HHHHCCCCCCCCHHH	46.65	24925903
27	Phosphorylation	KLLLDPSSTPTKALN HHHCCCCCCCCHHHC	43.74	24925903
28	Phosphorylation	LLLDPSSTPTKALNG HHCCCCCCCCHHHCC	39.04	24925903
30	Phosphorylation	LDPSSTPTKALNGAE CCCCCCCCHHHCCCC	29.10	24925903
31	Ubiquitination	DPSSTPTKALNGAEP CCCCCCCHHHCCCCC	52.67	22790023
40	Phosphorylation	LNGAEPNYHSLPSAR HCCCCCCCCCCCCCC	11.96	25159016
42	Phosphorylation	GAEPNYHSLPSARTD CCCCCCCCCCCCCCH	31.45	30635358
45	Phosphorylation	PNYHSLPSARTDEQA CCCCCCCCCCCHHHH	35.36	30635358
48	Phosphorylation	HSLPSARTDEQALLS CCCCCCCCHHHHHHH	43.54	27717184
55	Phosphorylation	TDEQALLSSILAKTA CHHHHHHHHHHHHHH	19.04	26239621
56	Phosphorylation	DEQALLSSILAKTAS HHHHHHHHHHHHHHH	22.91	26824392
61	Phosphorylation	LSSILAKTASNIIDV HHHHHHHHHHCCCCH	29.70	27742792
63	Phosphorylation	SILAKTASNIIDVSA HHHHHHHHCCCCHHH	33.52	25521595
69	Phosphorylation	ASNIIDVSAADSQGM HHCCCCHHHHHHCCC	17.62	-
73	Phosphorylation	IDVSAADSQGMEQHE CCHHHHHHCCCHHHH	24.73	-
96	Phosphorylation	STRLAVLSSSLTHWK HHHHHHHHHCCCCHH	15.98	26745281
97	Phosphorylation	TRLAVLSSSLTHWKK HHHHHHHHCCCCHHH	25.80	26745281
98	Phosphorylation	RLAVLSSSLTHWKKL HHHHHHHCCCCHHHC	33.63	26745281
100	Phosphorylation	AVLSSSLTHWKKLPP HHHHHCCCCHHHCCC	27.86	26745281
104	Ubiquitination	SSLTHWKKLPPLPSL HCCCCHHHCCCCCCC	62.12	27667366
110	Phosphorylation	KKLPPLPSLTSQPHQ HHCCCCCCCCCCCCE	52.54	26060331
112	Phosphorylation	LPPLPSLTSQPHQVL CCCCCCCCCCCCEEH	29.65	26060331
113	Phosphorylation	PPLPSLTSQPHQVLA CCCCCCCCCCCEEHH	47.19	24719451
138	Phosphorylation	QVSRIAAYAYSALSQ HHHHHHHHHHHHHHC	9.32	-
140	Phosphorylation	SRIAAYAYSALSQIR HHHHHHHHHHHHCCC	5.04	-
141	Phosphorylation	RIAAYAYSALSQIRV HHHHHHHHHHHCCCC	17.98	27180971
144	Phosphorylation	AYAYSALSQIRVDAK HHHHHHHHCCCCCCC	24.23	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LTOR1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LTOR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LTOR1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LTOR1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LTOR1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-28, AND MASSSPECTROMETRY.	15345747 [Abstract]