XPO2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPO2_MOUSE
• UniProt AC: Q9ERK4
• Protein Name: Exportin-2
• Gene Name: Cse1l
• Organism: Mus musculus (Mouse).
• Sequence Length: 971
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm.
• Protein Description: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus..
• Protein Sequence: MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGREVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSNNVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLISHLEAESIVVHTYAAHALERLFTMRGSNNTTLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSSTIATAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDSIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MELSDANL -------CCCCHHHH	12.03	-
18	Phosphorylation	LTEYLKKTLDPDPAI HHHHHHHHCCCCHHH	34.50	-
112	Phosphorylation	EQIQKQLSDAISIIG HHHHHHHHHHHHHHC	23.62	22817900
191	Phosphorylation	LTNLFKATIELCSTH HHHHHHHHHHHHHCC	18.64	23649490
203	Phosphorylation	STHANDASALRILFS HCCCCCHHHHHHHHH	30.60	23649490
255	Phosphorylation	LDNKLLQTDDEEEAG HCCCCCCCCCHHHHH	45.44	26525534
377	Phosphorylation	IRRDLEGSDIDTRRR HHHHCCCCCHHHHHH	23.24	26525534
427	Acetylation	PSVNWKHKDAAIYLV CCCCCCHHHHHHHHH	45.39	6569383
574	Acetylation	SENEYIMKAIMRSFS CHHHHHHHHHHHHHH	25.79	23236377
579	Phosphorylation	IMKAIMRSFSLLQEA HHHHHHHHHHHHHHH	11.21	25777480
581	Phosphorylation	KAIMRSFSLLQEAII HHHHHHHHHHHHHHH	29.44	25777480
590	Phosphorylation	LQEAIIPYIPTLITQ HHHHHHHHHHHHHHH	14.77	25777480
593	Phosphorylation	AIIPYIPTLITQLTQ HHHHHHHHHHHHHHH	22.64	25777480
596	Phosphorylation	PYIPTLITQLTQKLL HHHHHHHHHHHHHHH	22.19	25777480
599	Phosphorylation	PTLITQLTQKLLAVS HHHHHHHHHHHHHHC	17.53	25777480
824	Acetylation	MFGMVLEKIIIPEIQ HHHHHHHHHHHHHHH	34.74	-
832	Acetylation	IIIPEIQKVSGNVEK HHHHHHHHCCCCCCH	43.99	23236377
842	Glutathionylation	GNVEKKICAVGITKL CCCCHHHHHHHHHHH	3.26	24333276
931	Phosphorylation	PKIHLAQSLHKLSTA CHHHHHHHHHHHHCC	27.17	24719451
939	S-nitrosocysteine	LHKLSTACPGRVPSM HHHHHCCCCCCCCHH	3.58	-
939	S-nitrosylation	LHKLSTACPGRVPSM HHHHHCCCCCCCCHH	3.58	20925432

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XPO2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPO2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPO2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of XPO2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.