ILF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ILF2_MOUSE
• UniProt AC: Q9CXY6
• Protein Name: Interleukin enhancer-binding factor 2
• Gene Name: Ilf2
• Organism: Mus musculus (Mouse).
• Sequence Length: 390
• Subcellular Localization: Nucleus, nucleolus . Cytoplasm. Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs..
• Protein Description: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity)..
• Protein Sequence: MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Asymmetric dimethylarginine	RGGRFGSRGGPGGGF CCCCCCCCCCCCCCC	55.24	-
16	Methylation	RGGRFGSRGGPGGGF CCCCCCCCCCCCCCC	55.24	24129315
24	Methylation	GGPGGGFRPFVPHIP CCCCCCCCCCCCCCC	27.33	24129315
37	S-nitrosocysteine	IPFDFYLCEMAFPRV CCCCEEEEHHHCCCC	1.98	-
37	S-nitrosylation	IPFDFYLCEMAFPRV CCCCEEEEHHHCCCC	1.98	20925432
45	Ubiquitination	EMAFPRVKPAPDETS HHHCCCCCCCCCCCC	36.42	-
51	Phosphorylation	VKPAPDETSFSEALL CCCCCCCCCHHHHHH	42.31	26643407
52	Phosphorylation	KPAPDETSFSEALLK CCCCCCCCHHHHHHH	25.40	26824392
54	Phosphorylation	APDETSFSEALLKRN CCCCCCHHHHHHHHC	23.02	26643407
68	Phosphorylation	NQDLAPNSAEQASIL CCCCCCCHHHHHHHH	31.93	25293948
73	Phosphorylation	PNSAEQASILSLVTK CCHHHHHHHHHHHHH	24.61	25293948
218	Phosphorylation	FEENASQSTVKVLIR HHHCCCHHHHHHHHH	32.45	25338131
385	Phosphorylation	PQGEEEESMETQE-- CCCCHHHHHCCCC--	25.79	26370283
388	Phosphorylation	EEEESMETQE----- CHHHHHCCCC-----	29.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ILF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ILF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ILF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ILF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.