GNL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNL3_MOUSE
• UniProt AC: Q8CI11
• Protein Name: Guanine nucleotide-binding protein-like 3
• Gene Name: Gnl3
• Organism: Mus musculus (Mouse).
• Sequence Length: 538
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Shuttles between the nucleus and nucleolus.
• Protein Description: May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation..
• Protein Sequence: MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEALLREAELRKQQLEELKQQQKLDRQKEQERKRKLEVSPGDEQSNVETREESDEPKRKKAKAGKQNPKKLHCQELKKVIEASDIVLEVLDARDPLGCRCPQIEEAVIQSGSKKLILVLNKSDLVPKENLENWLNYLNKELPTVVFKASTNLKNRKTFKIKKKKVVPFQSKICCGKEALWKLLGDFQQSCGKDIQVGVIGFPNVGKSSVINSLKQEWICNVGISMGLTRSMQIVPLDKQITIIDSPCLIISPCNSPTALALRSPASIEELRPLEAASAILSQADNEQVVLKYTVPEYKDSLHFFTKLAQRRGLHQKGGSPNVESAAKLVWSEWTGASLGYYCHPPASWNHSLHFNENIAAVMKKGFNLEELEKNNAHSIQVLKGPHLTNRILFRSSGLTNGILDEKDIVEESPRQTEDKQDADDQENGSGERNAEISDVAPVEETRELSPEQSTAGKPSDGSSALDRASQEDETYDFTTDYI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Acetylation	EELKQQQKLDRQKEQ HHHHHHHHHHHHHHH	48.28	-
95	Phosphorylation	RKRKLEVSPGDEQSN HHHHCCCCCCCHHCC	17.50	27087446
101	Phosphorylation	VSPGDEQSNVETREE CCCCCHHCCCCCCCC	40.57	25619855
105	Phosphorylation	DEQSNVETREESDEP CHHCCCCCCCCCCCH	38.81	25619855
109	Phosphorylation	NVETREESDEPKRKK CCCCCCCCCCHHHHH	42.39	25777480
362	Acetylation	DSLHFFTKLAQRRGL HHHHHHHHHHHHCCC	36.35	22826441
375	Phosphorylation	GLHQKGGSPNVESAA CCHHCCCCCCHHHHH	23.21	25159016
380	Phosphorylation	GGSPNVESAAKLVWS CCCCCHHHHHHHHHH	29.28	25159016
468	Phosphorylation	EKDIVEESPRQTEDK HHHHHCCCCCCCCCC	16.33	27087446
472 (in isoform 2)	Phosphorylation	-	47.64	19144319
472	Phosphorylation	VEESPRQTEDKQDAD HCCCCCCCCCCCCCC	47.64	26643407
485	Phosphorylation	ADDQENGSGERNAEI CCCCCCCCCCCCCCC	49.41	23684622
493	Phosphorylation	GERNAEISDVAPVEE CCCCCCCCCCCCHHH	19.96	22942356
501	Phosphorylation	DVAPVEETRELSPEQ CCCCHHHHHCCCCCC	18.88	26824392
505	Phosphorylation	VEETRELSPEQSTAG HHHHHCCCCCCCCCC	22.95	27087446
509	Phosphorylation	RELSPEQSTAGKPSD HCCCCCCCCCCCCCC	20.68	27742792
510	Phosphorylation	ELSPEQSTAGKPSDG CCCCCCCCCCCCCCC	38.84	22942356
515	Phosphorylation	QSTAGKPSDGSSALD CCCCCCCCCCCCHHH	59.08	25619855
518	Phosphorylation	AGKPSDGSSALDRAS CCCCCCCCCHHHHHH	19.89	25619855
519	Phosphorylation	GKPSDGSSALDRASQ CCCCCCCCHHHHHHC	38.08	25619855
530	Phosphorylation	RASQEDETYDFTTDY HHHCCCCCCCCCCCC	40.49	25619855
531	Phosphorylation	ASQEDETYDFTTDYI HHCCCCCCCCCCCCC	13.65	25619855
535	Phosphorylation	DETYDFTTDYI---- CCCCCCCCCCC----	27.14	24453211
537	Phosphorylation	TYDFTTDYI------ CCCCCCCCC------	13.36	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNL3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GNL3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, AND MASSSPECTROMETRY.
PubMed: 19144319