SMC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMC2_MOUSE
• UniProt AC: Q8CG48
• Protein Name: Structural maintenance of chromosomes protein 2
• Gene Name: Smc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1191
• Subcellular Localization: Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromos
• Protein Description: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)..
• Protein Sequence: MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLRAEDTKERSAGELKEMQDKIVNLQEVLSENEKKIKALNCEIEELERRKDKETGGKLKSLEDACAEAQRVNTKSQSAFDLKKKNLASEETKRKELQNSMAEDSKALAAKEKEVKKITDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMIACKNDISKAQTEAKQAQMKLKHAQQELKSKQAEVKKMDSGYKKDQDAFEAVKKAKEKLETEMKKLNYEENKEEKLLEKHRQLSRDINNLKGKHEALLAKFPNLQFAYKDPEKNWNRNSVKGLVASLINVKDNSTATALEVVAGERLYNVVVDTEVTAKKLLEKGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVDYKPELQKGMEFVFGTTFVCNNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQEVKDVQDELRTKENELRALEEELAGLKNVAEKYRQLKQQWEMKTEEGDLLQTKLQQSSYHKQQEELDALKKTIEESEETLKSTKEIQKKAEEKYEALENKMKNAEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHASNEQQLDAVNEAIKAYEGQIEKMAAEVAKNKESVNKAQDELMKQKQIITAQDNIIKDKCAEVAKHNLQNNESQLKIKELDHSISKHKREADDAAAKVSKMLSDYDWINAEKHLFGQPNSAYDFKTNNPKEAGQRLQKLQEVKEKLGRNVNLRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQSQAGKIPKEAKSRGKEPN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	NLSQVRASNLQDLVY CHHHHHHHCHHHHHH	27.75	28066266
114	Acetylation	VVIGGRNKYLINGVN EEECCCCCEEEECCC	39.82	-
196	Acetylation	EAKLKEIKTILEEEI HHHHHHHHHHHHHCC	30.51	2390535
209	Acetylation	EITPTIQKLKEERSS CCCHHHHHHHHHHHH	58.64	2390543
211	Acetylation	TPTIQKLKEERSSYL CHHHHHHHHHHHHHH	65.64	2390551
222	Acetylation	SSYLEYQKVMREIEH HHHHHHHHHHHHHHH	36.78	-
237	Phosphorylation	LSRLYIAYQFLRAED HHHHHHHHHHHCCHH	7.11	-
303	Glutathionylation	LKSLEDACAEAQRVN CCCHHHHHHHHHHHC	5.63	24333276
320	Acetylation	SQSAFDLKKKNLASE CCCHHHHHHHCCCCH	64.64	7379913
337	Phosphorylation	KRKELQNSMAEDSKA HHHHHHHHHHHHHHH	13.35	23737553
342	Phosphorylation	QNSMAEDSKALAAKE HHHHHHHHHHHHHHH	16.01	23737553
455	Acetylation	QDAFEAVKKAKEKLE HHHHHHHHHHHHHHH	54.80	7614413
456	Acetylation	DAFEAVKKAKEKLET HHHHHHHHHHHHHHH	59.08	19854385
474	Ubiquitination	KLNYEENKEEKLLEK HCCHHHHHHHHHHHH	71.21	-
477	Ubiquitination	YEENKEEKLLEKHRQ HHHHHHHHHHHHHHH	60.51	-
486	Phosphorylation	LEKHRQLSRDINNLK HHHHHHHHHHHHHCC	21.40	26060331
515	Acetylation	FAYKDPEKNWNRNSV EEECCCCCCCCHHCH	73.06	23806337
574	Phosphorylation	GELKRRYTIIPLNKI CCCCCEEEEEEHHHH	15.60	-
651	Phosphorylation	RIMTRTVTLGGDVFD CCCCCEEEECCCEEC	21.05	29514104
677	Acetylation	QAASILTKFQEVKDV HHHHHHHHHHHHHHH	41.42	22826441
773	Phosphorylation	QKKAEEKYEALENKM HHHHHHHHHHHHHHH	15.09	21189417
808	Phosphorylation	AKTKADASSKKMKEK HHHHHHHHHHHHHHH	43.15	22418434
809	Phosphorylation	KTKADASSKKMKEKQ HHHHHHHHHHHHHHH	37.71	22418434
850	Phosphorylation	VNEAIKAYEGQIEKM HHHHHHHHHHHHHHH	18.65	29895711
856	Acetylation	AYEGQIEKMAAEVAK HHHHHHHHHHHHHHH	35.15	22826441
916	Phosphorylation	KIKELDHSISKHKRE HHHHHHHHHHHHHHH	28.37	28066266
918	Phosphorylation	KELDHSISKHKREAD HHHHHHHHHHHHHHH	31.55	28066266
1158	Acetylation	NNANVLFKTKFVDGV CCCCEEEEEEECCCC	46.79	23236377
1160	Acetylation	ANVLFKTKFVDGVST CCEEEEEEECCCCHH	43.94	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SMC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.