VPS53_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS53_MOUSE
• UniProt AC: Q8CCB4
• Protein Name: Vacuolar protein sorting-associated protein 53 homolog
• Gene Name: Vps53
• Organism: Mus musculus (Mouse).
• Sequence Length: 832
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Recycling endosome . Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling end
• Protein Description: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane..
• Protein Sequence: MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDQADFNAVEYINTLFPTEQSLANIDDVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWVKRQLVDYEEKYGRMFPREWCMTERISVEFCHVTRAELSKIMRARAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDETTPEMEELALEKGELEQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLSELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTSSSSGGLTISSLLKEKEGSEVARFTLEELCLICSILSTAEYCLATTQQLEEKLKEKVDVSLTERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALIAMSKMPWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCIKFANSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSIGSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNSETFQKILDMKGLKRSEQSSMLELLRQRLPAPPSGTEGSSTLSLIAPTPEQESSRIRKLEKLIKKRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Acetylation	AIQQLFGKIKDIKDK HHHHHHHHHHHHHHH	38.97	23236377
143	Phosphorylation	DHAKRHLTTSITTLN HHHHHHHHHHHHHHH	16.63	-
161	Phosphorylation	MLAGGVDSLEAMTRR HHHCCCCHHHHHHHH	26.21	-
253	Acetylation	NILDPRIKQEIIKKF HCCCHHHHHHHHHHH	43.06	23201123
360	Acetylation	NFEGFLAKRFSGCTL CCCCHHHHHCCCCEE	57.00	-
377	Phosphorylation	GTLKKLESPPPSTNP CCCCCCCCCCCCCCC	53.82	25521595
381	Phosphorylation	KLESPPPSTNPFLED CCCCCCCCCCCCCCC	46.74	25521595
382	Phosphorylation	LESPPPSTNPFLEDE CCCCCCCCCCCCCCC	53.32	24925903
390	Phosphorylation	NPFLEDETTPEMEEL CCCCCCCCCHHHHHH	61.03	29899451
391	Phosphorylation	PFLEDETTPEMEELA CCCCCCCCHHHHHHH	18.40	25521595
580	Phosphorylation	LKEKVDVSLTERINL HHHHCCCCHHHCCCC	25.72	-
734	Phosphorylation	KIVVKGMTRAEMILK EEEEECCCHHHHHHH	35.08	28576409
784	Phosphorylation	GLKRSEQSSMLELLR CCCHHHHHHHHHHHH	17.42	29895711
785	Phosphorylation	LKRSEQSSMLELLRQ CCHHHHHHHHHHHHH	27.38	29895711
826	Malonylation	SRIRKLEKLIKKRL- HHHHHHHHHHHHHC-	66.98	26073543

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS53_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS53_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS53_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VPS53_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.