R3GEF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: R3GEF_MOUSE
• UniProt AC: Q8VDV3
• Protein Name: Guanine nucleotide exchange factor for Rab-3A
• Gene Name: Rab3il1
• Organism: Mus musculus (Mouse).
• Sequence Length: 383
• Protein Description: Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activates RAB8A and RAB8B (By similarity)..
• Protein Sequence: MWSGQPQQDEGLPVGLSAIPVPWKNLGPSKSNRESSGGLVEASTSWEEAQGEEHPAPAPLDVSRLRSSSMEIREKGSEFLKEELYKAQKELKLKDEECERLCKVRAQLEQELEELTASLFEEAHKMVREANMKQATSEKQLKEAWGKIDMLQAEVTALKTLVITSTPASPNRELHPQLLSPTKAGPRKGHSRQKSTSSSLCPVVCPTAGHIPTPDKEGKEVDTTLFAEFQAWRASPTLDKSCPFLERVYREDVGPCLDFTVQELSALVRTAVEDNTLTIEPVASQTLPAVKVPTVECNNTNTCALSGLARTCHHRIRLGDSDSHYYISPSSRARITAVCNFFTYIRYIQQGLVRQDAEPMFWEIMRLRKGMSLAKLGFFPQEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	SGGLVEASTSWEEAQ CCCCEEECCCHHHHC	14.96	30635358
44	Phosphorylation	GGLVEASTSWEEAQG CCCEEECCCHHHHCC	44.93	30635358
45	Phosphorylation	GLVEASTSWEEAQGE CCEEECCCHHHHCCC	29.96	19060867
67	Phosphorylation	LDVSRLRSSSMEIRE CCHHHHHHCCHHHHH	31.21	23737553
68	Phosphorylation	DVSRLRSSSMEIREK CHHHHHHCCHHHHHH	27.54	23737553
69	Phosphorylation	VSRLRSSSMEIREKG HHHHHHCCHHHHHHH	22.98	26824392
85	Phosphorylation	EFLKEELYKAQKELK HHHHHHHHHHHHHHC	13.93	25367039
133	Acetylation	MVREANMKQATSEKQ HHHHHHHHHCCCHHH	36.27	6568249
160	Phosphorylation	AEVTALKTLVITSTP HHHHHEEEEEEECCC	27.40	20531401
164	Phosphorylation	ALKTLVITSTPASPN HEEEEEEECCCCCCC	21.04	26643407
165	Phosphorylation	LKTLVITSTPASPNR EEEEEEECCCCCCCC	22.67	22942356
166	Phosphorylation	KTLVITSTPASPNRE EEEEEECCCCCCCCC	17.77	22942356
169	Phosphorylation	VITSTPASPNRELHP EEECCCCCCCCCCCH	24.74	22942356
180	Phosphorylation	ELHPQLLSPTKAGPR CCCHHHCCCCCCCCC	38.83	25521595
182	Phosphorylation	HPQLLSPTKAGPRKG CHHHCCCCCCCCCCC	30.10	30635358
195	Phosphorylation	KGHSRQKSTSSSLCP CCCCCCCCCCCCCCC	25.78	25521595
196	Phosphorylation	GHSRQKSTSSSLCPV CCCCCCCCCCCCCCE	39.40	25521595
197	Phosphorylation	HSRQKSTSSSLCPVV CCCCCCCCCCCCCEE	25.64	26643407
198	Phosphorylation	SRQKSTSSSLCPVVC CCCCCCCCCCCCEEC	27.67	26643407
199	Phosphorylation	RQKSTSSSLCPVVCP CCCCCCCCCCCEECC	33.48	25521595
207	Phosphorylation	LCPVVCPTAGHIPTP CCCEECCCCCCCCCC	39.89	26643407
328	Phosphorylation	SDSHYYISPSSRARI CCCCEEECCHHHHHH	11.56	23684622
330	Phosphorylation	SHYYISPSSRARITA CCEEECCHHHHHHHH	26.18	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
169	S	Phosphorylation	Kinase	CDK5	P49615	PSP
180	S	Phosphorylation	Kinase	CDK5	P49615	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of R3GEF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of R3GEF_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of R3GEF_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.