ANFY1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANFY1_MOUSE
• UniProt AC: Q810B6
• Protein Name: Rabankyrin-5 {ECO:0000303|PubMed:15328530}
• Gene Name: Ankfy1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1169
• Subcellular Localization: Cytoplasm . Endosome membrane ; Peripheral membrane protein . Cytoplasmic vesicle . Also associated with endosomal membranes. Localizes to macropinosomes. In kidney proximal tubule cells localizes to vesicle-like structures underneath the apical brus
• Protein Description: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity). Involved in macropinocytosis; the function is dependent on Rab5-GTP..
• Protein Sequence: MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCTLLAAQANKENSNESFISRLLAIVAGLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTEEIDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSLSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNETDHNGDLALDLALSRRLESIATTLVSHKADVDMVDKNGWSLLHKGIQRGDLFASTFLIKNGALVNAATAGAQETPLHLVALYSPKKYSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHLSIMARNDCVFSQLLQCKQLDLELKDHEGSTALWLAVQYITVSSDQSVNPFEDLPVVNGTSFDENSFAARLIQRGSNTDAPDVMTGNCLLQRAAGAGNEAAALFLATSGAHANHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPVPKESPVLMSSADSIYLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGASINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIKHQLPLVVDAICTRGADMSVPDEKGNPPLWLALASNLEDIASTLVRHGCDATCWGPGPSGCLQTLLHRAVDENNESTACFLIRSGCDVNSPRQPGTNGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPVHVAISNQHSVIIQLLISHPNIELSVRDRQGLTPFACAMTYKNNKAAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVQANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRALLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPEYPLDKPDAEGNTVLLLAYMKGNANLCRAIVRSGVRLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSNCYECTAKFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEEEVAKL ------CCHHHHHHH	44.18	-
71	Acetylation	QEQYSDLKIKVGDRH HHHHCCCEEEECCEE	45.53	8275787
73	Acetylation	QYSDLKIKVGDRHIS HHCCCEEEECCEEEH	38.28	8275799
83	Acetylation	DRHISAHKFVLAARS CEEEHHHHEEEEEEC	36.56	8275811
211	Phosphorylation	SLSAQLLYKMIKSKT HHHHHHHHHHHHCCC	13.70	28576409
270	Phosphorylation	ALSRRLESIATTLVS HHHHHHHHHHHHHHH	23.32	-
279	Ubiquitination	ATTLVSHKADVDMVD HHHHHHCCCCHHCCC	38.48	-
636	Ubiquitination	AIQRQDSKSALFLLE HHHCCCCHHHHHHHH	48.30	-
693	Ubiquitination	EKGNPPLWLALASNL CCCCCHHHHHHHCCH	5.83	27667366
700	Ubiquitination	WLALASNLEDIASTL HHHHHCCHHHHHHHH	6.07	27667366
712	Ubiquitination	STLVRHGCDATCWGP HHHHHCCCCCCCCCC	2.35	27667366
848	Acetylation	FACAMTYKNNKAAEA EEEEEEECCCHHHHH	44.90	19852121
851	Acetylation	AMTYKNNKAAEAILK EEEECCCHHHHHHHH	59.37	19852127
851	Ubiquitination	AMTYKNNKAAEAILK EEEECCCHHHHHHHH	59.37	27667366
858	Ubiquitination	KAAEAILKRESGAAE HHHHHHHHCCCCCHH	48.26	27667366
861	Phosphorylation	EAILKRESGAAEQVD HHHHHCCCCCHHHCC	37.45	30635358
870	Ubiquitination	AAEQVDNKGRNFLHV CHHHCCCCCCCEEEE	55.58	27667366
931	Ubiquitination	NLLLAGAKVNELTKH HHHHCCCCHHHHHHH	44.68	-
937	Acetylation	AKVNELTKHRQTALH CCHHHHHHHHHHHHH	49.79	23806337
1008	Phosphorylation	AFNLRGQSPLHILGQ HHCCCCCCCHHHCHH	32.05	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANFY1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANFY1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANFY1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABCA2_HUMAN	ABCA2	physical	26496610
ANXA2_HUMAN	ANXA2	physical	26496610
CX6B1_HUMAN	COX6B1	physical	26496610
RUSD1_HUMAN	RPUSD1	physical	26496610
ANR52_HUMAN	ANKRD52	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.