BPNT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BPNT1_MOUSE
• UniProt AC: Q9Z0S1
• Protein Name: 3'(2'),5'-bisphosphate nucleotidase 1
• Gene Name: Bpnt1
• Organism: Mus musculus (Mouse).
• Sequence Length: 308
• Protein Description: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6..
• Protein Sequence: MASSHTVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSATDLQTKADRLVQMSICSSLARKFPKLTIIGEEDLPPGEVDQELIEDGQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAGPDAALGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNQLVTDCISAMNPDTVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNALQYNKEVKHMNSAGVLAALRNYEYYASHVPESVKNALIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSHTVLM ------CCCCHHHHH	21.53	-
3	Phosphorylation	-----MASSHTVLMR -----CCCCHHHHHH	22.73	24759943
4	Phosphorylation	----MASSHTVLMRL ----CCCCHHHHHHH	17.40	24759943
42	Phosphorylation	LGIVQKTSATDLQTK EEEEECCCCHHHHHH	35.89	25521595
49	Ubiquitination	SATDLQTKADRLVQM CCHHHHHHHHHHHHH	35.02	-
49	Malonylation	SATDLQTKADRLVQM CCHHHHHHHHHHHHH	35.02	26320211
59	S-nitrosylation	RLVQMSICSSLARKF HHHHHHHHHHHHHHC	1.45	21278135
59	S-nitrosocysteine	RLVQMSICSSLARKF HHHHHHHHHHHHHHC	1.45	-
122	Phosphorylation	WVDPLDGTKEYTEGL EECCCCCCHHHHCCH	21.99	27180971
189	Ubiquitination	LKEAPAGKHIITTTR EEECCCCCEEEEECC	33.46	-
189	Malonylation	LKEAPAGKHIITTTR EEECCCCCEEEEECC	33.46	26320211
193	Phosphorylation	PAGKHIITTTRSHSN CCCCEEEEECCCCCC	22.85	20469934
194	Phosphorylation	AGKHIITTTRSHSNQ CCCEEEEECCCCCCC	15.14	20469934
195	Phosphorylation	GKHIITTTRSHSNQL CCEEEEECCCCCCCC	22.86	20469934
197	Phosphorylation	HIITTTRSHSNQLVT EEEEECCCCCCCCHH	29.22	22817900
199	Phosphorylation	ITTTRSHSNQLVTDC EEECCCCCCCCHHHH	27.76	25293948
206	S-nitrosylation	SNQLVTDCISAMNPD CCCCHHHHHHHCCCC	1.61	21278135
206	S-nitrosocysteine	SNQLVTDCISAMNPD CCCCHHHHHHHCCCC	1.61	-
236	Phosphorylation	IEGKASAYVFASPGC EECCCEEEEEECCCC	8.13	-
240	Phosphorylation	ASAYVFASPGCKKWD CEEEEEECCCCCCCC	15.45	26745281
243	S-nitrosylation	YVFASPGCKKWDTCA EEEECCCCCCCCCCC	4.68	21278135
243	S-nitrosocysteine	YVFASPGCKKWDTCA EEEECCCCCCCCCCC	4.68	-
244	Ubiquitination	VFASPGCKKWDTCAP EEECCCCCCCCCCCH	63.91	-
244	Succinylation	VFASPGCKKWDTCAP EEECCCCCCCCCCCH	63.91	-
244	Acetylation	VFASPGCKKWDTCAP EEECCCCCCCCCCCH	63.91	23806337
244	Malonylation	VFASPGCKKWDTCAP EEECCCCCCCCCCCH	63.91	26320211
244	Succinylation	VFASPGCKKWDTCAP EEECCCCCCCCCCCH	63.91	23806337
245	Acetylation	FASPGCKKWDTCAPE EECCCCCCCCCCCHH	55.14	22826441
249	S-nitrosylation	GCKKWDTCAPEVILH CCCCCCCCCHHHHHH	5.72	21278135
249	S-nitrosocysteine	GCKKWDTCAPEVILH CCCCCCCCCHHHHHH	5.72	-
293	Phosphorylation	AALRNYEYYASHVPE HHHHCHHHHHHCCCH	8.25	17242355
296	Phosphorylation	RNYEYYASHVPESVK HCHHHHHHCCCHHHH	14.64	17242355

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BPNT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BPNT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BPNT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BPNT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.