SCYL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCYL1_MOUSE
• UniProt AC: Q9EQC5
• Protein Name: N-terminal kinase-like protein
• Gene Name: Scyl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 806
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm . Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an AR
• Protein Description: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro..
• Protein Sequence: MWFFARDPVRDFPFELSPEPPEGGPPGPWILHRGRKKATGSAVSIFVYDVKPGAEEQTQVAKAAFKRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTYLKARAEAGGLKEQELSWGLHQIVKALSFLVNDCNLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPSKGIPELEQYDPPELADSSSRAVREKWSADMWRLGCLIWEVFNGSLPRAAALRNPGKIPKSLVTHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDSFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKSLRAEEYQEKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVTHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDDQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKILPVLCGLTVDPEKSVRDQAFKTIRSFLSKLESVSEDPTQLAEVEKDVHAASSPGTGGAAASWAGWAVTGVSSLTSKLIRAHPTPVPSDTTVPQRPVPEGNPAPAPALAQAIPATSGHWETQEDKDTAEDSATADRWDDEDWGSLEQEAESVLAQQDDWSAKGQGSRAGQINHPDHKSLESHWSSWEVEGSWDQGWQEPSSVEPPPEGTRLASEYNWGGAEPSDKGDPFAALSVRPSAQPRPDPDSWGEDNWEGLEAESRQVKAELARKKREERRREMEAKRAEKKTTKGPMKLGARKLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RDFPFELSPEPPEGG CCCCCCCCCCCCCCC		26643407
39	Phosphorylation	HRGRKKATGSAVSIF ECCCCCCCCCEEEEE		28066266
41	Phosphorylation	GRKKATGSAVSIFVY CCCCCCCCEEEEEEE		28066266
44	Phosphorylation	KATGSAVSIFVYDVK CCCCCEEEEEEEECC		28066266
275	Phosphorylation	MSNRFVETNLFLEEI CCCCHHHCCCEEEEC		22817900
332	Phosphorylation	NAGAVVLTPLFKVGK CCCEEEEECHHHHCC		26745281
339	Acetylation	TPLFKVGKSLRAEEY ECHHHHCCCCCHHHH		22902405
340	Phosphorylation	PLFKVGKSLRAEEYQ CHHHHCCCCCHHHHH		24719451
448	Phosphorylation	QGPIRCNTTVCLGKI CCCCCCCCEEEEHHH		23140645
460	Phosphorylation	GKIGSYLSASTRHRV HHHHHHCCHHHHHHH		29176673
462	Phosphorylation	IGSYLSASTRHRVLT HHHHCCHHHHHHHHH		29176673
463	Phosphorylation	GSYLSASTRHRVLTS HHHCCHHHHHHHHHH		29176673
532	Phosphorylation	QAFKTIRSFLSKLES HHHHHHHHHHHHHHH		26643407
535	Phosphorylation	KTIRSFLSKLESVSE HHHHHHHHHHHHCCC		24719451
539	Phosphorylation	SFLSKLESVSEDPTQ HHHHHHHHCCCCHHH		26643407
541	Phosphorylation	LSKLESVSEDPTQLA HHHHHHCCCCHHHHH		26643407
558	Phosphorylation	EKDVHAASSPGTGGA HHHHHHHCCCCCCCH		23984901
559	Phosphorylation	KDVHAASSPGTGGAA HHHHHHCCCCCCCHH		23984901
562	Phosphorylation	HAASSPGTGGAAASW HHHCCCCCCCHHHHH		23984901
568	Phosphorylation	GTGGAAASWAGWAVT CCCCHHHHHHHHHHH		23649490
743	Phosphorylation	AALSVRPSAQPRPDP EEEEECCCCCCCCCC		26643407
752	Phosphorylation	QPRPDPDSWGEDNWE CCCCCCCCCCCCCCH		26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCYL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCYL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCYL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GORAB_MOUSE	Gorab	physical	12783284

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.