CE290_MOUSE - dbPTM
CE290_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CE290_MOUSE
UniProt AC Q6A078
Protein Name Centrosomal protein of 290 kDa
Gene Name Cep290 {ECO:0000312|MGI:MGI:2384917}
Organism Mus musculus (Mouse).
Sequence Length 2472
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centr
Protein Description Involved in early and late steps in cilia formation. [PubMed: 21565611 Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (By similarity May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (By similarity Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes]
Protein Sequence MPPNIKWKELIKVDPDDLPRQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGLTIDDLNLSETFSHENKIEGRKLNFMSLNNMNETQSKNEFLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKKKNLDLENDILYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKELESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETEQELIRELQLLRLANNQMDKERAELIHQIEINKDQTRADSSIPDSDQLKEKINDLETQLRKLELEKQHSKEEVKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKLKKLSEQFGFELPSPLAASEHSEDGESPHSFPIY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
104PhosphorylationELEMAQQSAGGRDTR
HHHHHHHHCCCCCHH		19.4625338131
239PhosphorylationMRKNLEESVQEMEKM
HHHCHHHHHHHHHHH		21.5227841257
260PhosphorylationMKALVHQSDAVMDQI
HHHHHHCHHHHHHHH		16.80-
414PhosphorylationVQILEEKTKEAERIA
HHHHHHHHHHHHHHH		37.0823649490
950PhosphorylationLQKVIDNSVSLSELE
HHHHHHCCCCHHHHH		14.8825159016
952PhosphorylationKVIDNSVSLSELELA
HHHHCCCCHHHHHHH		26.4625159016
954PhosphorylationIDNSVSLSELELANK
HHCCCCHHHHHHHHH		32.4025159016
1005PhosphorylationKEQMEAISKELEITK
HHHHHHHHHHHHHHH		27.42-
1138PhosphorylationRILELEKSEVELKVE
HHHHHHHHHHHHEEH		37.18-
1147PhosphorylationVELKVEVSKLREISD
HHHEEHHHHHHHHHH		16.6823140645
1491PhosphorylationLAEQNILSRDKVINE
HHHHCCCCHHHHHHH		34.3425159016
1693UbiquitinationHALAQAHKDSQSLKS
HHHHHHHHHHHHHHH		63.19-
1857PhosphorylationRLSSGLQSKTLIDNK
HHHHHCCCCHHHCCH		32.42-
1866PhosphorylationTLIDNKQSLIDELQK
HHHCCHHHHHHHHHH		28.9725338131
1898PhosphorylationIKPVKEKSSKEELIR
CCCCCCCCCHHHHHH		47.9730482847
1899PhosphorylationKPVKEKSSKEELIRW
CCCCCCCCHHHHHHH		55.9730482847
1960PhosphorylationTLQKKLKTTGMTVDQ
HHHHHHHHCCCCHHH		38.7328576409
1961PhosphorylationLQKKLKTTGMTVDQV
HHHHHHHCCCCHHHH		24.3028576409
1964PhosphorylationKLKTTGMTVDQVLGV
HHHHCCCCHHHHHHH		23.4428576409
2168AcetylationEEENRNLKAELEKLK
HHHHHHHHHHHHHHH		43.2822902405
2173AcetylationNLKAELEKLKAHFGR
HHHHHHHHHHHHHHH		68.8322902405
2457PhosphorylationLPSPLAASEHSEDGE
CCCCCCCCCCCCCCC		30.1826643407
2460PhosphorylationPLAASEHSEDGESPH
CCCCCCCCCCCCCCC		33.0726643407
2465PhosphorylationEHSEDGESPHSFPIY
CCCCCCCCCCCCCCC		33.1826643407
2468PhosphorylationEDGESPHSFPIY---
CCCCCCCCCCCC---		35.7826643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CE290_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CE290_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CE290_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CASA1_BOVINCSN1S1physical
21565611
DCD_HUMANDCDphysical
21565611
K2C1_HUMANKRT1physical
21565611
K1C9_HUMANKRT9physical
21565611
K2C6B_HUMANKRT6Bphysical
21565611
K2C5_HUMANKRT5physical
21565611
K1C10_HUMANKRT10physical
21565611
K1C16_HUMANKRT16physical
21565611
K1C14_HUMANKRT14physical
21565611
HORN_HUMANHRNRphysical
21565611
K2C6A_HUMANKRT6Aphysical
21565611
LYSC_CHICKLYZphysical
21565611
TBB5_MOUSETubb5physical
21565611
PLAK_MOUSEJupphysical
21565611
HSP7C_MOUSEHspa8physical
21565611
UBB_MOUSEUbbphysical
21565611
CEP97_MOUSECep97physical
21565611
IQCB1_MOUSEIqcb1physical
21565611
TBA1B_MOUSETuba1bphysical
21565611
M4K4_MOUSEMap4k4physical
21565611
F13B_MOUSEF13bphysical
21565611
LDHB_MOUSELdhbphysical
21565611
PCM1_MOUSEPcm1physical
21565611
PYRD_MOUSEDhodhphysical
21565611
CRYAB_MOUSECryabphysical
21565611
CP110_MOUSECcp110physical
21565611
NEUL4_MOUSENeurl4physical
21565611
K2C5_MOUSEKrt5physical
21565611
KCMA1_MOUSEKcnma1physical
21565611
C102A_MOUSECcdc102aphysical
21565611
CC110_MOUSECcdc110physical
21565611
PCM1_HUMANPCM1physical
26496610
OFD1_HUMANOFD1physical
26496610
IQCB1_HUMANIQCB1physical
26496610
CP110_HUMANCCP110physical
26496610
CP131_HUMANCEP131physical
26496610
RT17_HUMANMRPS17physical
26496610
CEP72_HUMANCEP72physical
26496610
CEP97_HUMANCEP97physical
26496610
CCD77_HUMANCCDC77physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CE290_MOUSE

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Related Literatures of Post-Translational Modification

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