| UniProt ID | IQCB1_MOUSE | |
|---|---|---|
| UniProt AC | Q8BP00 | |
| Protein Name | IQ calmodulin-binding motif-containing protein 1 | |
| Gene Name | Iqcb1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 598 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localization to the centrosome depends on the interaction with CEP290. | |
| Protein Description | Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (By similarity).. | |
| Protein Sequence | MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSSELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEEFYKELLPSAAENFLILGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHVQLIQNVLQSDHFLHLLQTDNVQIGASVMTLLQNILQINSGNLLKIEGKALHSILDEILFKLLSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQLVDLLTPKIHQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRSKRTKMMLELNRQKEEEDLRLKLQLQRQRAMRLSRESRLNMLEIIHPGQVEKYNREMEEKSALTIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQELTDARRVELKQQVDDYVKRHPCSQMSEAASRELHAQAQERLQHYFMGRAIEERAQQHREALMAQISTNIEQLMKAPSLKEAEGKEPEQFLSRSRPVAAKAKQAHLTTLKHIQAPWWKKLGEEPGDEVDVPKDELSIDLGMLFIGGTKPP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 205 | Ubiquitination | NLLKIEGKALHSILD CCEEECHHHHHHHHH | 34.68 | - | |
| 259 | Phosphorylation | ACYKGLRSLLNKQET HHHHHHHHHHCCHHH | 42.10 | 29899451 | |
| 319 | Phosphorylation | KRLKKLPSAVIALQR HHHHHCCHHHHHHHH | 45.67 | 29899451 | |
| 327 | Phosphorylation | AVIALQRSFRSKRTK HHHHHHHHHHHHHHH | 16.43 | 29514104 | |
| 363 | Phosphorylation | RQRAMRLSRESRLNM HHHHHHCCHHHHCCH | 24.52 | 29899451 | |
| 366 | Phosphorylation | AMRLSRESRLNMLEI HHHCCHHHHCCHHHH | 40.74 | 29899451 | |
| 413 | Phosphorylation | NFRQQRPSLTEYKAA CHHHHCCCHHHHHHH | 50.54 | 29899451 | |
| 443 | Phosphorylation | KKKKLFASWHGLQEL HCHHHHHHHHCHHHH | 16.57 | 20139300 | |
| 558 | Acetylation | QAHLTTLKHIQAPWW HHHHHHHHHCCCHHH | 36.25 | 22902405 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IQCB1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IQCB1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IQCB1_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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