dbPTM

K1C10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K1C10_MOUSE
UniProt AC	P02535
Protein Name	Keratin, type I cytoskeletal 10
Gene Name	Krt10
Organism	Mus musculus (Mouse).
Sequence Length	570
Subcellular Localization
Protein Description	Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization..
Protein Sequence	MSVLYSSSSKQFSSSRSGGGGGGGSVRVSSTRGSLGGGYSSGGFSGGSFSRGSSGGGCFGGSSGGYGGFGGGGSFGGGYGGSSFGGGYGGSSFGGGYGGSSFGGAGFGGGGSFGGGSFGGGSYGGGFGGGGFGGDGGSLLSGNGRVTMQNLNDRLASYMDKVRALEESNYELEGKIKEWYEKHGNSSQREPRDYSKYYKTIEDLKGQILTLTTDNANVLLQIDNARLAADDFRLKYENEVTLRQSVEADINGLRRVLDELTLSKSDLEMQIESLNEELAYLKKNHEEEMRDLQNVSTGDVNVEMNAAPGVDLTQLLNNMRNQYEQLAEKNRKDAEEWFNQKSKELTTEIDSNIEQMSSHKSEITELRRTVQGLEIELQSQLALKQSLEASLAETEGRYCVQLSQIQSQISALEEQLQQIRAETECQNAEYQQLLDIKTRLENEIQTYRSLLEGEGSSSGGGGGRRGGSGGGSYGGSSGGGSYGGSSGGGGSYGGSSGGGGSYGGGSSGGGSHGGSSGGGYGGGSSSGGAGGHGGSSGGGYGGGSSSGGQGGSGGFKSSGGGDQSSKGPRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVLYSSSS ------CCEECCCCC	22.34	26643407
5	Phosphorylation	---MSVLYSSSSKQF ---CCEECCCCCCCC	12.35	26643407
6	Phosphorylation	--MSVLYSSSSKQFS --CCEECCCCCCCCC	21.41	26643407
7	Phosphorylation	-MSVLYSSSSKQFSS -CCEECCCCCCCCCC	25.69	26643407
8	Phosphorylation	MSVLYSSSSKQFSSS CCEECCCCCCCCCCC	35.30	26643407
9	Phosphorylation	SVLYSSSSKQFSSSR CEECCCCCCCCCCCC	32.21	26643407
10	Acetylation	VLYSSSSKQFSSSRS EECCCCCCCCCCCCC	58.26	15616681
13	Phosphorylation	SSSSKQFSSSRSGGG CCCCCCCCCCCCCCC	25.55	26643407
14	Phosphorylation	SSSKQFSSSRSGGGG CCCCCCCCCCCCCCC	30.93	26643407
15	Phosphorylation	SSKQFSSSRSGGGGG CCCCCCCCCCCCCCC	29.30	26643407
17	Phosphorylation	KQFSSSRSGGGGGGG CCCCCCCCCCCCCCC	43.68	-
29	Phosphorylation	GGGSVRVSSTRGSLG CCCCEEEECCCCCCC	18.54	22817900
30	Phosphorylation	GGSVRVSSTRGSLGG CCCEEEECCCCCCCC	21.19	22817900
31	Phosphorylation	GSVRVSSTRGSLGGG CCEEEECCCCCCCCC	31.38	22817900
32	Asymmetric dimethylarginine	SVRVSSTRGSLGGGY CEEEECCCCCCCCCC	34.35	-
32	Methylation	SVRVSSTRGSLGGGY CEEEECCCCCCCCCC	34.35	24129315
34	Phosphorylation	RVSSTRGSLGGGYSS EEECCCCCCCCCCCC	22.13	22817900
39	Phosphorylation	RGSLGGGYSSGGFSG CCCCCCCCCCCCCCC	11.70	21082442
40	Phosphorylation	GSLGGGYSSGGFSGG CCCCCCCCCCCCCCC	26.28	19367708
41	Phosphorylation	SLGGGYSSGGFSGGS CCCCCCCCCCCCCCC	34.16	22817900
45	Phosphorylation	GYSSGGFSGGSFSRG CCCCCCCCCCCCCCC	45.58	22817900
48	Phosphorylation	SGGFSGGSFSRGSSG CCCCCCCCCCCCCCC	24.47	22817900
50	Phosphorylation	GFSGGSFSRGSSGGG CCCCCCCCCCCCCCC	37.11	22817900
157	Phosphorylation	NLNDRLASYMDKVRA CHHHHHHHHHHHHHH	26.11	20139300
168	Phosphorylation	KVRALEESNYELEGK HHHHHHHCCCCCHHH	35.02	-
263	Phosphorylation	VLDELTLSKSDLEMQ HHHHHCCCHHHHHHH	25.52	19367708
351	Phosphorylation	ELTTEIDSNIEQMSS HHHHHHHHHHHHHHH	45.42	19367708
457	Phosphorylation	LLEGEGSSSGGGGGR HHCCCCCCCCCCCCC	43.81	19367708

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K1C10_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K1C10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K1C10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of K1C10_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K1C10_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-48 AND SER-351,AND MASS SPECTROMETRY.	19367708 [Abstract]