K1C14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C14_MOUSE
• UniProt AC: Q61781
• Protein Name: Keratin, type I cytoskeletal 14
• Gene Name: Krt14
• Organism: Mus musculus (Mouse).
• Sequence Length: 484
• Subcellular Localization: Cytoplasm. Nucleus. Expressed in both as a filamentous pattern..
• Protein Description: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro..
• Protein Sequence: MATCSRQFTSSSSMKGSCGIGGGSSRMSSILAGGSCRAPSTYGGMSVTSSRFSSGGACGIGGGYGGSFSSSSFGGGLGSGFGGRFDGFGGGFGGGLGGGFGGGLGGGLGGGIGDGLLVGSEKVTMQNLNDRLATYLDKVRALEEANTELEVKIRDWYQRQRPTEIKDYSPYFKTIEDLKSKILAATVDNANVLLQIDNARLAADDFRTKFETEQSLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFSKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSSSQFSSGSQSSRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	TCSRQFTSSSSMKGS CCCCCCCCCCCCCCC	29.52	-
11	Phosphorylation	CSRQFTSSSSMKGSC CCCCCCCCCCCCCCC	24.31	21183079
12	Phosphorylation	SRQFTSSSSMKGSCG CCCCCCCCCCCCCCC	33.93	19060867
13	Phosphorylation	RQFTSSSSMKGSCGI CCCCCCCCCCCCCCC	26.85	22817900
17	Phosphorylation	SSSSMKGSCGIGGGS CCCCCCCCCCCCCCC	12.03	21082442
24	Phosphorylation	SCGIGGGSSRMSSIL CCCCCCCCCCCCHHH	20.32	19367708
28	Phosphorylation	GGGSSRMSSILAGGS CCCCCCCCHHHCCCC	17.08	22817900
29	Phosphorylation	GGSSRMSSILAGGSC CCCCCCCHHHCCCCC	16.57	19367708
35	Phosphorylation	SSILAGGSCRAPSTY CHHHCCCCCCCCCCC	10.26	22817900
40	Phosphorylation	GGSCRAPSTYGGMSV CCCCCCCCCCCCEEE	33.02	22817900
179	Acetylation	FKTIEDLKSKILAAT CCCHHHHHHHHHEEE	63.12	7719567
181	Acetylation	TIEDLKSKILAATVD CHHHHHHHHHEEECC	39.90	7719577
209	Ubiquitination	AADDFRTKFETEQSL CCHHHHHHHHCHHHH	36.63	-
212	Phosphorylation	DFRTKFETEQSLRMS HHHHHHHCHHHHHHH	42.32	21454597
219	Phosphorylation	TEQSLRMSVEADING CHHHHHHHHHHCHHH	15.46	21454597
265	Phosphorylation	NHEEEMASMRGQVGG CCHHHHHHHHCCCCC	14.01	30635358
314	Phosphorylation	DAEEWFFSKTEELNR HHHHHHHHCHHHHCH	29.24	23375375
356	Phosphorylation	IELQSQLSMKASLEN HHHHHHHHHHHHHHC	15.59	22817900
360	Phosphorylation	SQLSMKASLENNLEE HHHHHHHHHHCCHHH	30.60	28507225
439	Phosphorylation	LSSSQFSSSSQFSSG CCCCCCCCCCCCCCC	34.98	-
441	Phosphorylation	SSQFSSSSQFSSGSQ CCCCCCCCCCCCCCC	36.87	19367708
444	Phosphorylation	FSSSSQFSSGSQSSR CCCCCCCCCCCCCCC	26.59	22817900
445	Phosphorylation	SSSSQFSSGSQSSRD CCCCCCCCCCCCCCC	43.69	22817900
447	Phosphorylation	SSQFSSGSQSSRDVT CCCCCCCCCCCCCCH	28.92	22705788
449	Phosphorylation	QFSSGSQSSRDVTST CCCCCCCCCCCCHHH	29.10	22817900
450	Phosphorylation	FSSGSQSSRDVTSTN CCCCCCCCCCCHHHC	25.51	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C14_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C14_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K1C14_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.