FTM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FTM_MOUSE
• UniProt AC: Q8CG73
• Protein Name: Protein fantom
• Gene Name: Rpgrip1l
• Organism: Mus musculus (Mouse).
• Sequence Length: 1264
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell junction, tight junction . In cultured renal cells, it localizes diffusely in t
• Protein Description: Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. [PubMed: 22927466 Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2]
• Protein Sequence: MSGPSDETAGDLPVKDTGLNLFGVGGLQETSTARTVKTRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSRVQARVNTGRRRASASAGSQECPGKGLRFQNVDEAETVQPTLTKYSNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSNIRDNVETIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNKQLKEQRLKCCSLEKQLHSVRFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQMKVQIAQLETALKSDLTDKTEVLDKLKTERDQNEKLVQENRDLQLQCLQQKQRLHELQSRLKFFNQESDINADDLSEALLLIKAQKEQKNGDLSFLEKVDSKINKDLDRSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVETVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLRASGDKELVTFCTYAFYDFELQTTPIVRGLYPEYNFTSQYLVHVNDLFLQYIQKNTVTLELHQAHSTDYETIAACQLRFHEILEKSGRIFCTTSLVGTKGDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKKPEKMQLSSQQAATTAQISPAESTDGNLNELHVTVKCCTGLQSRASYLQPHAYVVYKFFDFPDHDTAIVPSSNDPQFDDHMCFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYMGKVNVPLISLAHDKCISGIFELMDKEKHAAGTIQVILKWKFTYLPPSGSITTEDLGKFVCREEPEAVQRLPPKSSDVTSVVAPKPKPRQRLTFVDKKVSFADTISHPSPETSPPPKDIKDSSPEVGPKPENGLSAVAYPSKESGVAKVEENVGEMQQGKEDDISFLSEGQLASGSVASSEDETEITEELEPEDEDRSASDSDDCIIPSSVSTNTKQPSEEIRIEIIALNLNDSQITREDTIQRLFIECRFYSLPAEETPMSLPKPQSGQWVYYNYSNVIYLDKENNPAVRDILKAILQRRELPHRSVRFTVVSDPPEDEQDLECEDIGVAHVDLADLFQKGRDIIEQDIDVLDARTDGGTIGKLKVTVEALHALRSVYEQNRKDLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGPSDETA ------CCCCCCCCC	71.38	25338131
150	Phosphorylation	QGHRQTSYSRVQARV CCCCCCCHHHHHHHH	12.13	29514104
159	Phosphorylation	RVQARVNTGRRRASA HHHHHHHHCCCCCCC	29.25	22942356
165	Phosphorylation	NTGRRRASASAGSQE HHCCCCCCCCCCCCC	22.42	29899451
167	Phosphorylation	GRRRASASAGSQECP CCCCCCCCCCCCCCC	30.57	29899451
574	Phosphorylation	AQLKDIAYGTKQYKF HHHHHHHHCCCCCCC	26.17	23140645
576	Phosphorylation	LKDIAYGTKQYKFKP HHHHHHCCCCCCCCC	11.42	23140645
579	Phosphorylation	IAYGTKQYKFKPEIM HHHCCCCCCCCCCCC	21.68	29895711
969	Phosphorylation	PKPRQRLTFVDKKVS CCCCCCEEEECEECC	24.65	29514104
976	Phosphorylation	TFVDKKVSFADTISH EEECEECCCCHHCCC	24.48	25777480
980	Phosphorylation	KKVSFADTISHPSPE EECCCCHHCCCCCCC	22.43	25293948
982	Phosphorylation	VSFADTISHPSPETS CCCCHHCCCCCCCCC	31.29	25293948
985	Phosphorylation	ADTISHPSPETSPPP CHHCCCCCCCCCCCC	29.91	27087446
988	Phosphorylation	ISHPSPETSPPPKDI CCCCCCCCCCCCCCC	50.33	23375375
989	Phosphorylation	SHPSPETSPPPKDIK CCCCCCCCCCCCCCC	33.47	27087446
998	Phosphorylation	PPKDIKDSSPEVGPK CCCCCCCCCCCCCCC	42.67	25338131
999	Phosphorylation	PKDIKDSSPEVGPKP CCCCCCCCCCCCCCC	34.90	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FTM_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FTM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FTM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RLA1_MOUSE	Rplp1	physical	21565611
RS15A_MOUSE	Rps15a	physical	21565611
PSMD3_MOUSE	Psmd3	physical	21565611
PSD11_MOUSE	Psmd11	physical	21565611
PP2AA_MOUSE	Ppp2ca	physical	21565611
PRS8_MOUSE	Psmc5	physical	21565611
RABE1_MOUSE	Rabep1	physical	21565611
1433E_MOUSE	Ywhae	physical	21565611
1433Z_MOUSE	Ywhaz	physical	21565611
RS14_MOUSE	Rps14	physical	21565611
PASK_MOUSE	Pask	physical	21565611
RS3A_MOUSE	Rps3a1	physical	21565611
RS6_MOUSE	Rps6	physical	21565611
RS3_MOUSE	Rps3	physical	21565611
RS4X_MOUSE	Rps4x	physical	21565611
CUL4A_MOUSE	Cul4a	physical	21565611
RSSA_MOUSE	Rpsa	physical	21565611
EXC6B_MOUSE	Exoc6b	physical	21565611
PPR21_MOUSE	Ppp1r21	physical	21565611
VAT1_MOUSE	Vat1	physical	21565611
RS27L_MOUSE	Rps27l	physical	21565611
THIM_MOUSE	Acaa2	physical	21565611
RS16_MOUSE	Rps16	physical	21565611
FKB14_MOUSE	Fkbp14	physical	21565611
SOBP_MOUSE	Sobp	physical	21565611
GOGA4_MOUSE	Golga4	physical	21565611
CE042_MOUSE	2410089E03Rik	physical	21565611
ZC12D_MOUSE	Zc3h12d	physical	21565611
CCHCR_MOUSE	Cchcr1	physical	21565611
RS19_MOUSE	Rps19	physical	21565611
UTP4_MOUSE	Cirh1a	physical	21565611
1433G_MOUSE	Ywhag	physical	21565611
TF7L1_MOUSE	Tcf7l1	physical	21565611
RL11_MOUSE	Rpl11	physical	21565611
RS7_MOUSE	Rps7	physical	21565611
RLA0_MOUSE	Rplp0	physical	21565611
RS28_MOUSE	Rps28	physical	21565611
1433T_MOUSE	Ywhaq	physical	21565611
NPHP4_MOUSE	Nphp4	physical	21565611
NPHP1_MOUSE	Nphp1	physical	21565611

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.