GOGA4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GOGA4_MOUSE
• UniProt AC: Q91VW5
• Protein Name: Golgin subfamily A member 4
• Gene Name: Golga4
• Organism: Mus musculus (Mouse).
• Sequence Length: 2238
• Subcellular Localization: Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Golgi apparatus, trans-Golgi network membrane .
• Protein Description: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking..
• Protein Sequence: MFKKLKQKISEEQQQLQQALAPAQASSSSSTPTRTRSRTSSFTDQLDDVTPNRENASTQATKSPDGVSKDESSPSQSGDTQTFAQKLQLRVPSMESLFRSPIKESLFRSSKEPLVRTSSRESLNQLDLDCSAAAFDPPSDMESEAEDAPWNSDGLSREQLLQRLRRMERSLSSYRGKYSELVTAFQTLQREKKKLQGILSQSQDKSLRRISELREELQMDQQAKKHLQDEFDACLEEKDQYISVLQTQVSLLKQRLQNGPMNVDAPKPLPPGELQAEVHGDTEKMEGVGEPVGGGTSAKTLEMLQQRVKRQENLLQRCKETIGSHKEQCALLLSEKEALQEQLDERLQELEKMKELHMAEKTKLITQLRDAKNLIEQLEQDKGMVITETKRQMLETLELKEDEIAQLRSHIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEDAQRRMKMEMDEQMKAVERASEEERLRLQHELSRVRQEAASMAKKNSEEQVAALQKLHAEELASKEQELSRRLEARERELQEQMRIALEKSRSEYLKLTQEKEQQESLALEELELQKKAILTESENKLQELGQEAEAYRTRILELETSLEKSLQESKTQSEHLAVHLEAEKNKHNKELTALAEQHRTEVEGLQQQQDSLWTERLQSLSQQHQAAVEELREKYQQEKDALLKEKESLFQAHIQDMNEKTLEKLDKKQMELESVSSELSEALRARDQLAEELSVLRGDADKMKQALEAELEEQRRHHQREVGSISEQQELTVRRAEKALKDELSRLGALLDERDEHLRERQARVQDLEAHLQKSAGELQQALAKLDLLHSEQSAAREQAGAYEEQLAQMQQKVLDLETEKSLLTKQVVEMETHKKHVCEELDAQRAQVQQLERQRSELEEKVRSLAQLQDSQLKNSTVEKEQARQSLMEKENIILQMREEQAKEIEILKQTLSSKEESISILHEEYETKFKNQEKRMEKIKQKAKEMQETKKKLLDQEAKLKKELENTVLELSQKEKQFNAQILEMAQANSAGISDTVSRLEENQRQQIESLTGAHQRKLDDVIEAWEKKLSQQAAELRDKHAEQMEEKEQGLGELRQKVRIVQSEKEELTKEVARLKEAVSGQDVALAGLQGQLEQKSAVIVSLSERESQLQSQVEKLEADLGCSLSEKLSLQEELAELKLLADKSQLRVSELTGQVQAAEKELQSCKSLHELSKKSLEDKSLNLKSLLEELASQLDSRCERTKALLEAKTNELVCTSRDKADAILARLSQCQRHTATVGEALLRRMGQVSELEAQLTQLTEEQRTLKSSFQQVTNQLEEKEKQIKTMKADIEGLLTEKEALQQEGGQQRQAASEKESCITQLKKELAENINAVTLLREELSEKKSEIASLSKQLSDLGAQLESSISPSDKAEAISALSKQHEEQELQLQAQLQELSLKVDALSKEKMSALEQVDHWSNKFSEWKKKAQSRLAQHQSTIKDLQAQLDVKATDAREKEEQICLLKEDLDRQNKKFECLKGEMEVRKSKMEKKECDLETALKTQTARVVELEDCVTQRKKEVESLNETLKNYNQQRDTEHSGLVQRLQHLEELGEEKDNKVREAEETVLRLREHVSSLEAELGTVKKELEHVNSSVKSRDGELKALEDKLELESAAKVELKRKAEQKIAAIRKQLLSQMEEKTQRYAKDTENRLSELSAQLKEREKQVHSLEDKLKNLESSPHPEVPAVSRSMQSVAASPEQEAPDSQDCTHKACKERLCMLQRRLSEKEKLLRRLEQGEGEARPSQPEAQHRALSGKLDCTRARQLEDHVLIGCLPEELEEKMKCSLIVSQPMGEETGNNTGVKQNWASVVDSVQKTLQEKELTCQALEQRVKELESDLVRERGAHRLEVEKLTLKYEKSQSSQQEMDGENKCVEVLEDRPEENSQSHEIQSNVGTVDGLRSDLESKLTGAERDKQKLSKEVARLQKELRALRREHQQELDILKRECEQEAEEKLKQEQEDLELKHTSTLKQLMREFNTQLAQKEQELERTVQETIDKAQEVEAELLESHQEETQQLHRKIAEKEDDLRRTARRYEEILDAREEEMTGKVTDLQTQLEELQKKYQQRLEQEESTKDSVTILELQTQLAQKTTLISDSKLKEQELREQVHNLEDRLKRYEKNACAATVGTPYKGGNLYHTEVSLFGEPTEFEYLRKVMFEYMMGRETKTMAKVITTVLKFPDDQAQKILEREDARLMSWLRTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KKLKQKISEEQQQLQ HHHHHHHHHHHHHHH	41.96	28973931
26	Phosphorylation	ALAPAQASSSSSTPT HHHHHHHCCCCCCCC	20.76	28576409
27	Phosphorylation	LAPAQASSSSSTPTR HHHHHHCCCCCCCCC	36.94	29899451
29	Phosphorylation	PAQASSSSSTPTRTR HHHHCCCCCCCCCCC	39.93	25338131
31	Phosphorylation	QASSSSSTPTRTRSR HHCCCCCCCCCCCCC	30.54	23384938
33	Phosphorylation	SSSSSTPTRTRSRTS CCCCCCCCCCCCCCC	44.77	29899451
37	Phosphorylation	STPTRTRSRTSSFTD CCCCCCCCCCCCCHH	39.02	27742792
39	Phosphorylation	PTRTRSRTSSFTDQL CCCCCCCCCCCHHCC	29.93	25521595
40	Phosphorylation	TRTRSRTSSFTDQLD CCCCCCCCCCHHCCC	23.50	25521595
41	Phosphorylation	RTRSRTSSFTDQLDD CCCCCCCCCHHCCCC	31.39	25521595
43	Phosphorylation	RSRTSSFTDQLDDVT CCCCCCCHHCCCCCC	25.45	25521595
50	Phosphorylation	TDQLDDVTPNRENAS HHCCCCCCCCCCCCC	23.11	25777480
57	Phosphorylation	TPNRENASTQATKSP CCCCCCCCCCCCCCC	32.41	25367039
58	Phosphorylation	PNRENASTQATKSPD CCCCCCCCCCCCCCC	21.58	25777480
61	Phosphorylation	ENASTQATKSPDGVS CCCCCCCCCCCCCCC	23.41	25777480
63	Phosphorylation	ASTQATKSPDGVSKD CCCCCCCCCCCCCCC	24.70	25619855
68	Phosphorylation	TKSPDGVSKDESSPS CCCCCCCCCCCCCCC	39.66	25619855
72	Phosphorylation	DGVSKDESSPSQSGD CCCCCCCCCCCCCCC	58.65	25619855
73	Phosphorylation	GVSKDESSPSQSGDT CCCCCCCCCCCCCCH	26.90	25619855
75	Phosphorylation	SKDESSPSQSGDTQT CCCCCCCCCCCCHHH	38.64	25619855
77	Phosphorylation	DESSPSQSGDTQTFA CCCCCCCCCCHHHHH	42.87	25619855
80	Phosphorylation	SPSQSGDTQTFAQKL CCCCCCCHHHHHHHH	32.79	25619855
93	Phosphorylation	KLQLRVPSMESLFRS HHCCCCCCHHHHHCC	32.12	25521595
94	Oxidation	LQLRVPSMESLFRSP HCCCCCCHHHHHCCH	3.12	17242355
96	Phosphorylation	LRVPSMESLFRSPIK CCCCCHHHHHCCHHH	24.94	27742792
100	Phosphorylation	SMESLFRSPIKESLF CHHHHHCCHHHHHHH	24.52	22817900
117	Phosphorylation	SKEPLVRTSSRESLN CCCCCCCCCCHHHHH	24.47	26643407
118	Phosphorylation	KEPLVRTSSRESLNQ CCCCCCCCCHHHHHH	19.48	23984901
119	Phosphorylation	EPLVRTSSRESLNQL CCCCCCCCHHHHHHC	39.18	26643407
122	Phosphorylation	VRTSSRESLNQLDLD CCCCCHHHHHHCCCC	31.35	26643407
131	Phosphorylation	NQLDLDCSAAAFDPP HHCCCCCCCCCCCCC	22.17	23984901
139	Phosphorylation	AAAFDPPSDMESEAE CCCCCCCCCCCCCCC	55.78	26643407
143	Phosphorylation	DPPSDMESEAEDAPW CCCCCCCCCCCCCCC	35.15	23649490
172	Phosphorylation	RRMERSLSSYRGKYS HHHHHHHHHHHHCHH	26.94	24719451
211	Phosphorylation	DKSLRRISELREELQ HHHHHHHHHHHHHHH	28.85	25777480
396	Phosphorylation	TKRQMLETLELKEDE HHHHHHHHHCCCHHH	22.90	27180971
416	Phosphorylation	SHIKQMTTQGEELRE HHHHHHHHHHHHHHH	29.27	22802335
488	Phosphorylation	RVRQEAASMAKKNSE HHHHHHHHHHHCCHH	26.73	20495213
599	Phosphorylation	LETSLEKSLQESKTQ HHHHHHHHHHHCCCH	26.38	28059163
682	Phosphorylation	ALLKEKESLFQAHIQ HHHHHHHHHHHHHHH	45.62	29514104
758	Phosphorylation	HHQREVGSISEQQEL HHHHHHCCHHHHHHH	28.28	26745281
760	Phosphorylation	QREVGSISEQQELTV HHHHCCHHHHHHHHH	30.93	26745281
809	Phosphorylation	LEAHLQKSAGELQQA HHHHHHHCHHHHHHH	28.66	27180971
856	Phosphorylation	LDLETEKSLLTKQVV HCHHHHHHHHHHHHH	23.52	24719451
891	Phosphorylation	QQLERQRSELEEKVR HHHHHHHHHHHHHHH	37.89	22006019
946	Phosphorylation	EIEILKQTLSSKEES HHHHHHHHHCCCHHH	27.33	25293948
948	Phosphorylation	EILKQTLSSKEESIS HHHHHHHCCCHHHHH	42.63	24759943
949	Phosphorylation	ILKQTLSSKEESISI HHHHHHCCCHHHHHH	47.39	24759943
1008	Phosphorylation	ENTVLELSQKEKQFN HHHHHHHHHHHHHHH	29.81	29899451
1010	Ubiquitination	TVLELSQKEKQFNAQ HHHHHHHHHHHHHHH	64.60	22790023
1218	Phosphorylation	KKSLEDKSLNLKSLL HHHHHCCCCCHHHHH	34.51	-
1392	Phosphorylation	ASLSKQLSDLGAQLE HHHHHHHHHHHHHHH	28.44	23984901
1400	Phosphorylation	DLGAQLESSISPSDK HHHHHHHCCCCHHHH	41.38	23984901
1401	Phosphorylation	LGAQLESSISPSDKA HHHHHHCCCCHHHHH	20.08	23984901
1403	Phosphorylation	AQLESSISPSDKAEA HHHHCCCCHHHHHHH	21.94	23984901
1405	Phosphorylation	LESSISPSDKAEAIS HHCCCCHHHHHHHHH	44.98	23984901
1715	Phosphorylation	KLKNLESSPHPEVPA HHHCCCCCCCCCCCC	20.18	25338131
1729	Phosphorylation	AVSRSMQSVAASPEQ CCCHHHHHHHCCCCC	12.70	30635358
1733	Phosphorylation	SMQSVAASPEQEAPD HHHHHHCCCCCCCCC	21.16	30635358
1761	Phosphorylation	CMLQRRLSEKEKLLR HHHHHHHHHHHHHHH	44.82	24719451
1952	Acetylation	GAERDKQKLSKEVAR CHHHHHHHHHHHHHH	61.54	23806337
1955	Acetylation	RDKQKLSKEVARLQK HHHHHHHHHHHHHHH	67.65	23806337
2112	Phosphorylation	QEESTKDSVTILELQ HHHCCHHHHHHHHHH	23.79	22871156
2126	Phosphorylation	QTQLAQKTTLISDSK HHHHHHHHCCCCCHH	18.11	22817900
2127	Phosphorylation	TQLAQKTTLISDSKL HHHHHHHCCCCCHHH	29.18	22817900
2132	Phosphorylation	KTTLISDSKLKEQEL HHCCCCCHHHCHHHH	32.85	22871156
2161	Phosphorylation	EKNACAATVGTPYKG HHCCCCCCCCCCCCC	10.84	28066266
2164	Phosphorylation	ACAATVGTPYKGGNL CCCCCCCCCCCCCCE	21.07	28066266
2166	Phosphorylation	AATVGTPYKGGNLYH CCCCCCCCCCCCEEE	23.31	28066266
2237	Phosphorylation	LMSWLRTSS------ HHHHHHCCC------	27.84	21183079
2238	Phosphorylation	MSWLRTSS------- HHHHHCCC-------	43.56	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GOGA4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GOGA4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GOGA4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GOGA4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.
PubMed: 17242355