| UniProt ID | NPHP1_MOUSE | |
|---|---|---|
| UniProt AC | Q9QY53 | |
| Protein Name | Nephrocystin-1 | |
| Gene Name | Nphp1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 687 | |
| Subcellular Localization | Cell junction, adherens junction. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction. Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions. Localized to respiratory cilia axone | |
| Protein Description | Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells, together with NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis; required for the differentiation of early elongating spermatids into spermatozoa.. | |
| Protein Sequence | MLARRPRDPLQALRRRGQELKLQVDSLVTESQLTGALEPSKRREIYQRCIQLKQAVDENKNTLQKLNKADEAAPVGNYEQRKEEEHSLLEKLACQLQELAVSISRKDALKVEAHSDKEEDDTTEDDEEETGGEEEESEGDGEGKQEQASPKQAETETVTYIALGDFAAQQTGDLTFKKGDVLHIIEKKPDGWWLAKDAEGVEGLIPRTYLEPYNKEDKLESSEGSEEGGEEDGEEDVEVVDETADGAQVKQRTDSHWSAVRKAISEQINTVDVLATMGAIPAGFRPSTLSQLLDEAGNQFRASYFLQPELTTSQLAFRDLTWDAKAGTIMSRPSRVSLILTLWSCKMIPLPGTSIQVLSRHIRLCLFDGSKVLSNIHTVRAVWQPKKPKTWTFSPQVTGILPCLLDGDCFIRSNSSTPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGVEVDPSVSRRAQGSVFRQMISVRRQPQLLVKLRSLNRRSRAMLSLLPETLVGSMCSAHLLIFYRQILGDVLLRDRTNLQSADLISHPVLATFPLLLEQPDVMDALRSSWSEKESTLKRAEKRDKELLKAEFLLVYHDCVLPLLHSTLLPPFRWAEEETEAARWKAIADFLKQSRENEGSLKALLSPDGVHKPFDLSEQTFDFLGEIRKNSG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | ELKLQVDSLVTESQL CHHHHHHHHCCHHHH | 26.36 | 27841257 | |
| 46 | Phosphorylation | PSKRREIYQRCIQLK HHHHHHHHHHHHHHH | 5.78 | - | |
| 78 | Phosphorylation | EAAPVGNYEQRKEEE HCCCCCCHHHHHHHH | 13.91 | 29514104 | |
| 137 | Phosphorylation | TGGEEEESEGDGEGK HCCCCCCCCCCCCCC | 50.59 | 25195567 | |
| 304 | Phosphorylation | GNQFRASYFLQPELT CHHHHHEEECCCCCC | 13.81 | - | |
| 649 | Phosphorylation | IADFLKQSRENEGSL HHHHHHHHHCCCCCH | 39.72 | - | |
| 661 | Phosphorylation | GSLKALLSPDGVHKP CCHHHHCCCCCCCCC | 23.07 | 25293948 | |
| 672 | Phosphorylation | VHKPFDLSEQTFDFL CCCCCCCCHHHHHHH | 29.51 | 25293948 | |
| 675 | Phosphorylation | PFDLSEQTFDFLGEI CCCCCHHHHHHHHHH | 22.56 | 25293948 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NPHP1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NPHP1_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
