ALDR_MOUSE - dbPTM
ALDR_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALDR_MOUSE
UniProt AC P45376
Protein Name Aldose reductase
Gene Name Akr1b1
Organism Mus musculus (Mouse).
Sequence Length 316
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies..
Protein Sequence MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASHLELNN
------CCCCEECCC		12.98-
3Phosphorylation-----MASHLELNNG
-----CCCCEECCCC		27.5730352176
12UbiquitinationLELNNGTKMPTLGLG
EECCCCCCCCCCCCC		44.26-
15PhosphorylationNNGTKMPTLGLGTWK
CCCCCCCCCCCCCCC		29.9324759943
23PhosphorylationLGLGTWKSPPGQVTE
CCCCCCCCCCCCHHH		28.0828066266
29PhosphorylationKSPPGQVTEAVKVAI
CCCCCCHHHHHHHHH		15.4428464351
45S-nitrosocysteineLGYRHIDCAQVYQNE
CCCCEEEHHHHHCCH		2.56-
45S-nitrosylationLGYRHIDCAQVYQNE
CCCCEEEHHHHHCCH		2.5621278135
49PhosphorylationHIDCAQVYQNEKEVG
EEEHHHHHCCHHHHH		8.1122817900
53AcetylationAQVYQNEKEVGVALQ
HHHHCCHHHHHHHHH		66.3122826441
78AcetylationQDLFIVSKLWCTFHD
HCCEEEEEEECCCCC		34.8022826441
81S-nitrosocysteineFIVSKLWCTFHDKSM
EEEEEEECCCCCHHH		4.17-
81S-nitrosylationFIVSKLWCTFHDKSM
EEEEEEECCCCCHHH		4.1721278135
95AcetylationMVKGAFQKTLSDLQL
HHHHHHHHHHHHHCC		45.00-
179AcetylationNKPGLKYKPAVNQIE
CCCCCCCCCCCCEEE		25.5522826441
179UbiquitinationNKPGLKYKPAVNQIE
CCCCCCCCCCCCEEE		25.55-
187GlutathionylationPAVNQIECHPYLTQE
CCCCEEECCCCCCHH		4.1224333276
187S-nitrosylationPAVNQIECHPYLTQE
CCCCEEECCCCCCHH		4.1221278135
187S-nitrosocysteinePAVNQIECHPYLTQE
CCCCEEECCCCCCHH		4.12-
195AcetylationHPYLTQEKLIEYCHS
CCCCCHHHHHHHHHH		44.9722826441
208PhosphorylationHSKGIVVTAYSPLGS
HHCCEEEEEECCCCC		14.6926643407
210PhosphorylationKGIVVTAYSPLGSPD
CCEEEEEECCCCCCC		11.0626643407
211PhosphorylationGIVVTAYSPLGSPDR
CEEEEEECCCCCCCC		15.9326643407
215PhosphorylationTAYSPLGSPDRPWAK
EEECCCCCCCCCCCC		31.1726643407
222AcetylationSPDRPWAKPEDPSLL
CCCCCCCCCCCCCHH		45.1023236377
222UbiquitinationSPDRPWAKPEDPSLL
CCCCCCCCCCCCCHH		45.10-
227PhosphorylationWAKPEDPSLLEDPRI
CCCCCCCCHHCCHHH		58.8921082442
240AcetylationRIKAIAAKYNKTTAQ
HHHHHHHHCCCCCHH		40.0922826441
243AcetylationAIAAKYNKTTAQVLI
HHHHHCCCCCHHHHE		44.1322826441
263AcetylationRNLVVIPKSVTPVRI
CCEEEECCCCCCEEE		46.5722826441
263UbiquitinationRNLVVIPKSVTPVRI
CCEEEECCCCCCEEE		46.57-
264PhosphorylationNLVVIPKSVTPVRIA
CEEEECCCCCCEEEE		26.3525266776
266PhosphorylationVVIPKSVTPVRIAEN
EEECCCCCCEEEECC		24.1325266776
299GlutathionylationYNRNWRVCALMSCAK
CCCCCEEHHHHHHHH		1.4824333276
304S-nitrosylationRVCALMSCAKHKDYP
EEHHHHHHHHCCCCC		3.4920925432
304S-nitrosocysteineRVCALMSCAKHKDYP
EEHHHHHHHHCCCCC		3.49-
306AcetylationCALMSCAKHKDYPFH
HHHHHHHHCCCCCCC		56.3622826441
308AcetylationLMSCAKHKDYPFHAE
HHHHHHCCCCCCCCC		59.2422826441
310PhosphorylationSCAKHKDYPFHAEV-
HHHHCCCCCCCCCC-		16.7629514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALDR_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALDR_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALDR_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ALDR_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALDR_MOUSE

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Related Literatures of Post-Translational Modification

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