ALBU_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALBU_MOUSE
• UniProt AC: P07724
• Protein Name: Serum albumin
• Gene Name: Alb
• Organism: Mus musculus (Mouse).
• Sequence Length: 608
• Subcellular Localization: Secreted.
• Protein Description: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc..
• Protein Sequence: MKWVTFLLLLFVSGSAFSRGVFRREAHKSEIAHRYNDLGEQHFKGLVLIAFSQYLQKCSYDEHAKLVQEVTDFAKTCVADESAANCDKSLHTLFGDKLCAIPNLRENYGELADCCTKQEPERNECFLQHKDDNPSLPPFERPEAEAMCTSFKENPTTFMGHYLHEVARRHPYFYAPELLYYAEQYNEILTQCCAEADKESCLTPKLDGVKEKALVSSVRQRMKCSSMQKFGERAFKAWAVARLSQTFPNADFAEITKLATDLTKVNKECCHGDLLECADDRAELAKYMCENQATISSKLQTCCDKPLLKKAHCLSEVEHDTMPADLPAIAADFVEDQEVCKNYAEAKDVFLGTFLYEYSRRHPDYSVSLLLRLAKKYEATLEKCCAEANPPACYGTVLAEFQPLVEEPKNLVKTNCDLYEKLGEYGFQNAILVRYTQKAPQVSTPTLVEAARNLGRVGTKCCTLPEDQRLPCVEDYLSAILNRVCLLHEKTPVSEHVTKCCSGSLVERRPCFSALTVDETYVPKEFKAETFTFHSDICTLPEKEKQIKKQTALAELVKHKPKATAEQLKTVMDDFAQFLDTCCKAADKDTCFSTEGPNLVTRCKDALA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LLLFVSGSAFSRGVF HHHHHCCCHHHCCCC	20.73	51459279
18	Phosphorylation	FVSGSAFSRGVFRRE HHCCCHHHCCCCCHH	28.04	46161845
28	Acetylation	VFRREAHKSEIAHRY CCCHHHHHHHHHHHH	57.75	23576753
29	Phosphorylation	FRREAHKSEIAHRYN CCHHHHHHHHHHHHC	25.11	51459271
35	Phosphorylation	KSEIAHRYNDLGEQH HHHHHHHHCHHCHHH	11.80	25195567
44	Acetylation	DLGEQHFKGLVLIAF HHCHHHHCHHHHHHH	49.57	7609767
52	Phosphorylation	GLVLIAFSQYLQKCS HHHHHHHHHHHHHCC	14.64	27180971
58	S-palmitoylation	FSQYLQKCSYDEHAK HHHHHHHCCHHHHHH	2.69	26165157
60	Nitration	QYLQKCSYDEHAKLV HHHHHCCHHHHHHHH	34.52	-
60	Phosphorylation	QYLQKCSYDEHAKLV HHHHHCCHHHHHHHH	34.52	15534371
65	Ubiquitination	CSYDEHAKLVQEVTD CCHHHHHHHHHHHHH	51.61	22790023
75	Acetylation	QEVTDFAKTCVADES HHHHHHHHHHHCCHH	42.31	21728379
82	Phosphorylation	KTCVADESAANCDKS HHHHCCHHHHCCCCH	32.98	-
88	Acetylation	ESAANCDKSLHTLFG HHHHCCCCHHHHHHH	58.05	7923455
88	Ubiquitination	ESAANCDKSLHTLFG HHHHCCCCHHHHHHH	58.05	22790023
89	Phosphorylation	SAANCDKSLHTLFGD HHHCCCCHHHHHHHH	16.48	23984901
92	Phosphorylation	NCDKSLHTLFGDKLC CCCCHHHHHHHHHHC	29.13	23984901
97	Ubiquitination	LHTLFGDKLCAIPNL HHHHHHHHHCCCCCH	45.93	22790023
99	S-palmitoylation	TLFGDKLCAIPNLRE HHHHHHHCCCCCHHH	3.88	28526873
114	S-palmitoylation	NYGELADCCTKQEPE HCHHHHHHCCCCCCC	2.36	28526873
115	S-palmitoylation	YGELADCCTKQEPER CHHHHHHCCCCCCCC	5.69	28526873
148	S-palmitoylation	RPEAEAMCTSFKENP CHHHHHHHHHCCCCC	3.57	28526873
150	Phosphorylation	EAEAMCTSFKENPTT HHHHHHHHCCCCCCC	29.41	21183079
203	Phosphorylation	ADKESCLTPKLDGVK CCHHHCCCCCCCCHH	23.78	59148729
205	Ubiquitination	KESCLTPKLDGVKEK HHHCCCCCCCCHHHH	54.71	22790023
210	Succinylation	TPKLDGVKEKALVSS CCCCCCHHHHHHHHH	60.05	23954790
212	Succinylation	KLDGVKEKALVSSVR CCCCHHHHHHHHHHH	41.10	23954790
212	Ubiquitination	KLDGVKEKALVSSVR CCCCHHHHHHHHHHH	41.10	-
216	Phosphorylation	VKEKALVSSVRQRMK HHHHHHHHHHHHHHC	24.78	24719451
223	Acetylation	SSVRQRMKCSSMQKF HHHHHHHCCHHHHHH	32.90	23806337
223	Succinylation	SSVRQRMKCSSMQKF HHHHHHHCCHHHHHH	32.90	23806337
229	Acetylation	MKCSSMQKFGERAFK HCCHHHHHHHHHHHH	46.85	21728379
229	Succinylation	MKCSSMQKFGERAFK HCCHHHHHHHHHHHH	46.85	-
229	Succinylation	MKCSSMQKFGERAFK HCCHHHHHHHHHHHH	46.85	23806337
236	Acetylation	KFGERAFKAWAVARL HHHHHHHHHHHHHHH	41.87	21728379
236	Phosphoglycerylation	KFGERAFKAWAVARL HHHHHHHHHHHHHHH	41.87	-
236	Succinylation	KFGERAFKAWAVARL HHHHHHHHHHHHHHH	41.87	23954790
236	Ubiquitination	KFGERAFKAWAVARL HHHHHHHHHHHHHHH	41.87	-
244	Phosphorylation	AWAVARLSQTFPNAD HHHHHHHHCCCCCCC	22.94	27180971
246	Phosphorylation	AVARLSQTFPNADFA HHHHHHCCCCCCCHH	37.37	23984901
257	Ubiquitination	ADFAEITKLATDLTK CCHHHHHHHHHHHHH	41.61	22790023
260	Phosphorylation	AEITKLATDLTKVNK HHHHHHHHHHHHHCH	41.81	27180971
264	Acetylation	KLATDLTKVNKECCH HHHHHHHHHCHHHCC	51.62	23954790
264	Succinylation	KLATDLTKVNKECCH HHHHHHHHHCHHHCC	51.62	23954790
264	Ubiquitination	KLATDLTKVNKECCH HHHHHHHHHCHHHCC	51.62	-
267	Acetylation	TDLTKVNKECCHGDL HHHHHHCHHHCCCCH	55.93	23201123
267	Malonylation	TDLTKVNKECCHGDL HHHHHHCHHHCCCCH	55.93	26073543
269	S-nitrosylation	LTKVNKECCHGDLLE HHHHCHHHCCCCHHH	1.91	22588120
269	S-palmitoylation	LTKVNKECCHGDLLE HHHHCHHHCCCCHHH	1.91	28526873
270	S-nitrosylation	TKVNKECCHGDLLEC HHHCHHHCCCCHHHH	4.16	22588120
270	S-palmitoylation	TKVNKECCHGDLLEC HHHCHHHCCCCHHHH	4.16	28526873
277	S-nitrosylation	CHGDLLECADDRAEL CCCCHHHHCCCHHHH	5.19	22588120
277	S-palmitoylation	CHGDLLECADDRAEL CCCCHHHHCCCHHHH	5.19	28526873
287	Phosphorylation	DRAELAKYMCENQAT CHHHHHHHHHHCCCC	11.03	27742792
289	S-palmitoylation	AELAKYMCENQATIS HHHHHHHHHCCCCHH	3.94	28526873
294	Phosphorylation	YMCENQATISSKLQT HHHHCCCCHHHHHHH	16.19	51459287
297	Phosphorylation	ENQATISSKLQTCCD HCCCCHHHHHHHHCC	33.27	22817900
301	Phosphorylation	TISSKLQTCCDKPLL CHHHHHHHHCCCHHH	26.07	22817900
302	S-nitrosylation	ISSKLQTCCDKPLLK HHHHHHHHCCCHHHH	1.50	22588120
302	S-palmitoylation	ISSKLQTCCDKPLLK HHHHHHHHCCCHHHH	1.50	26165157
303	S-nitrosylation	SSKLQTCCDKPLLKK HHHHHHHCCCHHHHH	9.52	22588120
305	Acetylation	KLQTCCDKPLLKKAH HHHHHCCCHHHHHHH	24.53	21728379
305	Malonylation	KLQTCCDKPLLKKAH HHHHHCCCHHHHHHH	24.53	26073543
305	Ubiquitination	KLQTCCDKPLLKKAH HHHHHCCCHHHHHHH	24.53	-
309	Acetylation	CCDKPLLKKAHCLSE HCCCHHHHHHHHHHH	56.44	23201123
315	Phosphorylation	LKKAHCLSEVEHDTM HHHHHHHHHCCCCCC	45.02	22817900
359	Phosphorylation	GTFLYEYSRRHPDYS HHHHHHHHHHCCCCC	15.76	24719451
360	Dimethylation	TFLYEYSRRHPDYSV HHHHHHHHHCCCCCH	39.77	-
361	Dimethylation	FLYEYSRRHPDYSVS HHHHHHHHCCCCCHH	39.49	-
365	Nitration	YSRRHPDYSVSLLLR HHHHCCCCCHHHHHH	18.54	-
365	Phosphorylation	YSRRHPDYSVSLLLR HHHHCCCCCHHHHHH	18.54	27180971
366	Phosphorylation	SRRHPDYSVSLLLRL HHHCCCCCHHHHHHH	16.77	21183079
368	Phosphorylation	RHPDYSVSLLLRLAK HCCCCCHHHHHHHHH	13.83	27180971
376	Acetylation	LLLRLAKKYEATLEK HHHHHHHHHHHHHHH	42.59	23954790
376	Ubiquitination	LLLRLAKKYEATLEK HHHHHHHHHHHHHHH	42.59	22790023
384	S-nitrosylation	YEATLEKCCAEANPP HHHHHHHHHHHCCCC	1.62	22588120
385	S-nitrosylation	EATLEKCCAEANPPA HHHHHHHHHHCCCCC	5.93	22588120
393	S-nitrosylation	AEANPPACYGTVLAE HHCCCCCEEHHHHHH	3.87	22588120
413	Ubiquitination	EEPKNLVKTNCDLYE CCCHHHHHCCCHHHH	36.87	22790023
416	S-palmitoylation	KNLVKTNCDLYEKLG HHHHHCCCHHHHHHH	4.64	28526873
421	Acetylation	TNCDLYEKLGEYGFQ CCCHHHHHHHHHCCC	48.51	22902405
425	Nitration	LYEKLGEYGFQNAIL HHHHHHHHCCCCEEE	22.80	-
425	Phosphorylation	LYEKLGEYGFQNAIL HHHHHHHHCCCCEEE	22.80	27180971
438	Succinylation	ILVRYTQKAPQVSTP EEEEECCCCCCCCCH	54.99	23954790
438	Ubiquitination	ILVRYTQKAPQVSTP EEEEECCCCCCCCCH	54.99	-
443	Phosphorylation	TQKAPQVSTPTLVEA CCCCCCCCCHHHHHH	24.34	22817900
444	Phosphorylation	QKAPQVSTPTLVEAA CCCCCCCCHHHHHHH	22.80	28318527
446	Phosphorylation	APQVSTPTLVEAARN CCCCCCHHHHHHHHH	43.45	-
460	Acetylation	NLGRVGTKCCTLPED HHCCCCCCCCCCCHH	22.76	23806337
460	Succinylation	NLGRVGTKCCTLPED HHCCCCCCCCCCCHH	22.76	-
460	Succinylation	NLGRVGTKCCTLPED HHCCCCCCCCCCCHH	22.76	23806337
460	Ubiquitination	NLGRVGTKCCTLPED HHCCCCCCCCCCCHH	22.76	-
461	S-palmitoylation	LGRVGTKCCTLPEDQ HCCCCCCCCCCCHHH	1.84	26165157
463	Phosphorylation	RVGTKCCTLPEDQRL CCCCCCCCCCHHHCC	55.61	24719451
472	S-nitrosylation	PEDQRLPCVEDYLSA CHHHCCCCHHHHHHH	6.57	22588120
472	S-palmitoylation	PEDQRLPCVEDYLSA CHHHCCCCHHHHHHH	6.57	28526873
490	Acetylation	RVCLLHEKTPVSEHV HHHHHCCCCCCCHHH	47.59	7611599
490	Ubiquitination	RVCLLHEKTPVSEHV HHHHHCCCCCCCHHH	47.59	22790023
491	Phosphorylation	VCLLHEKTPVSEHVT HHHHCCCCCCCHHHH	26.41	23375375
494	Phosphorylation	LHEKTPVSEHVTKCC HCCCCCCCHHHHHHC	24.16	28542873
499	Acetylation	PVSEHVTKCCSGSLV CCCHHHHHHCCCCHH	31.96	68447
499	Ubiquitination	PVSEHVTKCCSGSLV CCCHHHHHHCCCCHH	31.96	22790023
500	S-nitrosylation	VSEHVTKCCSGSLVE CCHHHHHHCCCCHHH	1.31	22588120
500	S-palmitoylation	VSEHVTKCCSGSLVE CCHHHHHHCCCCHHH	1.31	28526873
501	S-nitrosylation	SEHVTKCCSGSLVER CHHHHHHCCCCHHHC	5.71	22588120
501	S-palmitoylation	SEHVTKCCSGSLVER CHHHHHHCCCCHHHC	5.71	28526873
502	Phosphorylation	EHVTKCCSGSLVERR HHHHHHCCCCHHHCC	40.67	24719451
511	S-nitrosylation	SLVERRPCFSALTVD CHHHCCCCCCEEEEC	3.90	22588120
511	S-palmitoylation	SLVERRPCFSALTVD CHHHCCCCCCEEEEC	3.90	28526873
513	Phosphorylation	VERRPCFSALTVDET HHCCCCCCEEEECCC	29.14	-
520	Phosphorylation	SALTVDETYVPKEFK CEEEECCCCCCCCCC	25.92	23882026
521	Phosphorylation	ALTVDETYVPKEFKA EEEECCCCCCCCCCC	16.83	26026062
524	Acetylation	VDETYVPKEFKAETF ECCCCCCCCCCCCEE	66.78	21728379
535	Phosphorylation	AETFTFHSDICTLPE CCEEEEECCCCCCCH	25.20	51459295
538	S-nitrosylation	FTFHSDICTLPEKEK EEEECCCCCCCHHHH	3.72	22588120
538	S-palmitoylation	FTFHSDICTLPEKEK EEEECCCCCCCHHHH	3.72	28526873
543	Acetylation	DICTLPEKEKQIKKQ CCCCCCHHHHHHHHH	69.17	23806337
543	Succinylation	DICTLPEKEKQIKKQ CCCCCCHHHHHHHHH	69.17	-
543	Succinylation	DICTLPEKEKQIKKQ CCCCCCHHHHHHHHH	69.17	23806337
549	Ubiquitination	EKEKQIKKQTALAEL HHHHHHHHHHHHHHH	55.28	22790023
551	Phosphorylation	EKQIKKQTALAELVK HHHHHHHHHHHHHHH	32.30	27180971
558	Acetylation	TALAELVKHKPKATA HHHHHHHHCCCCCCH	59.54	23954790
558	Methylation	TALAELVKHKPKATA HHHHHHHHCCCCCCH	59.54	-
570	Phosphorylation	ATAEQLKTVMDDFAQ CCHHHHHHHHHHHHH	29.65	24719451
582	S-palmitoylation	FAQFLDTCCKAADKD HHHHHHHHHHHCCCC	1.93	28526873
583	S-palmitoylation	AQFLDTCCKAADKDT HHHHHHHHHHCCCCC	3.50	28526873
588	Acetylation	TCCKAADKDTCFSTE HHHHHCCCCCCCCCC	50.65	23806337
588	Malonylation	TCCKAADKDTCFSTE HHHHHCCCCCCCCCC	50.65	25418362
588	Succinylation	TCCKAADKDTCFSTE HHHHHCCCCCCCCCC	50.65	-
588	Succinylation	TCCKAADKDTCFSTE HHHHHCCCCCCCCCC	50.65	23806337
590	Phosphorylation	CKAADKDTCFSTEGP HHHCCCCCCCCCCCC	22.61	23984901
591	S-nitrosylation	KAADKDTCFSTEGPN HHCCCCCCCCCCCCC	3.48	22588120
591	S-palmitoylation	KAADKDTCFSTEGPN HHCCCCCCCCCCCCC	3.48	28526873
593	Phosphorylation	ADKDTCFSTEGPNLV CCCCCCCCCCCCCHH	27.91	25521595
594	Phosphorylation	DKDTCFSTEGPNLVT CCCCCCCCCCCCHHH	25.39	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALBU_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALBU_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALBU_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ALBU_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.