ALBU_BOVIN - dbPTM
ALBU_BOVIN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALBU_BOVIN
UniProt AC P02769
Protein Name Serum albumin
Gene Name ALB
Organism Bos taurus (Bovine).
Sequence Length 607
Subcellular Localization Secreted.
Protein Description Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc..
Protein Sequence MKWVTFISLLLLFSSAYSRGVFRRDTHKSEIAHRFKDLGEEHFKGLVLIAFSQYLQQCPFDEHVKLVNELTEFAKTCVADESHAGCEKSLHTLFGDELCKVASLRETYGDMADCCEKQEPERNECFLSHKDDSPDLPKLKPDPNTLCDEFKADEKKFWGKYLYEIARRHPYFYAPELLYYANKYNGVFQECCQAEDKGACLLPKIETMREKVLASSARQRLRCASIQKFGERALKAWSVARLSQKFPKAEFVEVTKLVTDLTKVHKECCHGDLLECADDRADLAKYICDNQDTISSKLKECCDKPLLEKSHCIAEVEKDAIPENLPPLTADFAEDKDVCKNYQEAKDAFLGSFLYEYSRRHPEYAVSVLLRLAKEYEATLEECCAKDDPHACYSTVFDKLKHLVDEPQNLIKQNCDQFEKLGEYGFQNALIVRYTRKVPQVSTPTLVEVSRSLGKVGTRCCTKPESERMPCTEDYLSLILNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYVPKAFDEKLFTFHADICTLPDTEKQIKKQTALVELLKHKPKATEEQLKTVMENFVAFVDKCCAADDKEACFAVEGPKLVVSTQTALA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28GlycationVFRRDTHKSEIAHRF
CCCCCCCHHHHHHHH		52.45-
29PhosphorylationFRRDTHKSEIAHRFK
CCCCCCHHHHHHHHH		26.99-
36GlycationSEIAHRFKDLGEEHF
HHHHHHHHHHCHHHH		52.58-
54NitrationVLIAFSQYLQQCPFD
HHHHHHHHHHHCCCH		12.79-
58S-nitrosocysteineFSQYLQQCPFDEHVK
HHHHHHHCCCHHHHH		2.03-
58GlutathionylationFSQYLQQCPFDEHVK
HHHHHHHCCCHHHHH		2.0324333276
58S-nitrosylationFSQYLQQCPFDEHVK
HHHHHHHCCCHHHHH		2.0317135341
75GlycationNELTEFAKTCVADES
HHHHHHHHHHHHCCC		48.02-
77GlutathionylationLTEFAKTCVADESHA
HHHHHHHHHHCCCCC		2.0424333276
82PhosphorylationKTCVADESHAGCEKS
HHHHHCCCCCCCCHH		21.1329541418
86GlutathionylationADESHAGCEKSLHTL
HCCCCCCCCHHHHHH		6.5424333276
88GlycationESHAGCEKSLHTLFG
CCCCCCCHHHHHHHH		63.49-
89PhosphorylationSHAGCEKSLHTLFGD
CCCCCCHHHHHHHHH		11.77-
99GlutathionylationTLFGDELCKVASLRE
HHHHHHHHHHHHHHH		2.9124333276
100GlycationLFGDELCKVASLRET
HHHHHHHHHHHHHHH		54.16-
107PhosphorylationKVASLRETYGDMADC
HHHHHHHHHHCHHHH		26.77-
108NitrationVASLRETYGDMADCC
HHHHHHHHHCHHHHH		13.33-
117GlycationDMADCCEKQEPERNE
CHHHHHHHCCCCCCC		46.15-
125GlutathionylationQEPERNECFLSHKDD
CCCCCCCCCCCCCCC		4.8024333276
130GlycationNECFLSHKDDSPDLP
CCCCCCCCCCCCCCC		60.91-
147GlutathionylationKPDPNTLCDEFKADE
CCCCCCCCHHHHCCH		4.4224333276
151GlycationNTLCDEFKADEKKFW
CCCCHHHHCCHHHHH		53.53-
151N-linked_GlycosylationNTLCDEFKADEKKFW
CCCCHHHHCCHHHHH		53.5321565706
156GlycationEFKADEKKFWGKYLY
HHHCCHHHHHHHHHH		44.28-
160GlycationDEKKFWGKYLYEIAR
CHHHHHHHHHHHHHH		23.76-
161NitrationEKKFWGKYLYEIARR
HHHHHHHHHHHHHHH		15.58-
163NitrationKFWGKYLYEIARRHP
HHHHHHHHHHHHHCC		11.38-
171NitrationEIARRHPYFYAPELL
HHHHHCCCCCHHHHH		11.78-
173NitrationARRHPYFYAPELLYY
HHHCCCCCHHHHHHH		18.53-
179NitrationFYAPELLYYANKYNG
CCHHHHHHHHHHHCC		17.10-
180NitrationYAPELLYYANKYNGV
CHHHHHHHHHHHCCH		12.03-
183GlycationELLYYANKYNGVFQE
HHHHHHHHHCCHHHH		31.74-
184NitrationLLYYANKYNGVFQEC
HHHHHHHHCCHHHHH		19.56-
204GlycationKGACLLPKIETMREK
CCCCCHHHHHHHHHH		53.82-
223GlutathionylationSARQRLRCASIQKFG
HHHHHHHHHHHHHHH		4.0524333276
228GlycationLRCASIQKFGERALK
HHHHHHHHHHHHHHH		54.38-
228SuccinylationLRCASIQKFGERALK
HHHHHHHHHHHHHHH		54.38-
228SuccinylationLRCASIQKFGERALK
HHHHHHHHHHHHHHH		54.38-
235AcetylationKFGERALKAWSVARL
HHHHHHHHHHHHHHH		46.99-
235GlycationKFGERALKAWSVARL
HHHHHHHHHHHHHHH		46.99-
248GlycationRLSQKFPKAEFVEVT
HHHCCCCHHHHHHHH		64.78-
256GlycationAEFVEVTKLVTDLTK
HHHHHHHHHHHHHHH		46.25-
263GlycationKLVTDLTKVHKECCH
HHHHHHHHHCHHHCC		50.03-
266GlycationTDLTKVHKECCHGDL
HHHHHHCHHHCCCCH		56.27-
276GlutathionylationCHGDLLECADDRADL
CCCCHHHCCCCHHHH		5.1924333276
285GlycationDDRADLAKYICDNQD
CCHHHHHHHHHCCCC		42.31-
286NitrationDRADLAKYICDNQDT
CHHHHHHHHHCCCCH		10.94-
288S-nitrosocysteineADLAKYICDNQDTIS
HHHHHHHHCCCCHHH		3.50-
288GlutathionylationADLAKYICDNQDTIS
HHHHHHHHCCCCHHH		3.5024333276
288S-nitrosylationADLAKYICDNQDTIS
HHHHHHHHCCCCHHH		3.5022178444
296PhosphorylationDNQDTISSKLKECCD
CCCCHHHHHHHHHCC		37.85-
297GlycationNQDTISSKLKECCDK
CCCHHHHHHHHHCCC		57.71-
299GlycationDTISSKLKECCDKPL
CHHHHHHHHHCCCHH		53.06-
302GlutathionylationSSKLKECCDKPLLEK
HHHHHHHCCCHHHHH		8.7024333276
309GlycationCDKPLLEKSHCIAEV
CCCHHHHHHHHHHHH		45.53-
312GlutathionylationPLLEKSHCIAEVEKD
HHHHHHHHHHHHHHC		3.9924333276
339GlutathionylationFAEDKDVCKNYQEAK
HHCCHHHHHHHHHHH		3.2024333276
342NitrationDKDVCKNYQEAKDAF
CHHHHHHHHHHHHHH		8.01-
346GlycationCKNYQEAKDAFLGSF
HHHHHHHHHHHHHHH		49.16-
355NitrationAFLGSFLYEYSRRHP
HHHHHHHHHHHHHCH		15.71-
357NitrationLGSFLYEYSRRHPEY
HHHHHHHHHHHCHHH		8.23-
374GlycationSVLLRLAKEYEATLE
HHHHHHHHHHHHHHH		66.48-
376NitrationLLRLAKEYEATLEEC
HHHHHHHHHHHHHHH		15.34-
392S-nitrosocysteineAKDDPHACYSTVFDK
HCCCCCCCHHHHHHH		2.22-
392S-nitrosylationAKDDPHACYSTVFDK
HCCCCCCCHHHHHHH		2.2222178444
393NitrationKDDPHACYSTVFDKL
CCCCCCCHHHHHHHH		14.25-
399GlycationCYSTVFDKLKHLVDE
CHHHHHHHHHHHCCC		48.23-
401GlycationSTVFDKLKHLVDEPQ
HHHHHHHHHHCCCHH		40.40-
412GlycationDEPQNLIKQNCDQFE
CCHHHHHHHCHHHHH		38.33-
415GlutathionylationQNLIKQNCDQFEKLG
HHHHHHCHHHHHHHH		3.9424333276
420GlycationQNCDQFEKLGEYGFQ
HCHHHHHHHHHHHCC		64.18-
434NitrationQNALIVRYTRKVPQV
CCEEEEEECCCCCCC		10.45-
437AcetylationLIVRYTRKVPQVSTP
EEEEECCCCCCCCCC		50.93-
437GlycationLIVRYTRKVPQVSTP
EEEEECCCCCCCCCC		50.93-
442PhosphorylationTRKVPQVSTPTLVEV
CCCCCCCCCCCHHHH		24.34-
443PhosphorylationRKVPQVSTPTLVEVS
CCCCCCCCCCHHHHH		22.80-
445PhosphorylationVPQVSTPTLVEVSRS
CCCCCCCCHHHHHHH		43.45-
450PhosphorylationTPTLVEVSRSLGKVG
CCCHHHHHHHHCCCC		11.5729541418
455GlycationEVSRSLGKVGTRCCT
HHHHHHCCCCCCCCC		42.66-
460GlutathionylationLGKVGTRCCTKPESE
HCCCCCCCCCCCHHH		3.2924333276
461GlutathionylationGKVGTRCCTKPESER
CCCCCCCCCCCHHHC		5.0324333276
471S-nitrosocysteinePESERMPCTEDYLSL
CHHHCCCCCHHHHHH		4.81-
471GlutathionylationPESERMPCTEDYLSL
CHHHCCCCCHHHHHH		4.8124333276
471S-nitrosylationPESERMPCTEDYLSL
CHHHCCCCCHHHHHH		4.8122178444
475NitrationRMPCTEDYLSLILNR
CCCCCHHHHHHHHHH		7.61-
484GlutathionylationSLILNRLCVLHEKTP
HHHHHHHHHHCCCCC		2.5024333276
489GlycationRLCVLHEKTPVSEKV
HHHHHCCCCCCCHHH		47.59-
495GlycationEKTPVSEKVTKCCTE
CCCCCCHHHHHHHHH		47.93-
498GlycationPVSEKVTKCCTESLV
CCCHHHHHHHHHHHH		30.24-
500GlutathionylationSEKVTKCCTESLVNR
CHHHHHHHHHHHHHC		5.1524333276
510GlutathionylationSLVNRRPCFSALTPD
HHHHCCCCCCCCCCC		3.9024333276
512PhosphorylationVNRRPCFSALTPDET
HHCCCCCCCCCCCCC		29.14-
520NitrationALTPDETYVPKAFDE
CCCCCCCCCCCHHCC		16.83-
523GlycationPDETYVPKAFDEKLF
CCCCCCCCHHCCCCE		52.20-
528GlycationVPKAFDEKLFTFHAD
CCCHHCCCCEEEEEC		51.23-
537GlutathionylationFTFHADICTLPDTEK
EEEEECCCCCCCHHH		3.0924333276
548GlycationDTEKQIKKQTALVEL
CHHHHHHHHHHHHHH		55.28-
557MethylationTALVELLKHKPKATE
HHHHHHHHCCCCCCH		63.31-
561GlycationELLKHKPKATEEQLK
HHHHCCCCCCHHHHH		73.14-
568GlycationKATEEQLKTVMENFV
CCCHHHHHHHHHHHH		38.47-
569PhosphorylationATEEQLKTVMENFVA
CCHHHHHHHHHHHHH		33.41-
580GlycationNFVAFVDKCCAADDK
HHHHHHHHHHCCCCH		26.38-
587GlycationKCCAADDKEACFAVE
HHHCCCCHHHEEEEE		48.00-
587SuccinylationKCCAADDKEACFAVE
HHHCCCCHHHEEEEE		48.00-
587SuccinylationKCCAADDKEACFAVE
HHHCCCCHHHEEEEE		48.00-
590GlutathionylationAADDKEACFAVEGPK
CCCCHHHEEEEECCE		2.0624333276
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALBU_BOVIN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALBU_BOVIN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALBU_BOVIN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ALBU_BOVIN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALBU_BOVIN

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Related Literatures of Post-Translational Modification

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