FLNC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLNC_MOUSE
• UniProt AC: Q8VHX6
• Protein Name: Filamin-C
• Gene Name: Flnc
• Organism: Mus musculus (Mouse).
• Sequence Length: 2726
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fra
• Protein Description: Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers..
• Protein Sequence: MMNNSNYSDASGLGLVDEADEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVQNAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGAQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPVEADIDFDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIQPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIQNNADGTYHITYSPAFPGTYTITIKYGGHPIPKFPTRVHVQPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGQPIPGSPFRVPVKDVVDPGKVKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPSHDASKVRASGPGLNASGIPASLPVEFTIDARDAGQGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHVEEPAEMLQMRQPYAPLRPGTCPTHWATEEPVVPVEPLESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MMNNSNYSDASG ---CCCCCCCCCCCC	31.94	25338131
7	Phosphorylation	-MMNNSNYSDASGLG -CCCCCCCCCCCCCC	14.03	29514104
36	Acetylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	7668579
37	Ubiquitination	AEDAPWKKIQQNTFT HHCCCHHHHHHHHHH	41.71	-
42	Phosphorylation	WKKIQQNTFTRWCNE HHHHHHHHHHHHHHH	23.26	25338131
59	Phosphorylation	KCVGKRLTDLQRDLS HHHHHHHHHHHHHHH	38.40	25338131
81	Acetylation	LLEVLSQKRMYRKFH HHHHHHHHCHHHHHC	35.44	22826441
114	Acetylation	FLEREHIKLVSIDSK HHHHCCEEEEEECCH	44.75	23236377
117	Phosphorylation	REHIKLVSIDSKAIV HCCEEEEEECCHHHH	30.99	25338131
380	Phosphorylation	LGDANKVSARGPGLE CCCCCCCCCCCCCCC	17.54	28464351
424	Phosphorylation	DPQGRRDTVEVALED CCCCCCCEEEEEEEE	19.43	26824392
463	Phosphorylation	AGAPITRSPFPVHVA ECCCCCCCCCCCHHH	23.42	26824392
499	Acetylation	VKEVADFKVFTKGAG EEEEEEEEEEECCCC	36.67	23236377
503	Acetylation	ADFKVFTKGAGSGEL EEEEEEECCCCCCEE	34.99	22826441
513	Phosphorylation	GSGELKVTVKGPKGT CCCEEEEEEECCCCC	18.21	24759943
560	Phosphorylation	GGYAIPRSPFEVQVS CCEECCCCCCEEEEC	28.69	27742792
567	Phosphorylation	SPFEVQVSPEAGAQK CCCEEEECHHHCCCE	10.42	28464351
574	Acetylation	SPEAGAQKVRAWGPG CHHHCCCEEEEECCC	32.90	23806337
574	Succinylation	SPEAGAQKVRAWGPG CHHHCCCEEEEECCC	32.90	23806337
626	Phosphorylation	CDDKGDGSCDVRYWP ECCCCCCCCEEEEEC	16.34	26824392
713	S-nitrosocysteine	YAQDADGCPIDIKVI EEECCCCCEEEEEEE	2.48	-
713	S-nitrosylation	YAQDADGCPIDIKVI EEECCCCCEEEEEEE	2.48	21278135
729	S-nitrosocysteine	NGDGTFRCSYVPTKP CCCCEEEEEECCCCC	2.76	-
729	S-nitrosylation	NGDGTFRCSYVPTKP CCCCEEEEEECCCCC	2.76	20925432
735	Acetylation	RCSYVPTKPIKHTII EEEECCCCCCCEEEE	38.38	23806337
753	Phosphorylation	GGVNVPKSPFRVNVG CCCCCCCCCCEEECC	24.17	26824392
777	Acetylation	VYGPGVEKTGLKANE EECCCCCCCCCCCCC	45.55	23236377
777	Ubiquitination	VYGPGVEKTGLKANE EECCCCCCCCCCCCC	45.55	-
856	Phosphorylation	ANQEIPASPFHIKVD ECCCCCCCCCEEEEC	23.81	26824392
872	Ubiquitination	SHDASKVKAEGPGLS CCCHHHCCCCCCCCC	44.44	-
879	Phosphorylation	KAEGPGLSRTGVEVG CCCCCCCCCCCCCCC	33.44	28464351
881	Phosphorylation	EGPGLSRTGVEVGKP CCCCCCCCCCCCCCC	42.05	22210690
887	Acetylation	RTGVEVGKPTHFTVL CCCCCCCCCCEEEEE	52.50	23806337
955	Phosphorylation	GGDPVPKSPFVVNVA CCCCCCCCCEEEEEC	19.94	27180971
969	Acetylation	APPLDLSKVKVQGLN CCCCCHHHCEEECCC	54.06	23236377
977	Phosphorylation	VKVQGLNSKVAVGQE CEEECCCCEEECCCC	33.28	29514104
1003	Methylation	GQGQLDVRMTSPSRR CCCCEEEEECCCCCC	23.48	24129315
1005	Phosphorylation	GQLDVRMTSPSRRPI CCEEEEECCCCCCCC	27.24	28973931
1006	Phosphorylation	QLDVRMTSPSRRPIP CEEEEECCCCCCCCC	16.13	26824392
1008	Phosphorylation	DVRMTSPSRRPIPCK EEEECCCCCCCCCCE	40.46	28973931
1015	Acetylation	SRRPIPCKLEPGGGA CCCCCCCEECCCCCC	51.00	23236377
1015	Ubiquitination	SRRPIPCKLEPGGGA CCCCCCCEECCCCCC	51.00	-
1051	Phosphorylation	DGHPVPGSPFAVEGV CCEECCCCCEEEEEE	15.69	26824392
1069	Phosphorylation	DPSKVCAYGPGLKGG CHHHCEECCCCCCCC	20.80	25263469
1080	Phosphorylation	LKGGLVGTPAPFSID CCCCCCCCCCCCEEE	14.59	26824392
1162	Phosphorylation	DPSKVRASGPGLERG CHHHCCCCCCCCCCC	34.65	28464351
1251	Phosphorylation	HVQPAVDTSGIKVSG EEECCCCCCCCEEEC	23.43	28464351
1252	Phosphorylation	VQPAVDTSGIKVSGP EECCCCCCCCEEECC	33.77	28464351
1257	Phosphorylation	DTSGIKVSGPGVEPH CCCCCEEECCCCCCC	33.98	24899341
1280	Phosphorylation	EFTVDARSLTATGGN EEEEECCEEEECCCC	31.62	26824392
1284	Phosphorylation	DARSLTATGGNHVTA ECCEEEECCCCEEEE	40.15	28464351
1297	Phosphorylation	TARVLNPSGAKTDTY EEEEECCCCCCCCEE	50.76	-
1300	Ubiquitination	VLNPSGAKTDTYVTD EECCCCCCCCEEEEE	50.92	-
1339	Phosphorylation	DEVAVPKSPFRVGVT CCCCCCCCCCCEECC	24.17	26824392
1349	S-nitrosocysteine	RVGVTEGCDPTRVRA CEECCCCCCCCCEEE	4.63	-
1349	S-nitrosylation	RVGVTEGCDPTRVRA CEECCCCCCCCCEEE	4.63	20925432
1352	Phosphorylation	VTEGCDPTRVRAFGP CCCCCCCCCEEEECC	28.66	23567750
1368	Ubiquitination	LEGGLVNKANRFTVE CCCCCCCCCCCEEEE	39.29	-
1450	Phosphorylation	DPGKVKCSGPGLGTG CCCCEECCCCCCCCC	42.16	28464351
1528	Phosphorylation	ADQEVPRSPFKIKVL CCCCCCCCCCEEEEC	28.72	26824392
1531	Ubiquitination	EVPRSPFKIKVLPSH CCCCCCCEEEECCCC	45.03	-
1533	Ubiquitination	PRSPFKIKVLPSHDA CCCCCEEEECCCCCH	38.01	-
1537	Phosphorylation	FKIKVLPSHDASKVR CEEEECCCCCHHHCC	29.82	28542873
1541	Phosphorylation	VLPSHDASKVRASGP ECCCCCHHHCCCCCC	37.43	29514104
1624	Phosphorylation	YGGDEIPYSPFRIHA ECCEECCCCCEEEEE	34.34	27742792
1625	Phosphorylation	GGDEIPYSPFRIHAL CCEECCCCCEEEEEE	16.53	26824392
1634	Phosphorylation	FRIHALPTGDASKCL EEEEEECCCCCCCEE	48.85	26824392
1729	Phosphorylation	GGEHIPNSPFHVLAC CCEECCCCCEEEEEC	24.48	21659605
1800	Phosphorylation	TVQKGELTGEVRMPS EEECCEEEEEEECCC	27.30	24899341
1816	Phosphorylation	KTARPNITDNKDGTI CCCCCCCCCCCCCCE	39.91	28464351
1832	Acetylation	VRYAPTEKGLHQMGI EEECCCCCCCCCCEE	70.06	23236377
1840	Acetylation	GLHQMGIKYDGNHIP CCCCCEEEECCCCCC	31.40	19859265
1849	Phosphorylation	DGNHIPGSPLQFYVD CCCCCCCCCEEEEHH	19.65	26824392
1854	Phosphorylation	PGSPLQFYVDAINSR CCCCEEEEHHHHHCC	5.62	28464351
1936	Acetylation	IIVRFDDKHIPGSPF EEEEECCCCCCCCCE	45.32	23236377
1936	Ubiquitination	IIVRFDDKHIPGSPF EEEEECCCCCCCCCE	45.32	-
1941	Phosphorylation	DDKHIPGSPFTAKIT CCCCCCCCCEEEEEC	16.10	26824392
1955	Phosphorylation	TGDDSMRTSQLNVGT CCCCCCCCCEECCCC	16.51	25338131
1962	Phosphorylation	TSQLNVGTSTDVSLK CCEECCCCCCCEEEE	24.95	28464351
1976	Phosphorylation	KITEGDLSQLTASIR EECCCCHHHHEEEEE	28.08	28464351
1979	Phosphorylation	EGDLSQLTASIRAPS CCCHHHHEEEEECCC	15.66	28464351
1981	Phosphorylation	DLSQLTASIRAPSGN CHHHHEEEEECCCCC	13.84	28464351
1986	Phosphorylation	TASIRAPSGNEEPCL EEEEECCCCCCCCCH	53.95	27742792
1992	S-nitrosocysteine	PSGNEEPCLLKRLPN CCCCCCCCHHHCCCC	8.65	-
1992	S-nitrosylation	PSGNEEPCLLKRLPN CCCCCCCCHHHCCCC	8.65	20925432
1995	Acetylation	NEEPCLLKRLPNRHI CCCCCHHHCCCCCCE	38.65	22826441
1995	Ubiquitination	NEEPCLLKRLPNRHI CCCCCHHHCCCCCCE	38.65	-
2005	Phosphorylation	PNRHIGISFTPKEVG CCCCEEEEECCHHHC	20.18	28542873
2007	Phosphorylation	RHIGISFTPKEVGEH CCEEEEECCHHHCCE	27.02	22817900
2017	Phosphorylation	EVGEHVVSVRKSGKH HHCCEEEEEECCCCC	18.34	27149854
2021	Phosphorylation	HVVSVRKSGKHVTNS EEEEEECCCCCCCCC	42.37	29514104
2023	Acetylation	VSVRKSGKHVTNSPF EEEECCCCCCCCCCC	41.83	23806337
2026	Phosphorylation	RKSGKHVTNSPFKIL ECCCCCCCCCCCEEE	29.69	25338131
2028	Phosphorylation	SGKHVTNSPFKILVG CCCCCCCCCCEEEEC	23.50	24899341
2031	Acetylation	HVTNSPFKILVGPSE CCCCCCCEEEECHHH	38.22	23236377
2037	Phosphorylation	FKILVGPSEIGDASK CEEEECHHHCCCHHH	35.60	28464351
2043	Phosphorylation	PSEIGDASKVRVWGK HHHCCCHHHEEEEEC	36.10	29514104
2100	Phosphorylation	EDGTCKVTYCPTEPG CCCEEEEEEECCCCC	12.61	28576409
2123	Phosphorylation	ADKHVPGSPFTVKVT CCCCCCCCCEEEEEE	15.69	24899341
2126	Phosphorylation	HVPGSPFTVKVTGEG CCCCCCEEEEEECCC	23.85	25168779
2138	Phosphorylation	GEGRMKESITRRRQA CCCCCCHHHHCCCCC	24.60	25338131
2147	Phosphorylation	TRRRQAPSIATIGST HCCCCCCCEEEECCC	28.06	27087446
2150	Phosphorylation	RQAPSIATIGSTCDL CCCCCEEEECCCCCE	24.97	29233185
2153	Phosphorylation	PSIATIGSTCDLNLK CCEEEECCCCCEEEE	23.24	26824392
2154	Phosphorylation	SIATIGSTCDLNLKI CEEEECCCCCEEEEC	12.58	29233185
2180	Phosphorylation	ERLTRTFTRSSHTYT HHHHCCCCCCCCCEE	29.09	-
2182	Phosphorylation	LTRTFTRSSHTYTRT HHCCCCCCCCCEEEE	24.34	27149854
2183	Phosphorylation	TRTFTRSSHTYTRTE HCCCCCCCCCEEEEE	19.29	29514104
2186	Phosphorylation	FTRSSHTYTRTERTE CCCCCCCEEEEEEEE	6.71	29514104
2195	Phosphorylation	RTERTEISKTRGGET EEEEEEEEECCCCCE	23.03	29514104
2234	Phosphorylation	LGRERLGSFGSITRQ HCCCCCCCCCCCCCC	30.90	27087446
2237	Phosphorylation	ERLGSFGSITRQQEG CCCCCCCCCCCCCCC	20.83	26824392
2239	Phosphorylation	LGSFGSITRQQEGEA CCCCCCCCCCCCCCC	24.91	27742792
2247	Phosphorylation	RQQEGEASSQDMTAQ CCCCCCCCCCCCEEE	24.99	26160508
2248	Phosphorylation	QQEGEASSQDMTAQV CCCCCCCCCCCEEEE	36.93	23649490
2257	Phosphorylation	DMTAQVTSPSGKTEA CCEEEEECCCCCCEE	20.43	28542873
2273	Phosphorylation	EIVEGEDSAYSVRFV EEECCCCCCEEEEEE	25.46	27742792
2275	Phosphorylation	VEGEDSAYSVRFVPQ ECCCCCCEEEEEECC	16.20	21149613
2276	Phosphorylation	EGEDSAYSVRFVPQE CCCCCCEEEEEECCC	13.41	21149613
2292	Ubiquitination	GPHTVTVKYRGQHVP CCCEEEEEECCEECC	21.62	-
2301	Phosphorylation	RGQHVPGSPFQFTVG CCEECCCCCCEEEEE	19.23	26824392
2396	Phosphorylation	NDEHIPDSPFVVPVA CCCCCCCCCEEEEEE	18.19	26824392
2413	Phosphorylation	SDDARRLTVTSLQET CHHHHHEEEEEHHHH	21.67	22210690
2415	Phosphorylation	DARRLTVTSLQETGL HHHHEEEEEHHHHCC	20.63	22210690
2416	Phosphorylation	ARRLTVTSLQETGLK HHHEEEEEHHHHCCC	24.58	22210690
2420	Phosphorylation	TVTSLQETGLKVNQP EEEEHHHHCCCCCCC	34.55	21454597
2447	Phosphorylation	VIDARVHTPSGAVEE EEEEEEECCCCCCEE	19.12	26824392
2449	Phosphorylation	DARVHTPSGAVEECY EEEEECCCCCCEEEE	40.31	27742792
2456	Phosphorylation	SGAVEECYVSELDSD CCCCEEEEEEECCCC	15.41	27742792
2458	Phosphorylation	AVEECYVSELDSDKH CCEEEEEEECCCCCC	13.13	27742792
2462	Phosphorylation	CYVSELDSDKHTIRF EEEEECCCCCCEEEE	62.27	27742792
2466	Phosphorylation	ELDSDKHTIRFIPHE ECCCCCCEEEEEECC	21.42	27742792
2491	Phosphorylation	NGAHIPGSPFKIRVG CCEECCCCCEEEEEC	23.08	26824392
2587	Phosphorylation	GPQHIVGSPFKAKVT CCCCEECCCCCCEEC	19.10	-
2594	Phosphorylation	SPFKAKVTGPRLSGG CCCCCEECCCCCCCC	40.54	23984901
2599	Phosphorylation	KVTGPRLSGGHSLHE EECCCCCCCCCCCCC	43.97	21659605
2603	Phosphorylation	PRLSGGHSLHETSTV CCCCCCCCCCCCCEE	34.39	26824392
2607	Phosphorylation	GGHSLHETSTVLVET CCCCCCCCCEEEEEE	20.96	23984901
2608	Phosphorylation	GHSLHETSTVLVETV CCCCCCCCEEEEEEE	17.34	23984901
2609	Phosphorylation	HSLHETSTVLVETVT CCCCCCCEEEEEEEC	25.86	23984901
2614	Phosphorylation	TSTVLVETVTKSSSS CCEEEEEEECCCCCC	26.46	25777480
2618	Phosphorylation	LVETVTKSSSSRGAS EEEEECCCCCCCCCC	26.53	25338131
2620	Phosphorylation	ETVTKSSSSRGASYS EEECCCCCCCCCCCC	31.01	25338131
2621	Phosphorylation	TVTKSSSSRGASYSS EECCCCCCCCCCCCC	36.36	25338131
2625	Phosphorylation	SSSSRGASYSSIPKF CCCCCCCCCCCCCCC	28.50	26824392
2626	Phosphorylation	SSSRGASYSSIPKFS CCCCCCCCCCCCCCC	13.10	22499769
2627	Phosphorylation	SSRGASYSSIPKFSS CCCCCCCCCCCCCCC	21.21	22499769
2628	Phosphorylation	SRGASYSSIPKFSSD CCCCCCCCCCCCCCC	34.38	22499769
2633	Phosphorylation	YSSIPKFSSDASKVV CCCCCCCCCCCHHEE	33.17	23737553
2634	Phosphorylation	SSIPKFSSDASKVVT CCCCCCCCCCHHEEE	40.09	27742792
2637	Phosphorylation	PKFSSDASKVVTRGP CCCCCCCHHEEECCC	30.85	27742792
2656	Phosphorylation	AFVGQKNSFTVDCSK HHCCCCCEEEEECHH	29.36	23375375
2678	Phosphorylation	VGVHGPKTPCEEVYV EEECCCCCCCEEEEE	35.98	23375375
2684	Phosphorylation	KTPCEEVYVKHMGNR CCCCEEEEEEECCCE	13.68	22499769
2686	Acetylation	PCEEVYVKHMGNRVY CCEEEEEEECCCEEE	15.36	22826441
2693	Phosphorylation	KHMGNRVYNVTYTVK EECCCEEEEEEEEEE	10.73	28576409
2696	Phosphorylation	GNRVYNVTYTVKEKG CCEEEEEEEEEEECC	15.16	28576409
2697	Phosphorylation	NRVYNVTYTVKEKGD CEEEEEEEEEEECCC	12.78	28576409
2698	Phosphorylation	RVYNVTYTVKEKGDY EEEEEEEEEEECCCE	18.75	28576409
2700	Acetylation	YNVTYTVKEKGDYIL EEEEEEEEECCCEEE	46.00	23236377
2715	Phosphorylation	IVKWGDESVPGSPFK EEEECCCCCCCCCCE	38.05	29514104
2719	Phosphorylation	GDESVPGSPFKVNVP CCCCCCCCCCEECCC	22.54	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2625	S	Phosphorylation	Kinase	PKACA	P05132	PSP
2625	S	Phosphorylation	Kinase	PKCA	P17252	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Klhl31	Q8BWA5	PMID:28872460

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLNC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLNC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FLNC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2234, AND MASSSPECTROMETRY.
PubMed: 19131326