K22E_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K22E_MOUSE
• UniProt AC: Q3TTY5
• Protein Name: Keratin, type II cytoskeletal 2 epidermal
• Gene Name: Krt2 {ECO:0000312|EMBL:AAI20486.1}
• Organism: Mus musculus (Mouse).
• Sequence Length: 707
• Protein Description: Probably contributes to terminal cornification (By similarity). Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin. [PubMed: 26603179]
• Protein Sequence: MSCQISCRSRRGGGGGGGGGFRGFSSGSAVVSGGSRRSNTSFSCISRHGGGRGGSGGGGFGSQSLVGLGGYKSISSSVAGNSGGYGGSSFGGSSGFGGGRGFGGGQGFGGSGGFGGGSGFGGGQGFGGGSRFGGGSGFGGGGFGGGSFGGGRFGGGPGGFGGPGGFPGGGIHEVSVNQSLLQPLDVKVDPEIQNVKSQEREQIKTLNNKFASFIDKVRFLEQQNQVLRTKWELLQQLDVGSRTTNLDPIFQAYIGMLKKQVDRLSAERTSQESELNNMQDLVEDFKKKYEDEINKRTSAENDFVTIKKDVDSCYMDKTELQARLDILAQEVNFLRTLYDAELSQLQQDVTDTNVILSMDNNRNLDLDSIIAEVQNQYEMIAHKSKAESEELYHSKYEELQVTAVKHGDSLKEIKMEISELNRTIQRLQGEISHVKKQCKGVQDSIADAEQRGEHAIKDARGKLTDLEEALQQCREDLARLLRDYQELMNTKLSLDVEIATYRKLLEGEECRMSGDFSDNVSVSITSSTISSSVASKTGFGSGGQSSGGRGSYGGRGGGGGGGSTYGSGGRSSGSRGSGSGSGGGGYSSGGGSRGGSGGGYGSGGGSRGGSGGGYGSGGGSGSGGGYSSGGGSRGGSGGGGVSSGGGSRGGSSSGGGSRGGSSSGGGGYSSGGGSRGGSSSGGAGSSSEKGGSGSGEGCGSGVTFSFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSCQISCRSRRGG --CCCEEEECCCCCC	4.24	19367708
22	Asymmetric dimethylarginine	GGGGGGFRGFSSGSA CCCCCCCCCCCCCCE	48.82	-
22	Methylation	GGGGGGFRGFSSGSA CCCCCCCCCCCCCCE	48.82	24129315
25	Phosphorylation	GGGFRGFSSGSAVVS CCCCCCCCCCCEEEE	36.29	26643407
26	Phosphorylation	GGFRGFSSGSAVVSG CCCCCCCCCCEEEEC	34.21	26643407
28	Phosphorylation	FRGFSSGSAVVSGGS CCCCCCCCEEEECCC	21.60	26643407
32	Phosphorylation	SSGSAVVSGGSRRSN CCCCEEEECCCCCCC	30.73	26643407
35	Phosphorylation	SAVVSGGSRRSNTSF CEEEECCCCCCCCCE	28.22	26643407
38	Phosphorylation	VSGGSRRSNTSFSCI EECCCCCCCCCEEEE	43.26	22817900
40	Phosphorylation	GGSRRSNTSFSCISR CCCCCCCCCEEEEEE	32.18	22817900
41	Phosphorylation	GSRRSNTSFSCISRH CCCCCCCCEEEEEEC	21.29	22817900
43	Phosphorylation	RRSNTSFSCISRHGG CCCCCCEEEEEECCC	15.42	22817900
46	Phosphorylation	NTSFSCISRHGGGRG CCCEEEEEECCCCCC	23.66	22817900
52	Methylation	ISRHGGGRGGSGGGG EEECCCCCCCCCCCC	49.96	24129315
55	Phosphorylation	HGGGRGGSGGGGFGS CCCCCCCCCCCCCCC	36.77	22817900
62	Phosphorylation	SGGGGFGSQSLVGLG CCCCCCCCCCCEECC	17.84	22817900
64	Phosphorylation	GGGFGSQSLVGLGGY CCCCCCCCCEECCCC	27.07	22817900
88	Phosphorylation	NSGGYGGSSFGGSSG CCCCCCCCCCCCCCC	20.38	22817900
89	Phosphorylation	SGGYGGSSFGGSSGF CCCCCCCCCCCCCCC	31.05	19367708
93	Phosphorylation	GGSSFGGSSGFGGGR CCCCCCCCCCCCCCC	27.89	22817900
94	Phosphorylation	GSSFGGSSGFGGGRG CCCCCCCCCCCCCCC	41.22	22817900
111	Phosphorylation	GGQGFGGSGGFGGGS CCCCCCCCCCCCCCC	35.80	22817900
118	Phosphorylation	SGGFGGGSGFGGGQG CCCCCCCCCCCCCCC	33.93	19367708
118	O-linked_Glycosylation	SGGFGGGSGFGGGQG CCCCCCCCCCCCCCC	33.93	14203875
130	Phosphorylation	GQGFGGGSRFGGGSG CCCCCCCCCCCCCCC	27.93	-
130	O-linked_Glycosylation	GQGFGGGSRFGGGSG CCCCCCCCCCCCCCC	27.93	55412377
136	Phosphorylation	GSRFGGGSGFGGGGF CCCCCCCCCCCCCCC	33.93	22817900
147	Phosphorylation	GGGFGGGSFGGGRFG CCCCCCCCCCCCCCC	24.80	22817900
193	Ubiquitination	VKVDPEIQNVKSQER CCCCHHHHCCHHHHH	47.18	27667366
197	Phosphorylation	PEIQNVKSQEREQIK HHHHCCHHHHHHHHH	32.75	19367708
205	Phosphorylation	QEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	29899451
209	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
212	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22817900
216	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	27667366
265	Phosphorylation	KKQVDRLSAERTSQE HHHHHHHHHHHCHHH	29.04	24719451
269	Phosphorylation	DRLSAERTSQESELN HHHHHHHCHHHHHHH	26.68	22817900
270	Phosphorylation	RLSAERTSQESELNN HHHHHHCHHHHHHHH	37.87	19367708
312	Phosphorylation	TIKKDVDSCYMDKTE EEECCCCCCCCCHHH	13.65	19367708
368	Phosphorylation	NRNLDLDSIIAEVQN CCCCCHHHHHHHHHH	24.16	19367708
388	Phosphorylation	AHKSKAESEELYHSK HHHHHHHHHHHHHHC	41.03	22817900
402	Phosphorylation	KYEELQVTAVKHGDS CCCCCEEEEEECCCC	16.87	21454597
480	Ubiquitination	CREDLARLLRDYQEL HHHHHHHHHHHHHHH	3.70	27667366
503	Ubiquitination	VEIATYRKLLEGEEC HHHHHHHHHHCCCCC	47.19	27667366
541	Phosphorylation	ASKTGFGSGGQSSGG HHCCCCCCCCCCCCC	37.17	22817900
546	Phosphorylation	FGSGGQSSGGRGSYG CCCCCCCCCCCCCCC	37.06	22817900
551	Phosphorylation	QSSGGRGSYGGRGGG CCCCCCCCCCCCCCC	21.17	22817900
555	Methylation	GRGSYGGRGGGGGGG CCCCCCCCCCCCCCC	35.90	24129315
563	Phosphorylation	GGGGGGGSTYGSGGR CCCCCCCCCCCCCCC	23.02	22817900
564	Phosphorylation	GGGGGGSTYGSGGRS CCCCCCCCCCCCCCC	34.87	22817900
567	Phosphorylation	GGGSTYGSGGRSSGS CCCCCCCCCCCCCCC	27.88	19367708
571	Phosphorylation	TYGSGGRSSGSRGSG CCCCCCCCCCCCCCC	42.18	22817900
572	Phosphorylation	YGSGGRSSGSRGSGS CCCCCCCCCCCCCCC	39.15	22817900
574	Phosphorylation	SGGRSSGSRGSGSGS CCCCCCCCCCCCCCC	35.10	22817900
577	Phosphorylation	RSSGSRGSGSGSGGG CCCCCCCCCCCCCCC	28.77	25890499
579	Phosphorylation	SGSRGSGSGSGGGGY CCCCCCCCCCCCCCC	31.33	22817900
581	Phosphorylation	SRGSGSGSGGGGYSS CCCCCCCCCCCCCCC	35.64	22817900
587	Phosphorylation	GSGGGGYSSGGGSRG CCCCCCCCCCCCCCC	26.28	22817900
588	Phosphorylation	SGGGGYSSGGGSRGG CCCCCCCCCCCCCCC	32.73	22817900
592	Phosphorylation	GYSSGGGSRGGSGGG CCCCCCCCCCCCCCC	30.90	22817900
592	O-linked_Glycosylation	GYSSGGGSRGGSGGG CCCCCCCCCCCCCCC	30.90	14203815
593	Methylation	YSSGGGSRGGSGGGY CCCCCCCCCCCCCCC	57.68	24129315
596	Phosphorylation	GGGSRGGSGGGYGSG CCCCCCCCCCCCCCC	36.77	26239621
596	O-linked_Glycosylation	GGGSRGGSGGGYGSG CCCCCCCCCCCCCCC	36.77	14203883
600	Phosphorylation	RGGSGGGYGSGGGSR CCCCCCCCCCCCCCC	16.05	26239621
602	Phosphorylation	GSGGGYGSGGGSRGG CCCCCCCCCCCCCCC	26.27	26239621
606	Phosphorylation	GYGSGGGSRGGSGGG CCCCCCCCCCCCCCC	30.90	22817900
607	Methylation	YGSGGGSRGGSGGGY CCCCCCCCCCCCCCC	57.68	-
610	Phosphorylation	GGGSRGGSGGGYGSG CCCCCCCCCCCCCCC	36.77	19367708
616	Phosphorylation	GSGGGYGSGGGSGSG CCCCCCCCCCCCCCC	26.27	19367708
620	Phosphorylation	GYGSGGGSGSGGGYS CCCCCCCCCCCCCCC	32.82	19367708
622	Phosphorylation	GSGGGSGSGGGYSSG CCCCCCCCCCCCCCC	35.64	19367708
628	Phosphorylation	GSGGGYSSGGGSRGG CCCCCCCCCCCCCCC	32.73	19367708
632	Phosphorylation	GYSSGGGSRGGSGGG CCCCCCCCCCCCCCC	30.90	-
636	Phosphorylation	GGGSRGGSGGGGVSS CCCCCCCCCCCCCCC	36.77	22817900
642	Phosphorylation	GSGGGGVSSGGGSRG CCCCCCCCCCCCCCC	26.92	22817900
643	Phosphorylation	SGGGGVSSGGGSRGG CCCCCCCCCCCCCCC	38.77	19367708
647	O-linked_Glycosylation	GVSSGGGSRGGSSSG CCCCCCCCCCCCCCC	30.90	14203743
647	Phosphorylation	GVSSGGGSRGGSSSG CCCCCCCCCCCCCCC	30.90	22817900
651	Phosphorylation	GGGSRGGSSSGGGSR CCCCCCCCCCCCCCC	24.93	26239621
652	Phosphorylation	GGSRGGSSSGGGSRG CCCCCCCCCCCCCCC	35.96	26239621
653	Phosphorylation	GSRGGSSSGGGSRGG CCCCCCCCCCCCCCC	43.06	26239621
657	Phosphorylation	GSSSGGGSRGGSSSG CCCCCCCCCCCCCCC	30.90	26239621
661	Phosphorylation	GGGSRGGSSSGGGGY CCCCCCCCCCCCCCC	24.93	19367708
662	Phosphorylation	GGSRGGSSSGGGGYS CCCCCCCCCCCCCCC	35.96	25890499
663	Phosphorylation	GSRGGSSSGGGGYSS CCCCCCCCCCCCCCC	43.06	22817900
670	Phosphorylation	SGGGGYSSGGGSRGG CCCCCCCCCCCCCCC	32.73	19367708
674	Phosphorylation	GYSSGGGSRGGSSSG CCCCCCCCCCCCCCC	30.90	19367708
675	Methylation	YSSGGGSRGGSSSGG CCCCCCCCCCCCCCC	57.68	-
678	Phosphorylation	GGGSRGGSSSGGAGS CCCCCCCCCCCCCCC	24.93	19367708
680	Phosphorylation	GSRGGSSSGGAGSSS CCCCCCCCCCCCCCC	42.83	19367708
685	Phosphorylation	SSSGGAGSSSEKGGS CCCCCCCCCCCCCCC	30.11	22817900
686	Phosphorylation	SSGGAGSSSEKGGSG CCCCCCCCCCCCCCC	41.41	25890499
687	Phosphorylation	SGGAGSSSEKGGSGS CCCCCCCCCCCCCCC	45.05	25890499
692	Phosphorylation	SSSEKGGSGSGEGCG CCCCCCCCCCCCCCC	38.15	22817900
694	Phosphorylation	SEKGGSGSGEGCGSG CCCCCCCCCCCCCCC	35.05	22817900
700	Phosphorylation	GSGEGCGSGVTFSFR CCCCCCCCCCEEEEC	33.88	19367708

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K22E_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K22E_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K22E_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K22E_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388 AND SER-606, ANDMASS SPECTROMETRY.
PubMed: 19367708