ANXA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA2_MOUSE
• UniProt AC: P07356
• Protein Name: Annexin A2
• Gene Name: Anxa2
• Organism: Mus musculus (Mouse).
• Sequence Length: 339
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. In the lamina beneath the plasma membrane.
• Protein Description: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. [PubMed: 22848640]
• Protein Sequence: MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTVHEILC ------CCCHHHHHH	38.85	-
2	Phosphorylation	------MSTVHEILC ------CCCHHHHHH	38.85	26824392
3	Phosphorylation	-----MSTVHEILCK -----CCCHHHHHHH	25.28	26824392
10	Sumoylation	TVHEILCKLSLEGDH CHHHHHHHHHCCCCC	37.35	-
12	Phosphorylation	HEILCKLSLEGDHST HHHHHHHHCCCCCCC	15.18	26824392
18	Phosphorylation	LSLEGDHSTPPSAYG HHCCCCCCCCCHHCC	47.55	21082442
19	Phosphorylation	SLEGDHSTPPSAYGS HCCCCCCCCCHHCCC	35.48	25619855
22	Phosphorylation	GDHSTPPSAYGSVKP CCCCCCCHHCCCCCC	35.01	9403731
24	Phosphorylation	HSTPPSAYGSVKPYT CCCCCHHCCCCCCCC	17.80	26824392
26	Phosphorylation	TPPSAYGSVKPYTNF CCCHHCCCCCCCCCC	17.81	25619855
28	Acetylation	PSAYGSVKPYTNFDA CHHCCCCCCCCCCCH	33.72	23806337
30	Phosphorylation	AYGSVKPYTNFDAER HCCCCCCCCCCCHHH	14.48	25619855
31	Phosphorylation	YGSVKPYTNFDAERD CCCCCCCCCCCHHHH	37.63	25619855
44	Phosphorylation	RDALNIETAVKTKGV HHCCCHHHHHHCCCC	32.71	22499769
49	Ubiquitination	IETAVKTKGVDEVTI HHHHHHCCCCCEEEE	51.74	22790023
49	Acetylation	IETAVKTKGVDEVTI HHHHHHCCCCCEEEE	51.74	23806337
75	Phosphorylation	RQDIAFAYQRRTKKE HHHHHHHHHHCCHHH	8.97	29514104
81	Acetylation	AYQRRTKKELPSALK HHHHCCHHHHCHHHH	64.96	22826441
89	Phosphorylation	ELPSALKSALSGHLE HHCHHHHHHHHCCHH	34.98	23984901
92	Phosphorylation	SALKSALSGHLETVI HHHHHHHHCCHHHHH	24.71	27180971
97	Phosphorylation	ALSGHLETVILGLLK HHHCCHHHHHHHHHC	21.14	23984901
112	Phosphorylation	TPAQYDASELKASMK CHHHCCHHHHHHHHC	40.33	25338131
115	Ubiquitination	QYDASELKASMKGLG HCCHHHHHHHHCCCC	34.07	22790023
115	Acetylation	QYDASELKASMKGLG HCCHHHHHHHHCCCC	34.07	22733758
123	Phosphorylation	ASMKGLGTDEDSLIE HHHCCCCCCHHHHHH	41.06	23984901
127	Phosphorylation	GLGTDEDSLIEIICS CCCCCHHHHHHHHHH	29.24	26824392
133	S-nitrosocysteine	DSLIEIICSRTNQEL HHHHHHHHHCCHHHH	2.50	-
133	Glutathionylation	DSLIEIICSRTNQEL HHHHHHHHHCCHHHH	2.50	24333276
133	S-nitrosylation	DSLIEIICSRTNQEL HHHHHHHHHCCHHHH	2.50	22588120
136	Phosphorylation	IEIICSRTNQELQEI HHHHHHCCHHHHHHH	25.59	26239621
148	Ubiquitination	QEINRVYKEMYKTDL HHHHHHHHHHHCCHH	32.90	22790023
148	Acetylation	QEINRVYKEMYKTDL HHHHHHHHHHHCCHH	32.90	22826441
152	Acetylation	RVYKEMYKTDLEKDI HHHHHHHCCHHHHHH	33.96	23806337
157	Acetylation	MYKTDLEKDIISDTS HHCCHHHHHHHCCCC	62.62	22826441
161	Phosphorylation	DLEKDIISDTSGDFR HHHHHHHCCCCHHHH	34.86	26060331
163	Phosphorylation	EKDIISDTSGDFRKL HHHHHCCCCHHHHHH	28.02	26824392
164	Phosphorylation	KDIISDTSGDFRKLM HHHHCCCCHHHHHHH	41.16	27180971
169	Acetylation	DTSGDFRKLMVALAK CCCHHHHHHHHHHHC	40.71	22733758
176	Acetylation	KLMVALAKGRRAEDG HHHHHHHCCCCCCCC	54.52	23236377
184	Phosphorylation	GRRAEDGSVIDYELI CCCCCCCCCCCCEEC	28.37	25619855
188	Phosphorylation	EDGSVIDYELIDQDA CCCCCCCCEECCHHH	11.08	25619855
199	Phosphorylation	DQDARELYDAGVKRK CHHHHHHHHHCCCCC	10.05	22499769
204	Acetylation	ELYDAGVKRKGTDVP HHHHHCCCCCCCCCC	47.69	7612875
212	Acetylation	RKGTDVPKWISIMTE CCCCCCCHHHHHHHH	57.94	22826441
215	Phosphorylation	TDVPKWISIMTERSV CCCCHHHHHHHHHHH	12.75	27180971
223	Glutathionylation	IMTERSVCHLQKVFE HHHHHHHHHHHHHHH	2.53	24333276
227	Acetylation	RSVCHLQKVFERYKS HHHHHHHHHHHHHHC	56.08	23806337
227	Malonylation	RSVCHLQKVFERYKS HHHHHHHHHHHHHHC	56.08	26320211
233	Acetylation	QKVFERYKSYSPYDM HHHHHHHHCCCHHHH	49.49	23806337
233	Succinylation	QKVFERYKSYSPYDM HHHHHHHHCCCHHHH	49.49	23806337
234	Phosphorylation	KVFERYKSYSPYDML HHHHHHHCCCHHHHH	23.16	29514104
235	Phosphorylation	VFERYKSYSPYDMLE HHHHHHCCCHHHHHH	14.98	29514104
236	Phosphorylation	FERYKSYSPYDMLES HHHHHCCCHHHHHHH	24.87	30460009
238	Phosphorylation	RYKSYSPYDMLESIK HHHCCCHHHHHHHHH	14.19	16873679
245	Acetylation	YDMLESIKKEVKGDL HHHHHHHHHHHCCHH	52.76	23236377
262	S-nitrosylation	AFLNLVQCIQNKPLY HHHHHHHHHHCCCCH	2.42	20925432
262	S-nitrosocysteine	AFLNLVQCIQNKPLY HHHHHHHHHHCCCCH	2.42	-
262	Glutathionylation	AFLNLVQCIQNKPLY HHHHHHHHHHCCCCH	2.42	24333276
275	Phosphorylation	LYFADRLYDSMKGKG CHHHHHHHHHHCCCC	13.58	22499769
277	Phosphorylation	FADRLYDSMKGKGTR HHHHHHHHHCCCCCC	14.61	22499769
279	Acetylation	DRLYDSMKGKGTRDK HHHHHHHCCCCCCCH	62.51	23236377
279	Malonylation	DRLYDSMKGKGTRDK HHHHHHHCCCCCCCH	62.51	26320211
302	Ubiquitination	RSEVDMLKIRSEFKR HHHHHHHHHHHHHHH	29.45	22790023
302	Acetylation	RSEVDMLKIRSEFKR HHHHHHHHHHHHHHH	29.45	23236377
310	Acetylation	IRSEFKRKYGKSLYY HHHHHHHHHCCCCEE	59.97	22826441
311	Phosphorylation	RSEFKRKYGKSLYYY HHHHHHHHCCCCEEE	33.54	22817900
313	Malonylation	EFKRKYGKSLYYYIQ HHHHHHCCCCEEEEE	33.91	26320211
313	Acetylation	EFKRKYGKSLYYYIQ HHHHHHCCCCEEEEE	33.91	23806337
314	Phosphorylation	FKRKYGKSLYYYIQQ HHHHHCCCCEEEEEC	19.76	22499769
316	Phosphorylation	RKYGKSLYYYIQQDT HHHCCCCEEEEECCC	11.00	20116462
317	Phosphorylation	KYGKSLYYYIQQDTK HHCCCCEEEEECCCC	10.21	22499769
318	Phosphorylation	YGKSLYYYIQQDTKG HCCCCEEEEECCCCC	4.43	22499769
324	Acetylation	YYIQQDTKGDYQKAL EEEECCCCCCHHHHH	59.06	22826441
324	Ubiquitination	YYIQQDTKGDYQKAL EEEECCCCCCHHHHH	59.06	22790023
329	Acetylation	DTKGDYQKALLYLCG CCCCCHHHHHHHHCC	34.47	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
24	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot
26	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYSF_MOUSE	Dysf	physical	14506282
PLOD1_HUMAN	PLOD1	physical	26496610
PLOD2_HUMAN	PLOD2	physical	26496610
PEPL_HUMAN	PPL	physical	26496610
S10AA_HUMAN	S100A10	physical	26496610
PLOD3_HUMAN	PLOD3	physical	26496610
AHNK_HUMAN	AHNAK	physical	26496610
GT251_HUMAN	COLGALT1	physical	26496610
AHNK2_HUMAN	AHNAK2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.