DYSF_MOUSE - dbPTM
DYSF_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DYSF_MOUSE
UniProt AC Q9ESD7
Protein Name Dysferlin
Gene Name Dysf
Organism Mus musculus (Mouse).
Sequence Length 2090
Subcellular Localization Cell membrane, sarcolemma
Single-pass type II membrane protein. Cytoplasmic vesicle membrane
Single-pass type II membrane protein. Cell membrane. Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the
Protein Description Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress..
Protein Sequence MLRVFILFAENVHTPDSDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQSSELLVVVKDHETMGRNRFLGEAKIPLQEVLATPSLSASFNAPLLDAKQQPTGASLVLQVSYTPPPGAVPLFPPPASLAPSPTLPDMDLVPDTGGEEDTEDQGLTGDEAEPFLDQSAAVGPGGPTTPRKPPSHPPPHYPGAKRKRSSAPPRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIQKGNSPLFNETLFFNVFDSPLELFDEPIFITVVDSRSLRTDALLGEFRMDVGTVYREPRHAYLRKWLLLSDPDDFSAGARGYLKASLCVLGPGDEAPLDKKDPSEDKEDIEGNLLRPTGVALRGAHFCLKLFRAEDLPQMDDAVMDNVKQIFGFDSNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRVMDWDRLTHNDTVATTYLGMSKISATGGEIEEEPAGVLKSPQATDLDDNLGFLPTFGPCYVNLYGSPREFTGFPDPYAELNTGKGEGVAYRGRVLLSLETKLVEHSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDTTCLPLASTTQYSRAVFDGGSLPLPVGCHYYYLPWGNVKPVVVLSSYWEDISHRIEIQNQLLRVADRLEANLEQVHLALKAQCSSEDVDALVAQLTDELLADCSQPLCDIHEIPSATHLDQYLLRLRTRHLSQIKEAALALKLGHSELSTALEQAEDWLLHLRALAEEPQNSLPDIIIWMLQGDKRVAYQRVPAHEVLFSRRGPSYCGRNCGKLQTIFLKYPMEGMPGARMPVQIRIKLWFGLSVDEKEFNQFAEGKLSVFAETYENQTKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWAWAGDWFVCPEKTLLHDADAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPDRKPKHWVPVEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGMVDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYLYQARDLPAMDKDSFSDPYAIVSFLHQSQKTVVEKNTLNPTWDQTLIFYEIEIFGEPASIAEHPPCIVVELYDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPAGELLAAFELIQREKPAIHHIPGFEMHETSRILDETEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQMASISSPSLVVECGGQTVQSCVIRNLRKNPNFDVCTLFMEVMLPREDLYCPPIVVKVIDNRQFGRRPVVGQCTIRSLENFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPVQEEEFIDWWSKFFASVGEREKCGSYLEKDFDTLKVYDTQLENVEAFGGLSDFCNTFKLYRGRTQEETDDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVIDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRIKAPVYRTDRVTFQDKDYTIEEIEAGRLPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWIDIFPKVLGRPGPPFNITPRKARRFFLRCIIWNTKDVILDDLSLTGEKMSDIYVKGWMVGFEEHKQKTDVHYRSLGGEGNFNWRFVFPFDYLPAEQVCAVAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAEKCSLDQLDDTFHPEWFVSLFEQKTVKGWWPCVTEEGEKKMLAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRCAIILFIILFILLLFLGVFVYAFPNYAAMKLVKPFR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
160PhosphorylationDTGGEEDTEDQGLTG
CCCCCCCCCCCCCCC		44.7521183079
162 (in isoform 2)Phosphorylation-50.3623737553
164 (in isoform 2)Phosphorylation-37.2127180971
166PhosphorylationDTEDQGLTGDEAEPF
CCCCCCCCCCCCCCC		49.7821183079
167 (in isoform 2)Phosphorylation-35.4927180971
169 (in isoform 2)Phosphorylation-57.1723737553
170 (in isoform 2)Phosphorylation-34.2123737553
173 (in isoform 2)Phosphorylation-9.8823737553
176 (in isoform 2)Phosphorylation-36.8025338131
177PhosphorylationAEPFLDQSAAVGPGG
CCCCCCCCCCCCCCC		20.1921183079
184 (in isoform 2)Phosphorylation-21.3723737553
186 (in isoform 2)Phosphorylation-53.3523737553
187PhosphorylationVGPGGPTTPRKPPSH
CCCCCCCCCCCCCCC		24.9921183079
192 (in isoform 2)Phosphorylation-48.5923737553
193PhosphorylationTTPRKPPSHPPPHYP
CCCCCCCCCCCCCCC		58.0926824392
198 (in isoform 2)Phosphorylation-47.3929514104
199PhosphorylationPSHPPPHYPGAKRKR
CCCCCCCCCCCCCCC		14.7720469934
207PhosphorylationPGAKRKRSSAPPRKL
CCCCCCCCCCCCCHH		33.6123684622
209 (in isoform 2)Phosphorylation-21.2523984901
213 (in isoform 2)Ubiquitination-60.6022790023
213UbiquitinationRSSAPPRKLLSDKPQ
CCCCCCCHHCCCCCC		60.6022790023
218 (in isoform 2)Phosphorylation-41.0025338131
218 (in isoform 2)Ubiquitination-41.0022790023
218UbiquitinationPRKLLSDKPQDFQIR
CCHHCCCCCCCEEEE		41.0022790023
219 (in isoform 2)Phosphorylation-43.9223984901
245 (in isoform 2)Ubiquitination-2.73-
250 (in isoform 2)Ubiquitination-38.84-
251PhosphorylationKVTAAGQTKRTRIQK
EEEECCCCCCCCCCC		22.9021183079
344S-nitrosocysteineGYLKASLCVLGPGDE
HHCEEEEEEECCCCC		1.89-
344S-nitrosylationGYLKASLCVLGPGDE
HHCEEEEEEECCCCC		1.8920925432
449PhosphorylationPQWNQNITLPAMFPS
CCCCCCCCCCHHCHH		33.9527566939
535PhosphorylationYGSPREFTGFPDPYA
CCCCCCCCCCCCCCC		32.9125168779
541PhosphorylationFTGFPDPYAELNTGK
CCCCCCCCCCCCCCC		21.7925168779
546PhosphorylationDPYAELNTGKGEGVA
CCCCCCCCCCCCCCC		53.5525168779
548UbiquitinationYAELNTGKGEGVAYR
CCCCCCCCCCCCCHH		52.3122790023
548 (in isoform 2)Ubiquitination-52.3122790023
566 (in isoform 2)Ubiquitination-7.74-
594PhosphorylationKYLRRRKYSLFAAFY
HHHHHHCHHHHHHHH		14.5925293948
595PhosphorylationYLRRRKYSLFAAFYS
HHHHHCHHHHHHHHH		21.7525293948
601PhosphorylationYSLFAAFYSATMLQD
HHHHHHHHHHHHCCC		7.8325293948
602PhosphorylationSLFAAFYSATMLQDV
HHHHHHHHHHHCCCC		15.7125293948
604PhosphorylationFAAFYSATMLQDVDD
HHHHHHHHHCCCCCH		16.6925293948
618PhosphorylationDAIQFEVSIGNYGNK
HHHEEEEECCCCCCC		19.9925293948
622PhosphorylationFEVSIGNYGNKFDTT
EEEECCCCCCCCCCC		19.5025293948
834S-nitrosocysteineSRRGPSYCGRNCGKL
CCCCCCCCCCCCCCC		4.91-
834S-nitrosylationSRRGPSYCGRNCGKL
CCCCCCCCCCCCCCC		4.9121278135
871PhosphorylationIKLWFGLSVDEKEFN
EEEEECCCCCHHHHH		28.0925338131
1067UbiquitinationLSQMEALKRHRQAEA
HHHHHHHHHHHHHHH		53.8822790023
1067 (in isoform 2)Ubiquitination-53.8822790023
1077 (in isoform 2)Ubiquitination-53.27-
1532GlutathionylationFGGLSDFCNTFKLYR
CCCHHHHHHHHHHHC		5.8724333276
1542PhosphorylationFKLYRGRTQEETDDP
HHHHCCCCCCCCCCC		43.0627742792
1550PhosphorylationQEETDDPSVIGEFKG
CCCCCCCHHHHEECC		33.1028464351
1556UbiquitinationPSVIGEFKGLFKIYP
CHHHHEECCCEEEEE		50.8622790023
1556 (in isoform 2)Ubiquitination-50.8622790023
1566 (in isoform 2)Ubiquitination-81.79-
1619UbiquitinationYIKISIGKKSVSDQD
CEEEEECCCCCCCCC		39.96-
1668AcetylationDLLSKDEKIGETVID
CCCCCCCCCCCHHHH		67.1723236377
1683UbiquitinationLENRLLSKFGARCGL
HHHHHHHHHCCCCCC		48.0322790023
1683 (in isoform 2)Ubiquitination-48.0322790023
1693 (in isoform 2)Ubiquitination-19.56-
1736UbiquitinationDRVTFQDKDYTIEEI
CCEEECCCCCEEEEH		41.6822790023
1736 (in isoform 2)Ubiquitination-41.6822790023
1746 (in isoform 2)Ubiquitination-20.90-
1781PhosphorylationHVESRPLYSPLQPDI
CCCCCCCCCCCCCCH		15.7829233185
1782PhosphorylationVESRPLYSPLQPDIE
CCCCCCCCCCCCCHH		27.1529233185
1839PhosphorylationDVILDDLSLTGEKMS
CEEEHHCCCCCCCHH		30.7725338131
1841PhosphorylationILDDLSLTGEKMSDI
EEHHCCCCCCCHHHE		39.6625338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DYSF_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DYSF_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DYSF_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANXA1_MOUSEAnxa1physical
14506282
ANXA2_MOUSEAnxa2physical
14506282
RIPR2_MOUSEFam65bphysical
24687993
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DYSF_MOUSE

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Related Literatures of Post-Translational Modification

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