RIPR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIPR2_MOUSE
• UniProt AC: Q80U16
• Protein Name: Rho family-interacting cell polarization regulator 2 {ECO:0000250|UniProtKB:Q9Y4F9}
• Gene Name: Ripor2 {ECO:0000250|UniProtKB:Q9Y4F9}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1078
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, filopodium . Cell projection, stereocilium . Cell projection, stereocilium membrane . Apical cell membrane . Localized in the cytoplasm in cells undergoing mitosis (By similarity). Colocalized wi
• Protein Description: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. [PubMed: 25588844]
• Protein Sequence: MPPGTKRLRALGAFSAGLPTRLPEIMLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENASALKKPQAKLKKMHNLGHKNNNTPKEPQPKRVEEVYRALKNGLDEYLEFHQTELDKLTAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLSEINRSYKEYTENMCAIEAELESLLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGKIEVNGKQSWDGAETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMSMYSQGTPETPTFKDQSFFRWLRLSVLSALRDTFFATLHHNHSVGDLPSLSLNPKALLEFYSNLPDDIFESGKAAEEKRPLSLSFSDLQDGDCVFTSSSATSPSSSHSAHPEITITPAELTHSSLSSQNEGTEDSSSASSRNSLGEDHEPKSHPKSDTVEPGKPGVATRSGTESLFLESSVAEALLQESDEASELKPVELDTFEGNITKQLVKRLTSAEGPVTTDKLFFEGSVGSESEAGRSFLDGSLEDAFNGLFLALDPHKKQYKEFQDLNQEVTHLDDVLKCKPAGSRSRSSSLSLTVESALESFDFLNTSDFDEEEEDGDDVCHVGGGADSVFSDTETEKSGYRSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVKHLQYCTQLIQQIVFSSKTPFVARSLLEKLSRQVLVMQKLAAVSDENLGNITSVVEAIPEFHKKLSLLAFWTKCCSPSGVYHSSAARLIKQLEASFARSINKDYPGLAEPVFRTLVSQILDRAEPLLSSSLSSEVITVFQYYSFFTSHGVSDLETYLGQLTRQVAMVQTLQSLRDEKLLQTMSDLAPSNLPAQQEVLRTLALLLTRDDNEVSEAVTLYLAAASKNEHFREKALLYYCEALTKANLQLQKAACLALKSLEATESIKMLVTLCQSDTEEIRTVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRHGTEVATAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	LVGSQSFSPGGPNGI EEECCCCCCCCCCCE		22802335
44	Phosphorylation	GPNGIIRSQSFAGFS CCCCEEECCCCCCCC		27566939
46	Phosphorylation	NGIIRSQSFAGFSGL CCEEECCCCCCCCCH		25521595
51	Phosphorylation	SQSFAGFSGLQERRS CCCCCCCCCHHHHHH		22802335
58	Phosphorylation	SGLQERRSRCNSFIE CCHHHHHHHHHHHHH		25266776
62	Phosphorylation	ERRSRCNSFIENASA HHHHHHHHHHHHHHH		21082442
68	Phosphorylation	NSFIENASALKKPQA HHHHHHHHHCCCHHH		28833060
194	Phosphorylation	AFATSPASKAARESL HHHCCHHHHHHHHHH		-
200	Phosphorylation	ASKAARESLSEINRS HHHHHHHHHHHHHHH		25266776
211	Phosphorylation	INRSYKEYTENMCAI HHHHHHHHHHHHHHH		-
366	Phosphorylation	AALQRRMSMYSQGTP HHHHHHHHHHCCCCC		21082442
368	Phosphorylation	LQRRMSMYSQGTPET HHHHHHHHCCCCCCC		28833060
369	Phosphorylation	QRRMSMYSQGTPETP HHHHHHHCCCCCCCC		28833060
372	Phosphorylation	MSMYSQGTPETPTFK HHHHCCCCCCCCCCC		28833060
375	Phosphorylation	YSQGTPETPTFKDQS HCCCCCCCCCCCCHH		28833060
508	Phosphorylation	SSASSRNSLGEDHEP CCCHHCCCCCCCCCC		24704852
581	Phosphorylation	KQLVKRLTSAEGPVT HHHHHHHHCCCCCCC		27149854
582	Phosphorylation	QLVKRLTSAEGPVTT HHHHHHHCCCCCCCC		25521595
588	Phosphorylation	TSAEGPVTTDKLFFE HCCCCCCCCCEEEEE		28833060
600	Phosphorylation	FFEGSVGSESEAGRS EEECCCCCCCHHHHH		28285833
602	Phosphorylation	EGSVGSESEAGRSFL ECCCCCCCHHHHHHC		28833060
607	Phosphorylation	SESEAGRSFLDGSLE CCCHHHHHHCCCCHH		26745281
612	Phosphorylation	GRSFLDGSLEDAFNG HHHHCCCCHHHHHHC		26745281
928	Phosphorylation	AMVQTLQSLRDEKLL HHHHHHHHHCHHHHH		28973931
1025	Phosphorylation	ESIKMLVTLCQSDTE HHHHHHHHHHCCCHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
46	S	Phosphorylation	Kinase	PINK1	Q9BXM7	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIPR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIPR2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYSF_MOUSE	Dysf	physical	24687993

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.