dbPTM

NPHP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NPHP4_MOUSE
UniProt AC	P59240
Protein Name	Nephrocystin-4
Gene Name	Nphp4
Organism	Mus musculus (Mouse).
Sequence Length	1425
Subcellular Localization	Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, tight junction . In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it ac
Protein Description	Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (By similarity). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (By similarity)..
Protein Sequence	MGDWHRAFTQNTLVPPHPQRARQLGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGTLQLLSCGFGILRIFGNKPESPTSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMRLMENCSLQYTLKPHPPLEPAFHLLPENLLVSGFQQIPGLLPPHGDTGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDREGVGLLDSGTLEVLERRLHVCVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKISASSKNSSGNQALVLRSHLRLPEMVSHPAFAIVFQLEYVFNSPSGADGGASSPTSISSVACMHMVRWAVWNPDLEVGPGKVTLPLQGGVQQNPSRCLVYKVPSASMSSEEVKQVESGTIQFQFSLSSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLTASPLSPALQSSSKPPLQPPDSSQSPEGPQLQAESVLESRVSHLEADLSQPASLQGTPAVEHLQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDASQQPVEAVNPIDPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWPQTVYFTFQFYRFPPETTPRLQLVKLDGTGKSGSGSLSHILVPINKDGSFDAGSPGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLIGSAGVQMKHLLRQGRPAVQVSHELEVVATEYEQEMMAVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHACEPRARGSNLLPPSRSRVISNDGASFFSGGSLLIPGGPKRKRVVQAQRLADVDSELAAMLLTHTRAGQGPQAAGQEADAVHKRKLERMRLVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRGSLAPQLYLRPRETAHIPLKFQSFSVGPLAPTQAPAEVITEKDAESGPLWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFVHLNLVDIDYHQLVASWLVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDHEDKNEETFCVKVLYQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GDWHRAFTQNTLVPP CCHHHCCCCCCCCCC	21.66	23608596
145	Phosphorylation	IFGNKPESPTSAAQD ECCCCCCCCCCHHHH	41.84	26824392
147	Phosphorylation	GNKPESPTSAAQDKR CCCCCCCCCHHHHHH	40.03	29472430
148	Phosphorylation	NKPESPTSAAQDKRL CCCCCCCCHHHHHHH	25.62	29472430
320	Phosphorylation	VALTRSASFSRKISA EEECCCHHHHCCCCC	25.63	24719451
332	Phosphorylation	ISASSKNSSGNQALV CCCCCCCCCCCCEEE	43.27	27841257
475	Phosphorylation	SSRKMPASPSGTPAP CCCCCCCCCCCCCCC	17.46	26239621
477	Phosphorylation	RKMPASPSGTPAPAA CCCCCCCCCCCCCHH	53.45	26239621
479	Phosphorylation	MPASPSGTPAPAARD CCCCCCCCCCCHHHH	22.18	26239621
634	Phosphorylation	FNPQKEESDCLRGNE CCCCCCCCCCCCCCH	34.41	24719451
686	Acetylation	TPRLQLVKLDGTGKS CCCEEEEEECCCCCC	49.83	19853455
1248	Phosphorylation	AGQLTRLSLVLRGTQ HHHHHHHHHHHCCCC	17.09	24719451
1345	Phosphorylation	AAGDEKGTNKRITYT CCCCCCCCCCCEEEC	48.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NPHP4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NPHP4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NPHP4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRT82_MOUSE	Krt82	physical	21565611
KRT35_MOUSE	Krt35	physical	21565611
K1C16_MOUSE	Krt16	physical	21565611
MYO1C_MOUSE	Myo1c	physical	21565611
SRC8_MOUSE	Cttn	physical	21565611
TBA1B_MOUSE	Tuba1b	physical	21565611
NPHP1_MOUSE	Nphp1	physical	21565611
DSG1A_MOUSE	Dsg1a	physical	21565611
FLNC_MOUSE	Flnc	physical	21565611
LIMA1_MOUSE	Lima1	physical	21565611
MYH9_MOUSE	Myh9	physical	21565611
DESP_MOUSE	Dsp	physical	21565611
K2C73_MOUSE	Krt73	physical	21565611
VIME_MOUSE	Vim	physical	21565611
K1C42_MOUSE	Krt42	physical	21565611
MYH10_MOUSE	Myh10	physical	21565611
K2C1_MOUSE	Krt1	physical	21565611
KRT86_MOUSE	Krt86	physical	21565611
K1C10_MOUSE	Krt10	physical	21565611
ANXA2_MOUSE	Anxa2	physical	21565611
GRP78_MOUSE	Hspa5	physical	21565611
ANXA1_MOUSE	Anxa1	physical	21565611
TBB4B_MOUSE	Tubb4b	physical	21565611
FLNB_MOUSE	Flnb	physical	21565611
K1C15_MOUSE	Krt15	physical	21565611
K22E_MOUSE	Krt2	physical	21565611
PLEC_MOUSE	Plec	physical	21565611
KT33B_MOUSE	Krt33b	physical	21565611
FTM_MOUSE	Rpgrip1l	physical	21565611
PLAK_MOUSE	Jup	physical	21565611
RINI_MOUSE	Rnh1	physical	21565611
K2C5_MOUSE	Krt5	physical	21565611
HS90B_MOUSE	Hsp90ab1	physical	21565611
K1C13_MOUSE	Krt13	physical	21565611
SPTB2_MOUSE	Sptbn1	physical	21565611
ML12B_MOUSE	Myl12b	physical	21565611
ACTC_MOUSE	Actc1	physical	21565611
ACTN1_MOUSE	Actn1	physical	21565611
GRP75_MOUSE	Hspa9	physical	21565611
DREB_MOUSE	Dbn1	physical	21565611
K2C7_MOUSE	Krt7	physical	21565611
ACTG_MOUSE	Actg1	physical	21565611
FLNA_MOUSE	Flna	physical	21565611
K2C79_MOUSE	Krt79	physical	21565611
DHE3_MOUSE	Glud1	physical	21565611
K1C14_MOUSE	Krt14	physical	21565611
K22O_MOUSE	Krt76	physical	21565611
MYO5A_MOUSE	Myo5a	physical	21565611
GELS_MOUSE	Gsn	physical	21565611
PKP1_MOUSE	Pkp1	physical	21565611
K2C6A_MOUSE	Krt6a	physical	21565611
HSP7C_MOUSE	Hspa8	physical	21565611
ACTB_MOUSE	Actb	physical	21565611
K1C17_MOUSE	Krt17	physical	21565611
RS27A_MOUSE	Rps27a	physical	21565611
K2C1_HUMAN	KRT1	physical	21565611
K2C78_HUMAN	KRT78	physical	21565611
K1C9_HUMAN	KRT9	physical	21565611
K22E_HUMAN	KRT2	physical	21565611
K2C5_HUMAN	KRT5	physical	21565611
K1C10_HUMAN	KRT10	physical	21565611
K1C14_HUMAN	KRT14	physical	21565611
K2C6A_HUMAN	KRT6A	physical	21565611
PCBP3_MOUSE	Pcbp3	physical	21565611
TBB6_MOUSE	Tubb6	physical	21565611
TBB5_MOUSE	Tubb5	physical	21565611
CDK12_MOUSE	Cdk12	physical	21565611
PLD3_MOUSE	Pld3	physical	21565611
IMDH1_MOUSE	Impdh1	physical	21565611
HSPB1_MOUSE	Hspb1	physical	21565611
TRAP1_MOUSE	Trap1	physical	21565611
EPHA2_MOUSE	Epha2	physical	21565611
RBM4_MOUSE	Rbm4	physical	21565611
TSSK4_MOUSE	Tssk4	physical	21565611
ID3_MOUSE	Id3	physical	21565611
MKL2_MOUSE	Mkl2	physical	21565611
FHOD1_MOUSE	Fhod1	physical	21565611
GSDMA_MOUSE	Gsdma	physical	21565611
UBB_MOUSE	Ubb	physical	21565611
ARGI1_MOUSE	Arg1	physical	21565611
HUTH_MOUSE	Hal	physical	21565611
ENPL_MOUSE	Hsp90b1	physical	21565611
CCAR1_MOUSE	Ccar1	physical	21565611
NAV3_MOUSE	Nav3	physical	21565611
SMTN_MOUSE	Smtn	physical	21565611
ABC8B_MOUSE	Abca8b	physical	21565611
HXB9_MOUSE	Hoxb9	physical	21565611
GFAP_MOUSE	Gfap	physical	21565611
ZC3HE_MOUSE	Zc3h14	physical	21565611
PYGL_MOUSE	Pygl	physical	21565611
F161B_MOUSE	Fam161b	physical	21565611
HS90A_MOUSE	Hsp90aa1	physical	21565611
EX3L4_MOUSE	Exoc3l4	physical	21565611
SSRA_MOUSE	Ssr1	physical	21565611
PDE4D_MOUSE	Pde4d	physical	21565611
NID2_MOUSE	Nid2	physical	21565611
NFM_MOUSE	Nefm	physical	21565611
SHAN3_MOUSE	Shank3	physical	21565611
PRKDC_MOUSE	Prkdc	physical	21565611
TTC27_MOUSE	Ttc27	physical	21565611
CADH2_MOUSE	Cdh2	physical	21565611
SPA24_MOUSE	Spata24	physical	21565611
SAC31_MOUSE	Sac3d1	physical	21565611
PITM1_MOUSE	Pitpnm1	physical	21565611
ESYT1_MOUSE	Esyt1	physical	21565611
CALY_MOUSE	Caly	physical	21565611
CH60_MOUSE	Hspd1	physical	21565611
TBA4A_MOUSE	Tuba4a	physical	21565611
F262_MOUSE	Pfkfb2	physical	21565611
ZC11A_MOUSE	Zc3h11a	physical	21565611
CSCL1_MOUSE	Tmem63a	physical	21565611
COQ4_MOUSE	Coq4	physical	21565611
CMC1_MOUSE	Slc25a12	physical	21565611
PROM2_MOUSE	Prom2	physical	21565611
SNAB_MOUSE	Napb	physical	21565611
ACOC_MOUSE	Aco1	physical	21565611
DAB1_MOUSE	Dab1	physical	21565611
ORC1_MOUSE	Orc1	physical	21565611
KIF2C_MOUSE	Kif2c	physical	21565611
PRDX1_MOUSE	Prdx1	physical	21565611
SYYC_MOUSE	Yars	physical	21565611
CAB45_MOUSE	Sdf4	physical	21565611
RPB2_MOUSE	Polr2b	physical	21565611
CDC7_MOUSE	Cdc7	physical	21565611
EP400_MOUSE	Ep400	physical	21565611
CCR9_MOUSE	Ccr9	physical	21565611
NDUA4_MOUSE	Ndufa4	physical	21565611
CALU_MOUSE	Calu	physical	21565611
ZDH13_MOUSE	Zdhhc13	physical	21565611
ERI1_MOUSE	Eri1	physical	21565611
RBPMS_MOUSE	Rbpms	physical	21565611
AMFR_MOUSE	Amfr	physical	21565611
CRYAB_MOUSE	Cryab	physical	21565611
RCN2_MOUSE	Rcn2	physical	21565611
PKD1_MOUSE	Pkd1	physical	21565611
NUP93_MOUSE	Nup93	physical	21565611
FEM1C_MOUSE	Fem1c	physical	21565611
FRRS1_MOUSE	Frrs1	physical	21565611
ZSWM5_MOUSE	Zswim5	physical	21565611
SRSF2_MOUSE	Srsf2	physical	21565611
SIK3_MOUSE	Sik3	physical	21565611
RSRC1_MOUSE	Rsrc1	physical	21565611
VP13C_MOUSE	Vps13c	physical	21565611
LIN54_MOUSE	Lin54	physical	21565611
K1C20_MOUSE	Krt20	physical	21565611
ACTA_MOUSE	Acta2	physical	21565611
THIM_MOUSE	Acaa2	physical	21565611
RGPA2_MOUSE	Ralgapa2	physical	21565611
AN13B_MOUSE	Ankrd13b	physical	21565611
MYPC2_MOUSE	Mybpc2	physical	21565611
ANGL6_MOUSE	Angptl6	physical	21565611
CE042_MOUSE	2410089E03Rik	physical	21565611
YETS2_MOUSE	Yeats2	physical	21565611
ABC8A_MOUSE	Abca8a	physical	21565611
HNRPF_MOUSE	Hnrnpf	physical	21565611
BAG2_MOUSE	Bag2	physical	21565611
DNAL1_MOUSE	Dnal1	physical	21565611
GUC2C_MOUSE	Gucy2c	physical	21565611
TR150_MOUSE	Thrap3	physical	21565611
SMDC1_MOUSE	Saysd1	physical	21565611
DDX28_MOUSE	Ddx28	physical	21565611
OSR1_MOUSE	Osr1	physical	21565611
FXL13_MOUSE	Fbxl13	physical	21565611
K2C8_MOUSE	Krt8	physical	21565611
GL1D1_MOUSE	Glt1d1	physical	21565611
PAR6G_MOUSE	Pard6g	physical	21565611
CNTRL_MOUSE	Cntrl	physical	21565611
TBB2A_MOUSE	Tubb2a	physical	21565611
HSP72_MOUSE	Hspa2	physical	21565611
NACAM_MOUSE	Naca	physical	21565611
NACA_MOUSE	Naca	physical	21565611
NOL10_MOUSE	Nol10	physical	21565611
TBB3_MOUSE	Tubb3	physical	21565611
CHD4_MOUSE	Chd4	physical	21565611
MED14_MOUSE	Med14	physical	21565611
SPB7_MOUSE	Serpinb7	physical	21565611
K2C1B_MOUSE	Krt77	physical	21565611
CALI_MOUSE	Ccin	physical	21565611
HPCL1_MOUSE	Hpcal1	physical	21565611
USMG5_MOUSE	Usmg5	physical	21565611
EMAL3_MOUSE	Eml3	physical	21565611
TBA1A_MOUSE	Tuba1a	physical	21565611
EPIPL_MOUSE	Eppk1	physical	21565611

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NPHP4_MOUSE

Related Literatures of Post-Translational Modification