MYPC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYPC2_MOUSE
• UniProt AC: Q5XKE0
• Protein Name: Myosin-binding protein C, fast-type
• Gene Name: Mybpc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1136
• Protein Description: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity)..
• Protein Sequence: MPEAKPAAKKASKGKDAPKEAPAKQTPEEPPKEAPPEDQSPTAEEPTGIFLKKPDSVSVETGKDAVILAKVNGKELPGKPTIKWFKGKWQELGSKSGARFIFKESHDSTSNVYTVELHIGKVVLGDRGDYRLEIKAKDVCDSCSFNVDVEAPRQDSSGQSLESFKRSGDGKSEDAGELDFSGLLKKREVVEEEKKKKKDDDDLGIPPEIWELLKGAKKSEYEKIAFQYGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVDRGNKIKLVVEISDPDLPLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVQDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMSVEVSEEGAQVMWMKDGVEMTREDSYKARYRFKKDGKRHILIYSDVAQEDGGRYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKAAEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSDNSIVVVAGNKLRLDVAITGEPPPTATWLRGDEVFTATEGRTHIEQRPDCSSFVIESAERSDEGRYTIKVTNPVGEDVASIFLRVVDVPDPPEAVRVTSVGEDWAILVWEPPKYDGGQPVTGYLMERKKKGSQRWMKINFEVFTDTTYESTKMIEGVLYEMRVFAVNAIGVSQPSMNTKPFMPIAPTSAPQHLTVEDVTDTTTTLKWRPPDRIGAGGIDGYLVEYCLEGSEEWVPANKEPVERCGFTVKDLPTGARILFRVVGVNIAGRSEPATLLQPVTIREIVEQPKIRLPRHLRQTYIRKVGEALNLVIPFQGKPRPQVVWTKGGAPLDTSRVNVRTSDFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPAENVMVKEVWGTNALVEWQPPKDDGNSEITGYFVQKADKKTMEWFNVYEHNRHTSCTVSDLIVGNEYYFRIFSENICGLSDSPGVSKNTARILKTGITLKPLEYKEHDFRTAPKFLTPLMDRVVVAGYTAALNCAVRGHPKPKVVWMKNKMEIHEDPKFLITNYQGILTLNIRRPSPFDAGTYSCRAFNELGEALAECKLDVRVPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MPEAKPAAKKAS ---CCCCCHHHHHHH	33.26	15609027
9	Acetylation	PEAKPAAKKASKGKD CCCCHHHHHHHCCCC	51.48	15609035
19	Ubiquitination	SKGKDAPKEAPAKQT HCCCCCCCCCCCCCC	69.13	-
24	Ubiquitination	APKEAPAKQTPEEPP CCCCCCCCCCCCCCC	54.36	-
26	Phosphorylation	KEAPAKQTPEEPPKE CCCCCCCCCCCCCCC	31.77	28464351
32	Ubiquitination	QTPEEPPKEAPPEDQ CCCCCCCCCCCCCCC	76.77	-
40	Phosphorylation	EAPPEDQSPTAEEPT CCCCCCCCCCCCCCC	36.22	25521595
42	Phosphorylation	PPEDQSPTAEEPTGI CCCCCCCCCCCCCEE	52.53	28464351
47	Phosphorylation	SPTAEEPTGIFLKKP CCCCCCCCEEEEECC	46.30	28464351
56	Phosphorylation	IFLKKPDSVSVETGK EEEECCCCEEEEECC	25.48	25619855
58	Phosphorylation	LKKPDSVSVETGKDA EECCCCEEEEECCCE	20.42	25619855
61	Phosphorylation	PDSVSVETGKDAVIL CCCEEEEECCCEEEE	47.58	28464351
63	Acetylation	SVSVETGKDAVILAK CEEEEECCCEEEEEE	50.35	15607529
63	Ubiquitination	SVSVETGKDAVILAK CEEEEECCCEEEEEE	50.35	-
74	Acetylation	ILAKVNGKELPGKPT EEEEECCEECCCCCC	51.37	15607537
74	Ubiquitination	ILAKVNGKELPGKPT EEEEECCEECCCCCC	51.37	-
79	Ubiquitination	NGKELPGKPTIKWFK CCEECCCCCCEEEEC	36.73	-
88	Ubiquitination	TIKWFKGKWQELGSK CEEEECCCHHHCCCC	46.42	-
94	Phosphorylation	GKWQELGSKSGARFI CCHHHCCCCCCCEEE	35.95	28542873
95	Ubiquitination	KWQELGSKSGARFIF CHHHCCCCCCCEEEE	51.62	-
108	Phosphorylation	IFKESHDSTSNVYTV EEEECCCCCCCEEEE	28.45	28464351
137	Ubiquitination	YRLEIKAKDVCDSCS EEEEEEEEECCCCCC	45.77	-
144	Phosphorylation	KDVCDSCSFNVDVEA EECCCCCCEECEEEC	24.65	28464351
156	Phosphorylation	VEAPRQDSSGQSLES EECCCCCCCCCCHHH	28.20	28464351
157	Phosphorylation	EAPRQDSSGQSLESF ECCCCCCCCCCHHHH	49.49	22210690
160	Phosphorylation	RQDSSGQSLESFKRS CCCCCCCCHHHHHCC	37.31	22210690
163	Phosphorylation	SSGQSLESFKRSGDG CCCCCHHHHHCCCCC	41.16	22210690
165	Ubiquitination	GQSLESFKRSGDGKS CCCHHHHHCCCCCCC	55.74	-
167	Phosphorylation	SLESFKRSGDGKSED CHHHHHCCCCCCCCC	41.65	28464351
171	Ubiquitination	FKRSGDGKSEDAGEL HHCCCCCCCCCCCCC	56.25	-
172	Phosphorylation	KRSGDGKSEDAGELD HCCCCCCCCCCCCCC	46.36	21183079
185	Ubiquitination	LDFSGLLKKREVVEE CCCHHHHHHHHHHHH	55.62	-
194	Ubiquitination	REVVEEEKKKKKDDD HHHHHHHHHHCCCCC	73.50	-
195	Ubiquitination	EVVEEEKKKKKDDDD HHHHHHHHHCCCCCC	73.44	-
196	Ubiquitination	VVEEEKKKKKDDDDL HHHHHHHHCCCCCCC	75.91	-
197	Ubiquitination	VEEEKKKKKDDDDLG HHHHHHHCCCCCCCC	71.02	-
198	Ubiquitination	EEEKKKKKDDDDLGI HHHHHHCCCCCCCCC	75.23	-
214	Ubiquitination	PEIWELLKGAKKSEY HHHHHHHHCCCHHHH	70.24	-
223	Ubiquitination	AKKSEYEKIAFQYGI CCHHHHHHHHHHHCC	38.13	-
248	Ubiquitination	KKAKVEVKKSAAFTK HHCCCEECCHHHHHC	27.75	-
249	Ubiquitination	KAKVEVKKSAAFTKK HCCCEECCHHHHHCC	50.97	-
256	Ubiquitination	KSAAFTKKLDPAYQV CHHHHHCCCCCCEEE	55.88	-
268	Ubiquitination	YQVDRGNKIKLVVEI EEECCCCEEEEEEEE	44.00	-
283	Ubiquitination	SDPDLPLKWFKNGQE CCCCCCCHHEECCEE	48.95	-
286	Ubiquitination	DLPLKWFKNGQEIKP CCCCHHEECCEECCC	60.08	-
294	Phosphorylation	NGQEIKPSSKYVFEN CCEECCCCCCEEEEE	34.16	22210690
295	Phosphorylation	GQEIKPSSKYVFENV CEECCCCCCEEEEEC	36.21	23375375
297	Phosphorylation	EIKPSSKYVFENVGK ECCCCCCEEEEECCC	16.60	28464351
304	Ubiquitination	YVFENVGKKRILTIN EEEEECCCCEEEEEE	34.30	-
309	Phosphorylation	VGKKRILTINKCTLA CCCCEEEEEECCCCC	21.82	21183079
312	Ubiquitination	KRILTINKCTLADDA CEEEEEECCCCCCCH	25.42	-
314	Phosphorylation	ILTINKCTLADDAAY EEEEECCCCCCCHHH	26.96	28464351
321	Phosphorylation	TLADDAAYEVAVQDE CCCCCHHHHHHCCCC	16.80	28978645
385	Phosphorylation	VEMTREDSYKARYRF EEECCCHHHHEEEEE	24.63	28464351
387	Ubiquitination	MTREDSYKARYRFKK ECCCHHHHEEEEECC	30.27	-
403	Phosphorylation	GKRHILIYSDVAQED CCEEEEEEEECEECC	8.72	22210690
404	Phosphorylation	KRHILIYSDVAQEDG CEEEEEEEECEECCC	20.72	24723360
467	Phosphorylation	EKVTGKWYKNGVEVR CCCCCEEEECCEEEC	9.69	-
468	Ubiquitination	KVTGKWYKNGVEVRP CCCCEEEECCEEECC	46.22	-
476	Phosphorylation	NGVEVRPSKRITISH CCEEECCCCCEEECC	24.81	28464351
477	Acetylation	GVEVRPSKRITISHV CEEECCCCCEEECCC	50.97	19863629
480	Phosphorylation	VRPSKRITISHVGRF ECCCCCEEECCCCCE	22.06	28542873
482	Phosphorylation	PSKRITISHVGRFHK CCCCEEECCCCCEEE	11.94	24719451
530	Acetylation	IKVEYVPKQEPPKIH EEEEECCCCCCCCEE	58.19	19863637
541	Phosphorylation	PKIHLDCSGKTSDNS CCEEEECCCCCCCCE	42.88	28542873
544	Phosphorylation	HLDCSGKTSDNSIVV EEECCCCCCCCEEEE	44.85	28464351
545	Phosphorylation	LDCSGKTSDNSIVVV EECCCCCCCCEEEEE	37.98	28464351
548	Phosphorylation	SGKTSDNSIVVVAGN CCCCCCCEEEEEECC	23.04	28464351
564	Phosphorylation	LRLDVAITGEPPPTA EEEEEEECCCCCCCC	26.25	28542873
581	Phosphorylation	LRGDEVFTATEGRTH ECCCEEEEECCCCCC	37.53	28464351
583	Phosphorylation	GDEVFTATEGRTHIE CCEEEEECCCCCCEE	35.60	28542873
602	Phosphorylation	CSSFVIESAERSDEG CCCEEEEECCCCCCC	25.06	28464351
606	Phosphorylation	VIESAERSDEGRYTI EEEECCCCCCCCEEE	31.36	28464351
616	Phosphorylation	GRYTIKVTNPVGEDV CCEEEEEECCCCCCC	28.89	28542873
717	Phosphorylation	AVNAIGVSQPSMNTK EEEEEECCCCCCCCC	31.03	25367039
720	Phosphorylation	AIGVSQPSMNTKPFM EEECCCCCCCCCCCC	19.61	25367039
723	Phosphorylation	VSQPSMNTKPFMPIA CCCCCCCCCCCCCCC	31.30	25367039
732	Phosphorylation	PFMPIAPTSAPQHLT CCCCCCCCCCCCCEE	28.62	25367039
733	Phosphorylation	FMPIAPTSAPQHLTV CCCCCCCCCCCCEEE	36.57	25367039
739	Phosphorylation	TSAPQHLTVEDVTDT CCCCCCEEEECCCCC	21.52	25367039
744	Phosphorylation	HLTVEDVTDTTTTLK CEEEECCCCCCCEEE	39.69	22210690
746	Phosphorylation	TVEDVTDTTTTLKWR EEECCCCCCCEEEEC	19.37	22210690
747	Phosphorylation	VEDVTDTTTTLKWRP EECCCCCCCEEEECC	22.16	22210690
748	Phosphorylation	EDVTDTTTTLKWRPP ECCCCCCCEEEECCC	32.02	22210690
749	Phosphorylation	DVTDTTTTLKWRPPD CCCCCCCEEEECCCC	25.01	25367039
770	Phosphorylation	IDGYLVEYCLEGSEE CCCEEEEHHHCCCCC	8.54	-
819	Phosphorylation	AGRSEPATLLQPVTI CCCCCCCCCCCCEEH	38.42	28464351
825	Phosphorylation	ATLLQPVTIREIVEQ CCCCCCEEHHHHHHC	22.47	28464351
844	Phosphorylation	LPRHLRQTYIRKVGE CCHHHHHHHHHHHHH	17.93	28542873
845	Phosphorylation	PRHLRQTYIRKVGEA CHHHHHHHHHHHHHH	7.15	28542873
878	Phosphorylation	KGGAPLDTSRVNVRT ECCCCCCCCCEECCC	26.56	28464351
879	Phosphorylation	GGAPLDTSRVNVRTS CCCCCCCCCEECCCC	33.62	28464351
900	Phosphorylation	FVRQAARSDSGEYEL EEEEEHHCCCCEEEE	31.25	28464351
902	Phosphorylation	RQAARSDSGEYELSV EEEHHCCCCEEEEEE	34.47	28464351
978	Phosphorylation	TMEWFNVYEHNRHTS EEEEEECCCCCCCCE	16.75	-
997	Phosphorylation	DLIVGNEYYFRIFSE HEEECCCEEEEEECC	16.35	28576409
998	Phosphorylation	LIVGNEYYFRIFSEN EEECCCEEEEEECCC	4.72	28576409
1010	Phosphorylation	SENICGLSDSPGVSK CCCCCCCCCCCCCCH	22.71	22210690
1012	Phosphorylation	NICGLSDSPGVSKNT CCCCCCCCCCCCHHH	21.85	22210690
1016	Phosphorylation	LSDSPGVSKNTARIL CCCCCCCCHHHHHHH	26.55	22210690
1017	Ubiquitination	SDSPGVSKNTARILK CCCCCCCHHHHHHHH	56.78	-
1019	Phosphorylation	SPGVSKNTARILKTG CCCCCHHHHHHHHCC	22.50	22210690
1028	Phosphorylation	RILKTGITLKPLEYK HHHHCCCEECCCCCC	30.03	-
1044	Ubiquitination	HDFRTAPKFLTPLMD CCCCCCHHHHHHHHH	51.01	-
1078	Ubiquitination	KPKVVWMKNKMEIHE CCEEEEECCCEECCC	37.39	-
1106	Phosphorylation	TLNIRRPSPFDAGTY EEEECCCCCCCCCCC	36.07	21183079
1112	Phosphorylation	PSPFDAGTYSCRAFN CCCCCCCCCCHHHHH	17.62	21183079
1113	Phosphorylation	SPFDAGTYSCRAFNE CCCCCCCCCHHHHHH	12.59	21183079
1114	Phosphorylation	PFDAGTYSCRAFNEL CCCCCCCCHHHHHHH	9.28	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Trim63	Q38HM4	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYPC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYPC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYPC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.