SMTN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMTN_MOUSE
• UniProt AC: Q921U8
• Protein Name: Smoothelin
• Gene Name: Smtn
• Organism: Mus musculus (Mouse).
• Sequence Length: 923
• Subcellular Localization: Cytoplasm, cytoskeleton. Exhibits a filamentous organization..
• Protein Description: Structural protein of the cytoskeleton..
• Protein Sequence: MADEALAGLDEGALRKLLEVTADLAERRRIRSAIRELQRQELEREEEALASKRFRAERQDNKENWLHSQQREAEQQAALARLAGRLESMNDVEELTTLLRSAGEYEERKLIRAAIRRVRAQEIKAATLAGRLCSRLPSSGPREDSRRQAAHTLDPGKVPEPEQQEQQTEVLEPTPTPEDTSQDVTTVTLLLRAPPGGRPSSPASPHNSPTSASPEPLLEPAGAQCPAVEAPVSSEPLPHPSEAPSPEPPMSPVPSSSRGRVISKPLPGPTEPSDTLDSIRGFSNTKRADPSETKSCQRSLSVLSPRQPTPNREPTSLAGPSQFRRVGSVRDRVQKFTSDSPVVARLQDGPPRTALASPTPTRLPGPSLISTTPASSSSSNSSSPSPSDTSSHKKQRELAHSLAELQSCPQEEGPGGRGLALRSLENRAGGPKPCSEEPSTPPPVAVGTGEPGGSMKTTFTIEIKDGRGQASTGRVLLPTGNQRAELTLGLRAPPTLLSTSSGGKNTITHISNPGTVTRLGSVTHVTTFSHASPGNRGGCNFKMEPDPAEPPSTTVEAANGAEQARVDKGPEGRSPLSAEELTAIEDEGVLDKMLDQTTNFEERKLIRAALRELRQRKRDQRDKERERRLREARARPGESRSNVATETTTRHSQRAADGSTVGTVTKTERLVHSNDGTQTARTTTVESSFMRRLENGSSSSSTTTTTVQTKSFSSSSSSSSSKKMGSIFDREDQTSSRPGSLAALERRQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGSAGGPGTPRTAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEMAFSSAEMLVDCVPLVEVEDMMIMGKKPDPKCVFTYVQSLYNHLRRHELRLRGKNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADEALAGL ------CHHHHHHCC	24.29	-
32	Phosphorylation	AERRRIRSAIRELQR HHHHHHHHHHHHHHH	26.19	28059163
52	Ubiquitination	EEEALASKRFRAERQ HHHHHHHHHHHHHHH	50.37	-
68	Phosphorylation	NKENWLHSQQREAEQ HHHHHHHHHHHHHHH	26.32	-
127	Phosphorylation	AQEIKAATLAGRLCS HHHHHHHHHHHHHHH	23.23	20139300
138	Phosphorylation	RLCSRLPSSGPREDS HHHHCCCCCCCCHHH	53.14	24719451
299	Phosphorylation	ETKSCQRSLSVLSPR HCCHHHHHHHCCCCC	10.10	29472430
301	Phosphorylation	KSCQRSLSVLSPRQP CHHHHHHHCCCCCCC	23.43	27180971
304	Phosphorylation	QRSLSVLSPRQPTPN HHHHHCCCCCCCCCC	18.84	26824392
309	Phosphorylation	VLSPRQPTPNREPTS CCCCCCCCCCCCCCC	25.51	28507225
328	Phosphorylation	SQFRRVGSVRDRVQK HHHEECCCHHHHHHH	15.89	27149854
337	Phosphorylation	RDRVQKFTSDSPVVA HHHHHHHCCCCCCEE	38.36	23984901
338	Phosphorylation	DRVQKFTSDSPVVAR HHHHHHCCCCCCEEE	38.94	28066266
340	Phosphorylation	VQKFTSDSPVVARLQ HHHHCCCCCCEEECC	21.25	29514104
357	Phosphorylation	PPRTALASPTPTRLP CCCCCCCCCCCCCCC	30.11	26824392
359	Phosphorylation	RTALASPTPTRLPGP CCCCCCCCCCCCCCC	34.49	28066266
361	Phosphorylation	ALASPTPTRLPGPSL CCCCCCCCCCCCCCC	47.52	29472430
372 (in isoform 2)	Phosphorylation	-	15.29	-
372	Phosphorylation	GPSLISTTPASSSSS CCCCEECCCCCCCCC	15.29	-
383	Phosphorylation	SSSSNSSSPSPSDTS CCCCCCCCCCCCCCC	29.26	28973931
435	Phosphorylation	AGGPKPCSEEPSTPP CCCCCCCCCCCCCCC	54.22	25619855
439	Phosphorylation	KPCSEEPSTPPPVAV CCCCCCCCCCCCEEE	57.75	25619855
440	Phosphorylation	PCSEEPSTPPPVAVG CCCCCCCCCCCEEEE	51.00	26824392
448	Phosphorylation	PPPVAVGTGEPGGSM CCCEEEECCCCCCCC	31.60	25619855
454	Phosphorylation	GTGEPGGSMKTTFTI ECCCCCCCCEEEEEE	24.03	25619855
487	Phosphorylation	GNQRAELTLGLRAPP CCCCEEEEEECCCCC	15.41	-
501	Phosphorylation	PTLLSTSSGGKNTIT CCEEECCCCCCCEEE	52.21	-
521	Phosphorylation	GTVTRLGSVTHVTTF CCEEEEEEEEEEEEE	28.56	26824392
523	Phosphorylation	VTRLGSVTHVTTFSH EEEEEEEEEEEEECC	16.60	23984901
526	Phosphorylation	LGSVTHVTTFSHASP EEEEEEEEEECCCCC	17.96	28066266
527	Phosphorylation	GSVTHVTTFSHASPG EEEEEEEEECCCCCC	23.27	28066266
529	Phosphorylation	VTHVTTFSHASPGNR EEEEEEECCCCCCCC	18.95	26643407
532	Phosphorylation	VTTFSHASPGNRGGC EEEECCCCCCCCCCC	28.10	21659605
574	Phosphorylation	DKGPEGRSPLSAEEL CCCCCCCCCCCHHHH	40.84	26239621
577	Phosphorylation	PEGRSPLSAEELTAI CCCCCCCCHHHHHHH	36.70	26239621
582	Phosphorylation	PLSAEELTAIEDEGV CCCHHHHHHHCCCCH	28.95	23984901
641	Phosphorylation	ARPGESRSNVATETT CCCCCCHHCCCCCCC	44.96	19060867
647	Phosphorylation	RSNVATETTTRHSQR HHCCCCCCCCCHHHH	29.16	25338131
667	Phosphorylation	TVGTVTKTERLVHSN EEEEEEECEEEEECC	19.57	28576409
697	Phosphorylation	MRRLENGSSSSSTTT HHHCCCCCCCCCEEE	38.33	21183079
699	Phosphorylation	RLENGSSSSSTTTTT HCCCCCCCCCEEEEE	29.97	21082442
701	Phosphorylation	ENGSSSSSTTTTTVQ CCCCCCCCEEEEEEE	31.55	21082442
711	Phosphorylation	TTTVQTKSFSSSSSS EEEEEEEECCCCCCC	33.48	27149854
713	Phosphorylation	TVQTKSFSSSSSSSS EEEEEECCCCCCCCC	36.08	23737553
714	Phosphorylation	VQTKSFSSSSSSSSS EEEEECCCCCCCCCC	32.03	23737553
715	Phosphorylation	QTKSFSSSSSSSSSK EEEECCCCCCCCCCC	32.80	27149854
716	Phosphorylation	TKSFSSSSSSSSSKK EEECCCCCCCCCCCC	35.87	27149854
717	Phosphorylation	KSFSSSSSSSSSKKM EECCCCCCCCCCCCC	35.87	27149854
718	Phosphorylation	SFSSSSSSSSSKKMG ECCCCCCCCCCCCCC	35.87	27149854
719	Phosphorylation	FSSSSSSSSSKKMGS CCCCCCCCCCCCCCC	40.35	27149854
720	Phosphorylation	SSSSSSSSSKKMGSI CCCCCCCCCCCCCCC	48.39	27149854
721	Phosphorylation	SSSSSSSSKKMGSIF CCCCCCCCCCCCCCC	37.94	27149854
726	Phosphorylation	SSSKKMGSIFDREDQ CCCCCCCCCCCCCCC	19.31	21183079
735	Phosphorylation	FDREDQTSSRPGSLA CCCCCCCCCCCCHHH	20.79	-
760	Phosphorylation	KELMKAQSLPKTSAS HHHHHHHCCCCCCHH	52.04	23737553
779	Acetylation	AMIEKLEKEGSAGGP HHHHHHHHHCCCCCC	77.22	6566799
788	Phosphorylation	GSAGGPGTPRTAVQR CCCCCCCCCCCCHHH	16.84	23375375
791	Phosphorylation	GGPGTPRTAVQRSTS CCCCCCCCCHHHCCC	32.17	23375375
796	Phosphorylation	PRTAVQRSTSFGVPN CCCCHHHCCCCCCCC	16.00	26239621
797	Phosphorylation	RTAVQRSTSFGVPNA CCCHHHCCCCCCCCH	30.20	23737553
798	Phosphorylation	TAVQRSTSFGVPNAN CCHHHCCCCCCCCHH	22.65	25521595
806	Phosphorylation	FGVPNANSIKQMLLD CCCCCHHHHHHHHHH	28.84	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMTN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMTN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMTN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SMTN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.