CNTRL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNTRL_MOUSE
• UniProt AC: A2AL36
• Protein Name: Centriolin
• Gene Name: Cntrl
• Organism: Mus musculus (Mouse).
• Sequence Length: 2334
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody, Midbody ring .
• Protein Description: Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity)..
• Protein Sequence: MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	SLRSSMRSRSLSPLI HHHHHHHHCCCCCCC	19.99	25293948
34	Phosphorylation	RSSMRSRSLSPLIGS HHHHHHCCCCCCCCC	34.15	25293948
36	Phosphorylation	SMRSRSLSPLIGSET HHHHCCCCCCCCCCC	20.93	25293948
41	Phosphorylation	SLSPLIGSETQPLHP CCCCCCCCCCCCCCC	30.40	25293948
43	Phosphorylation	SPLIGSETQPLHPGG CCCCCCCCCCCCCCC	36.86	25293948
59	Phosphorylation	WPAQAELTDESTVPL CCCCEEECCCCCCCC	29.26	25293948
62	Phosphorylation	QAELTDESTVPLEPQ CEEECCCCCCCCCHH	37.20	25293948
63	Phosphorylation	AELTDESTVPLEPQQ EEECCCCCCCCCHHH	24.89	25293948
117	Phosphorylation	DGGKKFRYIENLEKC CCCCCCHHCCCHHHH	18.73	19367708
400	Phosphorylation	YKRNMFATETYIVSD CCCCCCCCEEEEECH	20.00	25777480
402	Phosphorylation	RNMFATETYIVSDAQ CCCCCCEEEEECHHH	17.75	25777480
403	Phosphorylation	NMFATETYIVSDAQA CCCCCEEEEECHHHH	7.97	25777480
406	Phosphorylation	ATETYIVSDAQAVQI CCEEEEECHHHHHHH	20.05	25777480
428	Phosphorylation	GQLRHEHTPPRVQAP CCCCCCCCCCCCCCC	31.81	21183079
784	Phosphorylation	KQLQDDNSLLKKQLK HHHHCCHHHHHHHHH	41.91	27566939
832	Phosphorylation	AGEMRIHSPSDVLGK CCCCCCCCHHHHHCH	24.59	22942356
834	Phosphorylation	EMRIHSPSDVLGKSL CCCCCCHHHHHCHHH	43.28	26745281
1038	Phosphorylation	MQAAKDLSRAEAEIE HHHHHHHHHHHHHHH	39.31	26643407
1107	Phosphorylation	LNLTGAGTKGGIENV HHHCCCCCCCCHHHH	26.44	29109428
1176	Phosphorylation	LGLKYTASTPLRKPQ CCCEEEECCCCCCCC	23.82	25293948
1177	Phosphorylation	GLKYTASTPLRKPQP CCEEEECCCCCCCCC	24.71	25293948
1205	Phosphorylation	ASGYWVYSPIRSTLH CCCEEEEECHHHHHH	12.30	22067460
1351	Phosphorylation	EERRQKASTQHSEEE HHHHHHHHHCCCHHH	35.32	29550500
1352	Phosphorylation	ERRQKASTQHSEEEV HHHHHHHHCCCHHHH	34.85	22817900
1355	Phosphorylation	QKASTQHSEEEVDGL HHHHHCCCHHHHHHH	36.56	24704852
1478	Phosphorylation	RNLLQTESDAEALEK HHHCCCHHHHHHHHH	45.57	-
1871	Phosphorylation	GKQEAINSLQEELDS HHHHHHHHHHHHHHC	25.89	30635358
1878	Phosphorylation	SLQEELDSTQDHLDL HHHHHHHCHHHHHHH	40.36	30635358
1879	Phosphorylation	LQEELDSTQDHLDLA HHHHHHCHHHHHHHH	37.37	30635358
2041	Phosphorylation	EQQLMAKSGELLALQ HHHHHHHHHHHHHHH	28.14	22067460
2059	Phosphorylation	DDMRADFSLLRNQFL HHHHHHHHHHHHHHH	27.35	-
2174	Phosphorylation	VKDEIRTSLRNLNQF HHHHHHHHHHHHHHH	18.58	28285833

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNTRL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNTRL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNTRL_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CNTRL_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.