K2C7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C7_MOUSE
• UniProt AC: Q9DCV7
• Protein Name: Keratin, type II cytoskeletal 7
• Gene Name: Krt7 {ECO:0000312|MGI:MGI:96704}
• Organism: Mus musculus (Mouse).
• Sequence Length: 457
• Protein Description: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells..
• Protein Sequence: MSIHFSSRSTAYPGRGAQVRLSSGRASFGSRSLYGLGSSRPRVAVRSAYGGPVGAGIREITINQSLLAPLSVDIDPTIQQVRQEEREQIKTLNNKFASFIDKVRFLEQQNKMLETKWALLQEQKSAKSSQLPRIFEAQIAGLRQQLETLQLDGGRLEVELRNMQDVVEDFKNKYEEEINRRTAAENEFVLLKKDVDAAYTNKVELEAKADSLQDEINFLKTLHETELAELQSQISDTSVVLSMDNSRSLDLDGIIADVKAQYEEMANHSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEIAEMNRSIQRLQAEIDTLKNQRAKLESSIAEAEEQGELAIKDAHAKQGELEAALQKAKQDVARQLREYQELLNTKLALDIEIATYRKLLEGEESRLSGDGMGPVNISVVNSTGGNGGKLIFGGTMGSNALSFSGGPGALRAYSIKTTSTTRRGTHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSIHFSSRS ------CCCCCCCCC	25.44	-
2	Phosphorylation	------MSIHFSSRS ------CCCCCCCCC	25.44	20531401
9	Phosphorylation	SIHFSSRSTAYPGRG CCCCCCCCCCCCCCC	21.24	22817900
15	Methylation	RSTAYPGRGAQVRLS CCCCCCCCCCEEEEC	32.54	12229513
20	Methylation	PGRGAQVRLSSGRAS CCCCCEEEECCCCCC	19.44	16288057
23	Phosphorylation	GAQVRLSSGRASFGS CCEEEECCCCCCCCC	36.57	26239621
27	Phosphorylation	RLSSGRASFGSRSLY EECCCCCCCCCCCCC	28.87	26239621
30	Phosphorylation	SGRASFGSRSLYGLG CCCCCCCCCCCCCCC	19.38	26239621
32	Phosphorylation	RASFGSRSLYGLGSS CCCCCCCCCCCCCCC	27.86	27087446
34	Phosphorylation	SFGSRSLYGLGSSRP CCCCCCCCCCCCCCC	16.14	26239621
38	Phosphorylation	RSLYGLGSSRPRVAV CCCCCCCCCCCEEEE	28.37	18846507
39	Phosphorylation	SLYGLGSSRPRVAVR CCCCCCCCCCEEEEE	44.50	20139300
47	Phosphorylation	RPRVAVRSAYGGPVG CCEEEEECCCCCCCC	21.17	22817900
49	Phosphorylation	RVAVRSAYGGPVGAG EEEEECCCCCCCCCC	24.70	-
65	Phosphorylation	REITINQSLLAPLSV EEEEECCHHHCCCCC	22.36	-
71	Phosphorylation	QSLLAPLSVDIDPTI CHHHCCCCCCCCHHH	19.38	27087446
91	Phosphorylation	EEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	29899451
95	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	22790023
98	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22817900
102	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	22790023
111	Ubiquitination	RFLEQQNKMLETKWA HHHHHHHHHHHHHHH	40.29	-
173	Acetylation	VVEDFKNKYEEEINR HHHHHHHHHHHHHHH	55.41	-
199	Phosphorylation	KKDVDAAYTNKVELE ECCCCHHHCCCEEHH	16.74	25195567
211	Phosphorylation	ELEAKADSLQDEINF EHHHHHHHHHHHHHH	32.56	26239621
237	Phosphorylation	LQSQISDTSVVLSMD HHHHHCCCEEEEEEC	19.34	23140645
238	Phosphorylation	QSQISDTSVVLSMDN HHHHCCCEEEEEECC	18.41	23140645
242	Phosphorylation	SDTSVVLSMDNSRSL CCCEEEEEECCCCCC	16.69	29472430
246	Phosphorylation	VVLSMDNSRSLDLDG EEEEECCCCCCCCCC	20.98	28973931
248	Phosphorylation	LSMDNSRSLDLDGII EEECCCCCCCCCCCH	26.51	26239621
269	Phosphorylation	YEEMANHSRAEAEAW HHHHHCCCHHHHHHH	32.75	28973931
283	Phosphorylation	WYQTKFETLQAQAGK HHHHHHHHHHHHCCC	27.57	-
320	Ubiquitination	QAEIDTLKNQRAKLE HHHHHHHHHHHHHHH	53.80	22790023
329	Phosphorylation	QRAKLESSIAEAEEQ HHHHHHHHHHHHHHH	19.22	28973931
388	Ubiquitination	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	27667366
395	Phosphorylation	KLLEGEESRLSGDGM HHHCCCCCCCCCCCC	33.93	26239621
398	Phosphorylation	EGEESRLSGDGMGPV CCCCCCCCCCCCCCE	33.46	23984901
428	Phosphorylation	IFGGTMGSNALSFSG EEECCCCCCCEECCC	14.22	26239621
432	Phosphorylation	TMGSNALSFSGGPGA CCCCCCEECCCCCCC	18.24	26239621
434	Phosphorylation	GSNALSFSGGPGALR CCCCEECCCCCCCEE	39.19	26239621
443	Phosphorylation	GPGALRAYSIKTTST CCCCEEEEEEEECCC	12.42	20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	R	Methylation	Arg-15 is dimethylated, probably to asymmetric dimethylarginine.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.