TBB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBB3_MOUSE
• UniProt AC: Q9ERD7
• Protein Name: Tubulin beta-3 chain
• Gene Name: Tubb3
• Organism: Mus musculus (Mouse).
• Sequence Length: 450
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance..
• Protein Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDDEESEAQGPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	S-nitrosylation	VHIQAGQCGNQIGAK EEEECCCCCCCHHHH	5.60	22588120
48	Phosphorylation	DLQLERISVYYNEAS CCEEEEEEEEECCCC	15.41	19060867
55	Phosphorylation	SVYYNEASSHKYVPR EEEECCCCCCCCCCE	27.14	29899451
56	Phosphorylation	VYYNEASSHKYVPRA EEECCCCCCCCCCEE	30.92	29899451
58	Ubiquitination	YNEASSHKYVPRAIL ECCCCCCCCCCEEEE	50.30	22790023
72	Phosphorylation	LVDLEPGTMDSVRSG EEECCCCCCHHHHCC	28.64	20415495
75	Phosphorylation	LEPGTMDSVRSGAFG CCCCCCHHHHCCCCC	14.49	22817900
106	Phosphorylation	NNWAKGHYTEGAELV CCCCCCCCCCHHHHH	18.37	26239621
107	Phosphorylation	NWAKGHYTEGAELVD CCCCCCCCCHHHHHH	23.44	26239621
115	Phosphorylation	EGAELVDSVLDVVRK CHHHHHHHHHHHHHH	19.66	27600695
124	S-palmitoylation	LDVVRKECENCDCLQ HHHHHHHCCCCCCCC	5.23	28680068
127	S-palmitoylation	VRKECENCDCLQGFQ HHHHCCCCCCCCCEE	1.50	28680068
156	Methylation	TLLISKVREEYPDRI HHHHHHHHHHCCCCC	34.46	18967095
166	Phosphorylation	YPDRIMNTFSVVPSP CCCCCCCCEECCCCC	10.41	28638064
168	Phosphorylation	DRIMNTFSVVPSPKV CCCCCCEECCCCCCC	21.84	26643407
172	Phosphorylation	NTFSVVPSPKVSDTV CCEECCCCCCCCCCE	26.24	26824392
208	Phosphorylation	CIDNEALYDICFRTL EECHHHHHHHHHHHC	15.43	18563927
216	Ubiquitination	DICFRTLKLATPTYG HHHHHHCCCCCCCCH	35.15	-
222	Phosphorylation	LKLATPTYGDLNHLV CCCCCCCCHHHHHHH	15.17	-
252	Acetylation	QLNADLRKLAVNMVP CCCHHHHHHHHHCCC	48.36	15614923
252	Ubiquitination	QLNADLRKLAVNMVP CCCHHHHHHHHHCCC	48.36	27667366
274	Phosphorylation	MPGFAPLTARGSQQY CCCCCCCCCCCCHHH	17.16	22817900
278	Phosphorylation	APLTARGSQQYRALT CCCCCCCCHHHEEEE	14.46	29899451
285	Phosphorylation	SQQYRALTVPELTQQ CHHHEEEEHHHHHHH	32.79	-
297	Ubiquitination	TQQMFDAKNMMAACD HHHHHCCCHHHHHCC	47.42	-
312	Phosphorylation	PRHGRYLTVATVFRG CCCCCEEEHEEEEEC	10.12	18779572
315	Phosphorylation	GRYLTVATVFRGRMS CCEEEHEEEEECCCC	18.81	18779572
324	Ubiquitination	FRGRMSMKEVDEQML EECCCCHHHHHHHHH	47.48	22790023
335	Phosphorylation	EQMLAIQSKNSSYFV HHHHHHHHCCCCCEE	27.91	29899451
338	Phosphorylation	LAIQSKNSSYFVEWI HHHHHCCCCCEEEEC	30.10	26745281
339	Phosphorylation	AIQSKNSSYFVEWIP HHHHCCCCCEEEECC	31.80	26745281
340	Phosphorylation	IQSKNSSYFVEWIPN HHHCCCCCEEEECCC	16.09	22324799
354	S-nitrosylation	NNVKVAVCDIPPRGL CCEEEEEECCCCCCC	2.57	22588120
362	Ubiquitination	DIPPRGLKMSSTFIG CCCCCCCCCCCCCCC	39.29	22790023
372	Phosphorylation	STFIGNSTAIQELFK CCCCCCHHHHHHHHH	31.60	24759943
379	Acetylation	TAIQELFKRISEQFT HHHHHHHHHHHHHHH	62.54	134111
379	Ubiquitination	TAIQELFKRISEQFT HHHHHHHHHHHHHHH	62.54	22790023
382	Phosphorylation	QELFKRISEQFTAMF HHHHHHHHHHHHHHH	29.40	22817900
386	Phosphorylation	KRISEQFTAMFRRKA HHHHHHHHHHHHHHH	19.53	23684622
438	5-glutamyl polyglutamate	EEEGEMYEDDDEESE HHHCCCCCCCCHHHH	54.37	-
438	Formation of an isopeptide bond	EEEGEMYEDDDEESE HHHCCCCCCCCHHHH	54.37	-
444	Phosphorylation	YEDDDEESEAQGPK- CCCCCHHHHHCCCC-	35.86	12631274

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
172	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot
444	S	Phosphorylation	Kinase	GRK2	P25098	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
172	S	Phosphorylation	Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase.	16371510

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBB3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUA_HUMAN	SNCA	physical	11698390
MAP1B_HUMAN	MAP1B	physical	11698390
SYUB_HUMAN	SNCB	physical	11698390

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.