ESYT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESYT1_MOUSE
• UniProt AC: Q3U7R1
• Protein Name: Extended synaptotagmin-1
• Gene Name: Esyt1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1092
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in respon
• Protein Description: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity)..
• Protein Sequence: MEHSPEEGASPEPSGQPPATDSTRDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPLRIIGVKVHPSQRKDQILLDLNVSYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLTGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPHWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTRESKATYSTNSPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLYMKLVMRILYLDYSEIRFPTVPGAQDWDRESLETGSSVDAPPRPYHTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGKSFRTHVVREDLNPRWNEVFEVIVTSIPGQELEIEVFDKDLDKDDFLGRYKVSLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVFLERAEDLPLRKGTKPPSPYATITVGETSHKTKTVSQSSAPVWEESASFLIRKPHAESLELQVRGEGTGTLGSVSLPLSELLQEDQLCLDHWFALSGQGQVLMRAQLGILVSQHSGVEAHSHSYSHSHSSSSLNDEPEALGGPTHPASPVLEVRHRLTHGDSPSEAPVGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRSTKRKTPQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLMDDRDKGGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEHSPEEG -------CCCCCCCC	44.70	-
4	Phosphorylation	----MEHSPEEGASP ----CCCCCCCCCCC	36.98	24759943
10	Phosphorylation	HSPEEGASPEPSGQP CCCCCCCCCCCCCCC	40.42	30635358
14	Phosphorylation	EGASPEPSGQPPATD CCCCCCCCCCCCCCC	48.69	30635358
20	Phosphorylation	PSGQPPATDSTRDGG CCCCCCCCCCCCCCC	35.94	30482847
22	Phosphorylation	GQPPATDSTRDGGSG CCCCCCCCCCCCCCC	22.46	30482847
111	Phosphorylation	RITAETLYMSHRELP HHCHHHHHHHCCCCC	12.18	28833060
113	Phosphorylation	TAETLYMSHRELPAW CHHHHHHHCCCCCCC	13.06	28833060
179	Acetylation	TRVELGEKPLRIIGV EEEEECCCCEEEEEE	47.78	23954790
314	Phosphorylation	QDVAQLRSPLPRGII HHHHHHCCCCCCHHH	39.10	19255425
339	Ubiquitination	SSKDKYVKGLIEGKS CCCCHHHHHHCCCCC	44.93	22790023
345	Ubiquitination	VKGLIEGKSDPYALV HHHHCCCCCCCCEEE	38.61	22790023
349	Phosphorylation	IEGKSDPYALVRVGT CCCCCCCCEEEEECC	19.98	-
360	Glutathionylation	RVGTQTFCSRVIDEE EECCCHHHHHHCCCC	2.63	24333276
412	Ubiquitination	RMKLDVGKVLQAGVL CCCCCHHHHEEECCC	39.35	-
509	Phosphorylation	RESKATYSTNSPVWE HCCCCCCCCCCHHHH	19.43	30635358
510	Phosphorylation	ESKATYSTNSPVWEE CCCCCCCCCCHHHHH	29.33	30635358
512	Phosphorylation	KATYSTNSPVWEEAF CCCCCCCCHHHHHHH	22.40	30635358
536	Ubiquitination	QELDVQVKDDSRALT CCCCEEECCCHHHHH	38.43	22790023
608	Phosphorylation	AQDWDRESLETGSSV CCCCCHHHCCCCCCC	32.19	21183079
611	Phosphorylation	WDRESLETGSSVDAP CCHHHCCCCCCCCCC	47.89	26060331
613	Phosphorylation	RESLETGSSVDAPPR HHHCCCCCCCCCCCC	34.31	26060331
614	Phosphorylation	ESLETGSSVDAPPRP HHCCCCCCCCCCCCC	25.92	26060331
666	Ubiquitination	GKSDPYVKLKVAGKS CCCCCCEEEEECCEE	36.43	27667366
673	Phosphorylation	KLKVAGKSFRTHVVR EEEECCEEHHHEEEC	21.02	-
803	Phosphorylation	DLPLRKGTKPPSPYA CCCCCCCCCCCCCCC	43.33	22499769
804	Acetylation	LPLRKGTKPPSPYAT CCCCCCCCCCCCCCE	64.70	-
807	Phosphorylation	RKGTKPPSPYATITV CCCCCCCCCCCEEEE	38.78	27742792
809	Phosphorylation	GTKPPSPYATITVGE CCCCCCCCCEEEECC	22.25	23684622
811	Phosphorylation	KPPSPYATITVGETS CCCCCCCEEEECCCC	16.02	22499769
813	Phosphorylation	PSPYATITVGETSHK CCCCCEEEECCCCCC	20.36	22499769
817	Phosphorylation	ATITVGETSHKTKTV CEEEECCCCCCEEEC	30.15	22499769
818	Phosphorylation	TITVGETSHKTKTVS EEEECCCCCCEEECC	20.77	22499769
901	Phosphorylation	AQLGILVSQHSGVEA HHHCEEEECCCCCCC	20.80	22802335
904	Phosphorylation	GILVSQHSGVEAHSH CEEEECCCCCCCCCC	36.58	23649490
910	Phosphorylation	HSGVEAHSHSYSHSH CCCCCCCCCCCCCCC	22.60	22802335
912	Phosphorylation	GVEAHSHSYSHSHSS CCCCCCCCCCCCCCC	31.20	22802335
913	Phosphorylation	VEAHSHSYSHSHSSS CCCCCCCCCCCCCCC	12.65	22802335
914	Phosphorylation	EAHSHSYSHSHSSSS CCCCCCCCCCCCCCC	22.87	22802335
916	Phosphorylation	HSHSYSHSHSSSSLN CCCCCCCCCCCCCCC	21.08	22802335
918	Phosphorylation	HSYSHSHSSSSLNDE CCCCCCCCCCCCCCC	34.62	22802335
919	Phosphorylation	SYSHSHSSSSLNDEP CCCCCCCCCCCCCCC	20.65	22802335
920	Phosphorylation	YSHSHSSSSLNDEPE CCCCCCCCCCCCCCH	41.69	22802335
921	Phosphorylation	SHSHSSSSLNDEPEA CCCCCCCCCCCCCHH	32.89	22802335
933	Phosphorylation	PEALGGPTHPASPVL CHHHCCCCCCCCCCE	43.71	23649490
937	Phosphorylation	GGPTHPASPVLEVRH CCCCCCCCCCEEEEE	21.71	23649490
947	Phosphorylation	LEVRHRLTHGDSPSE EEEEEHHCCCCCCCC	24.62	26824392
951	Phosphorylation	HRLTHGDSPSEAPVG EHHCCCCCCCCCCCC	34.61	26824392
953	Phosphorylation	LTHGDSPSEAPVGPL HCCCCCCCCCCCCCC	50.79	22942356
997	Phosphorylation	GRDLPDPYVSVLLLP CCCCCCCCEEEEECC	16.85	22817900
999	Phosphorylation	DLPDPYVSVLLLPDK CCCCCCEEEEECCCC	10.95	22871156
1009	Phosphorylation	LLPDKNRSTKRKTPQ ECCCCCCCCCCCCCC	47.91	25266776
1010	Phosphorylation	LPDKNRSTKRKTPQK CCCCCCCCCCCCCCC	31.47	25266776
1038	Phosphorylation	WDLPLDGTLRRKLDV ECCCCCCCCEEEEEE	19.43	23140645
1055	Phosphorylation	KSNSSFMSRERELLG CCCCCCHHHHHHHHH	29.04	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
314	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
314	S	Phosphorylation	Kinase	CDK5	P49615	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESYT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESYT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ESYT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.