RBPMS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBPMS_MOUSE
• UniProt AC: Q9WVB0
• Protein Name: RNA-binding protein with multiple splicing
• Gene Name: Rbpms
• Organism: Mus musculus (Mouse).
• Sequence Length: 197
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, P-body . Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress.
• Protein Description: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA..
• Protein Sequence: MNGGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAAFTYPASLHAQMRWIPPSEATSQGWKSRQFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNGGGKAE -------CCCCCCCC	10.70	-
9	Ubiquitination	NGGGKAEKENTPSEA CCCCCCCCCCCCCHH	62.21	-
12	Phosphorylation	GKAEKENTPSEANLQ CCCCCCCCCCHHCCC	29.32	27742792
14	Phosphorylation	AEKENTPSEANLQEE CCCCCCCCHHCCCHH	47.50	25521595
36	Ubiquitination	SGLPLDIKPRELYLL CCCCCCCCHHHEEEE	37.38	22790023
36	Ubiquitination	SGLPLDIKPRELYLL CCCCCCCCHHHEEEE	37.38	22790023
48	Ubiquitination	YLLFRPFKGYEGSLI EEEEECCCCCCCCEE	64.36	-
60	Ubiquitination	SLIKLTSKQPVGFVS CEEEEECCCCEEEEE	54.08	22790023
60	Ubiquitination	SLIKLTSKQPVGFVS CEEEEECCCCEEEEE	54.08	22790023
109	Ubiquitination	NTKMAKNKLVGTPNP CCHHHHCCCCCCCCC	43.79	22790023
109	Ubiquitination	NTKMAKNKLVGTPNP CCHHHHCCCCCCCCC	43.79	22790023
113	Phosphorylation	AKNKLVGTPNPSTPL HHCCCCCCCCCCCCC	16.65	27180971
117	Phosphorylation	LVGTPNPSTPLPNTV CCCCCCCCCCCCCCC	49.66	26239621
118	Phosphorylation	VGTPNPSTPLPNTVP CCCCCCCCCCCCCCC	30.06	26239621
123	Phosphorylation	PSTPLPNTVPQFIAR CCCCCCCCCCHHHHC	33.21	29472430
192	Ubiquitination	EATSQGWKSRQFC-- HHHCCCHHHCCCC--	42.45	22790023
192	Ubiquitination	EATSQGWKSRQFC-- HHHCCCHHHCCCC--	42.45	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBPMS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBPMS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBPMS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RBPMS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.