UniProt ID | NID2_MOUSE | |
---|---|---|
UniProt AC | O88322 | |
Protein Name | Nidogen-2 | |
Gene Name | Nid2 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1403 | |
Subcellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. | |
Protein Description | Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions.. | |
Protein Sequence | MFRDPTAGWLTPPSPLSLLVMLLLLSRVGALRPDELFPYGESWGDQLLPEGDDESSAAVKLAIPLRFYDAQFSSLYVGTNGIISTQDFPRETQYVDDDFPTDFPAIAPFLADIDTSHSRGRILYREDTSGAVLSLAARYVRTGFPLSGSSFTPTHAFLATWEHVGAYEEVSRGAAPSGELNTFQAVLASDESDTYALFLYPANGLQFFGTRPKESYNVQLQLPARVGFCRGEADDLKREALYFSLTNTEQSVKNLYQLSNLGIPGVWAFHIGSRFALDNVRPATVGGDPSTARSSALEHPFSHAAALESYTEDSFHYYDENEEDVEYPPVEPGEAPEGHSRIDVSFNSKADPGLVDVGTSSPGSDRASPWPYPAPGNWPSYRETESASLDPQTKQGRPVGEGEVLDFRDPAELLDQMGTRAPAPPEADAALLTPVNEDLGGRNTQSYPEAGPVPSEPDVPVPPLEGEVLPHYPESGHVPPLRGGKYVIGLEDHVGSNDQVFTYNGANLETCEHSHGRCSQHAFCTDYTTGFCCHCQSRFYGNGKHCLPEGAPHRVNGKVSGRLRVGHIPVHFTDVDLHAYIVGNDGRAYTAISHVPQPAAQALLPVLPIGGLFGWLFALEKPGSENGFSLTGATFVHDVEVTFHPGEERVRITQTAEGLDPENYLSIKTNIEGQVPFIPANFTAHITPYKEFYHYRDSVVTSSSSRSFSLTSGSINQTWSYHIDQNITYQACRHAPRHLAIPATQQLTVDRAFALYSEDEGVLRFAVTNQIGPVEVDSAPVGVNPCYDGSHTCDTTARCHPGTGVDYTCECTPGFQGDGRSCVDVNECATGFHRCGPNSVCVNLVGSYRCECRSGYEFADDQHTCILIAPPPNPCLDGSHTCAPEGQARCIHHGGSSFSCACLPGFIGTGHQCSDVDECAENRCHEAAICYNTPGSFSCRCQPGYRGDGFHCTSDTVPEDSISGLKPCEYQQRYAQTQHAYPGSRIHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVPGTQTPPGSTPPHCGPPPEPTQRPRTVCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGRELQGTRSQPGTRPACIPTVAPPVVRPTPRPDVTPPSVGTFLLYAQGQQIGHLPLNGSRLQKDAARTLLSLHGSIVVGIDYDCRERMVYWTDVAGRTISRASLEAGAEPETIITSGLISPEGLAIDHFRRTMYWTDSGLDKIERAELDGSERKVLFHTDLVNPRAITVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINKDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNHLNYPFSIVSYADHFYHTDWRRDGVISVNKDSGQFTDEFLPEQRSHLYGITAVYPYCPTGRK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
85 | Phosphorylation | GTNGIISTQDFPRET ECCCEEECCCCCCCC | 23.04 | 26239621 | |
129 | Phosphorylation | ILYREDTSGAVLSLA EEEECCCCHHHHHHH | 36.76 | 29109428 | |
345 | Phosphorylation | GHSRIDVSFNSKADP CCCCEEEEECCCCCC | 18.24 | 27180971 | |
348 | Phosphorylation | RIDVSFNSKADPGLV CEEEEECCCCCCCCE | 27.49 | 27180971 | |
361 | Phosphorylation | LVDVGTSSPGSDRAS CEEECCCCCCCCCCC | 32.87 | 25338131 | |
384 | Phosphorylation | NWPSYRETESASLDP CCCCCCCCCCCCCCC | 26.66 | 27180971 | |
386 | Phosphorylation | PSYRETESASLDPQT CCCCCCCCCCCCCCC | 30.49 | 26824392 | |
681 | N-linked_Glycosylation | QVPFIPANFTAHITP CCCCCCCCEEEEECC | 29.46 | 19349973 | |
716 | N-linked_Glycosylation | SLTSGSINQTWSYHI EEECCCCCEEEEEEE | 34.62 | - | |
726 | N-linked_Glycosylation | WSYHIDQNITYQACR EEEEECCCEEHHHHC | 25.48 | - | |
1058 | Phosphorylation | RESLLEHYGGTPRDD HHHHHHHCCCCCCCC | 14.10 | 24719451 | |
1061 | Phosphorylation | LLEHYGGTPRDDQYV HHHHCCCCCCCCCCC | 15.70 | 24719451 | |
1152 | N-linked_Glycosylation | QIGHLPLNGSRLQKD EEECCCCCCHHHHHH | 44.44 | - | |
1248 | Methylation | AELDGSERKVLFHTD EECCCCCCEEEEECC | 35.76 | 16289347 | |
1272 | Phosphorylation | DPIRGNLYWTDWNRE ECCCCCEEEECCCCC | 15.40 | 29899451 | |
1274 | Phosphorylation | IRGNLYWTDWNREAP CCCCEEEECCCCCCC | 19.99 | 25521595 | |
1336 | Methylation | TLPDGTGRRVIQNHL ECCCCCCCHHHHHCC | 29.54 | 24129315 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NID2_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NID2_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NID2_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of NID2_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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N-linked Glycosylation | |
Reference | PubMed |
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-681, AND MASSSPECTROMETRY. |