dbPTM

NID2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NID2_MOUSE
UniProt AC	O88322
Protein Name	Nidogen-2
Gene Name	Nid2
Organism	Mus musculus (Mouse).
Sequence Length	1403
Subcellular Localization	Secreted, extracellular space, extracellular matrix, basement membrane.
Protein Description	Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions..
Protein Sequence	MFRDPTAGWLTPPSPLSLLVMLLLLSRVGALRPDELFPYGESWGDQLLPEGDDESSAAVKLAIPLRFYDAQFSSLYVGTNGIISTQDFPRETQYVDDDFPTDFPAIAPFLADIDTSHSRGRILYREDTSGAVLSLAARYVRTGFPLSGSSFTPTHAFLATWEHVGAYEEVSRGAAPSGELNTFQAVLASDESDTYALFLYPANGLQFFGTRPKESYNVQLQLPARVGFCRGEADDLKREALYFSLTNTEQSVKNLYQLSNLGIPGVWAFHIGSRFALDNVRPATVGGDPSTARSSALEHPFSHAAALESYTEDSFHYYDENEEDVEYPPVEPGEAPEGHSRIDVSFNSKADPGLVDVGTSSPGSDRASPWPYPAPGNWPSYRETESASLDPQTKQGRPVGEGEVLDFRDPAELLDQMGTRAPAPPEADAALLTPVNEDLGGRNTQSYPEAGPVPSEPDVPVPPLEGEVLPHYPESGHVPPLRGGKYVIGLEDHVGSNDQVFTYNGANLETCEHSHGRCSQHAFCTDYTTGFCCHCQSRFYGNGKHCLPEGAPHRVNGKVSGRLRVGHIPVHFTDVDLHAYIVGNDGRAYTAISHVPQPAAQALLPVLPIGGLFGWLFALEKPGSENGFSLTGATFVHDVEVTFHPGEERVRITQTAEGLDPENYLSIKTNIEGQVPFIPANFTAHITPYKEFYHYRDSVVTSSSSRSFSLTSGSINQTWSYHIDQNITYQACRHAPRHLAIPATQQLTVDRAFALYSEDEGVLRFAVTNQIGPVEVDSAPVGVNPCYDGSHTCDTTARCHPGTGVDYTCECTPGFQGDGRSCVDVNECATGFHRCGPNSVCVNLVGSYRCECRSGYEFADDQHTCILIAPPPNPCLDGSHTCAPEGQARCIHHGGSSFSCACLPGFIGTGHQCSDVDECAENRCHEAAICYNTPGSFSCRCQPGYRGDGFHCTSDTVPEDSISGLKPCEYQQRYAQTQHAYPGSRIHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVPGTQTPPGSTPPHCGPPPEPTQRPRTVCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGRELQGTRSQPGTRPACIPTVAPPVVRPTPRPDVTPPSVGTFLLYAQGQQIGHLPLNGSRLQKDAARTLLSLHGSIVVGIDYDCRERMVYWTDVAGRTISRASLEAGAEPETIITSGLISPEGLAIDHFRRTMYWTDSGLDKIERAELDGSERKVLFHTDLVNPRAITVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINKDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNHLNYPFSIVSYADHFYHTDWRRDGVISVNKDSGQFTDEFLPEQRSHLYGITAVYPYCPTGRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	GTNGIISTQDFPRET ECCCEEECCCCCCCC	23.04	26239621
129	Phosphorylation	ILYREDTSGAVLSLA EEEECCCCHHHHHHH	36.76	29109428
345	Phosphorylation	GHSRIDVSFNSKADP CCCCEEEEECCCCCC	18.24	27180971
348	Phosphorylation	RIDVSFNSKADPGLV CEEEEECCCCCCCCE	27.49	27180971
361	Phosphorylation	LVDVGTSSPGSDRAS CEEECCCCCCCCCCC	32.87	25338131
384	Phosphorylation	NWPSYRETESASLDP CCCCCCCCCCCCCCC	26.66	27180971
386	Phosphorylation	PSYRETESASLDPQT CCCCCCCCCCCCCCC	30.49	26824392
681	N-linked_Glycosylation	QVPFIPANFTAHITP CCCCCCCCEEEEECC	29.46	19349973
716	N-linked_Glycosylation	SLTSGSINQTWSYHI EEECCCCCEEEEEEE	34.62	-
726	N-linked_Glycosylation	WSYHIDQNITYQACR EEEEECCCEEHHHHC	25.48	-
1058	Phosphorylation	RESLLEHYGGTPRDD HHHHHHHCCCCCCCC	14.10	24719451
1061	Phosphorylation	LLEHYGGTPRDDQYV HHHHCCCCCCCCCCC	15.70	24719451
1152	N-linked_Glycosylation	QIGHLPLNGSRLQKD EEECCCCCCHHHHHH	44.44	-
1248	Methylation	AELDGSERKVLFHTD EECCCCCCEEEEECC	35.76	16289347
1272	Phosphorylation	DPIRGNLYWTDWNRE ECCCCCEEEECCCCC	15.40	29899451
1274	Phosphorylation	IRGNLYWTDWNREAP CCCCEEEECCCCCCC	19.99	25521595
1336	Methylation	TLPDGTGRRVIQNHL ECCCCCCCHHHHHCC	29.54	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NID2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NID2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NID2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NID2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NID2_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-681, AND MASSSPECTROMETRY.	19349973 [Abstract]