PLD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLD3_MOUSE
• UniProt AC: O35405
• Protein Name: Phospholipase D3
• Gene Name: Pld3
• Organism: Mus musculus (Mouse).
• Sequence Length: 488
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
• Protein Description: May be involved in APP processing..
• Protein Sequence: MKPKLMYQELKVPVEEPAGELPLNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLEFPNATTSNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLQQLQALAPRGVKVRIAVSKPNGPLADLQSLLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRSFDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDSARSFIYIAVMNYLPTMEFSHPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSDPSMRSFLLSLAALHDNHTHSDIQVKLFVVPTDESQARIPYARVNHNKYMVTERASYIGTSNWSGSYFTETAGTSLLVTQNGHGGLRSQLEAVFLRDWESPYSHDLDTSANSVGNACRLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MKPKLMYQELKVPV -CCCCCCEEEEECCC	14.85	22499769
11	Ubiquitination	KLMYQELKVPVEEPA CCCEEEEECCCCCCC	43.68	22790023
30	Ubiquitination	LNEIEAWKAAEKKAR HHHHHHHHHHHHHHH	44.78	22790023
132	N-linked_Glycosylation	FYWTLTNNDTHTQEP HEEECCCCCCCCCCC	50.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.